Welcome to the website of Professor Steven V. Ley FRS CBE and his organic chemistry research group. Our labs (The Whiffen and the Innovative Technology Centre) are in the Department of Chemistry at the University of Cambridge.
- Mild and selective heterogeneous catalytic hydration of nitriles to amides by flowing through manganese dioxide
- Metal-free coupling of saturated heterocyclic sulfonylhydrazones with boronic acids
- Investigation of a lithium-halogen exchange flow process for the preparation of boronates by using a cryo-flow reactor
- Design, synthesis, and biological evaluation of an allosteric inhibitor of HSET that targets cancer cells with supernumerary centrosomes
- Sustainable flow Oppenauer oxidation of secondary benzylic alcohols with a heterogeneous zirconia catalyst
- Continuous flow-processing of organometallic reagents using an advanced peristaltic pumping system and the telecoped flow synthesis of (E/Z)-tamoxifen
- Conducting Appel reactions in flow using a triphenylphosphine monolith Steve gives a one-on-one tutorial about flow chemistry and demonstrates how these systems can be applied to a given reaction in practice.
- Flow chemistry: introducing the Innovative Technology Centre Steve shows you around the ITC and explains what can be achieved using automated flow methods.
From the archives
Our first Whiffen Lab Letter 1 from March 1987 when Steve was at Imperial College.
“Complex synthesis remains a challenging occupation requiring an exceptional level of experimental skill, extensive knowledge of both mechanistic and molecular reactivity, and a bold, inventive, and creative spirit. It is the combination of these qualities that transforms the synthesis process from one of simple logistics to an art form.”