2010-Present Publications

848. Utilization of flow chemistry in catalysis: new avenues for the selective synthesis of bis(indolyl)methanes S.S. Mohapatra, Z.E. Wilson, S. Roy, S.V. Ley, Tetrahedron, 2017, 73, 1812-1819

847. One-pot acid-Catalyzed ring-opening/cyclization/oxidation of aziridines with N-tosylhydrazones: access to 1,2,4-triazines L. Crespin, L. Biancalana, T. Morack, D.C. Blakemore, S.V. Ley Org. Lett., 2017, 19, 1084-1087

846. Rapid asymmetric synthesis of disubstituted allenes by coupling of flow-generated diazo compounds and propargylated amines J-S. Poh, S. Makai, T. v.Keutz, D.N. Tran, C. Battilocchio, P. Pasau, S.V. Ley Angew. Chem. Int. Ed. 2017, 56, 1864-1868846. Image

845. Continuous flow hydration of pyrazine-2-carbonitrile in a manganese dioxide column reactor C. Battilocchio, S-H. Lau, J.M. Hawkins, S.V. Ley Org. Synth2017, 94, 34-45845. Image

844. On the synthesis and reactivity of 2,3-dihydropyrrolo[1,2-a]quinazolin-5(1H)-ones C.L. Sutherell and S.V. Ley Synthesis, 2017, 49, 135-144844-image

843. Engineering chemistry: integrating batch and flow reactions on a single, automated reactor platform D.E. Fitzpatrick and S.V. Ley, React. Chem. Eng. 2016, 1, 629-635843-image

842. Visible light activation of boronic esters enables efficient photoredox C(sp2)-C(sp3) cross-couplings in flow F. Lima, M.A. Kabeshov, D.N. Tran, C. Battilocchio, J. Sedelmeier, G. Sedelmeier, B. Schenkel, S.V. Ley, Angew. Chem. Int. Ed. 2016, 55, 14085-14089


841. The total synthesis of the bioactive natural product Plantazolicin A and its biosynthetic precursor Plantazolicin B S. Fenner, Z.E. Wilson, S.V. Ley, Chem. Eur. J. 2016, 22, 15902-15912


840. A multicomponent approach for the preparation of homoallylic alcohols J-S. Poh, S-H. Lau, I.G. Dykes, D.N. Tran, C. Battilocchio, S.V. Ley, Chem. Sci. 2016, 7, 6803-6807840-image

839. Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia S. Picaud, K. Leonards, J-P. Lambart, O. Dovey, C. Wells, O. Federov, O. Monteiro, T. Fujisawa, C-Y. Wang, H. Lingard, C. Tallant, N. Nikbin, L. Guetzoyan, R.J. Ingham, S.V. Ley, P. Brennan, S. Müller, A. Samsonova, A-C. Gingras, J. Schwaller, G. Vassiliou, S. Knapp, P. Fiippakopoulos, Science Adv. 2016, 2, e1600760slide1

838. Flow Chemistry in Europe V. Hessel and S.V. Ley, J. Flow. Chem., 2016, 6, 135

837. Combination of enabling technologies to improve and describe the stereoselectivity of Wolff–Staudinger cascade reaction B. Musio, F. Mariani, E.P. Sliwinski, M.A. Kabeshov, H. Odajima, S.V. Ley, Synthesis, 2016, 48, 3515-3526

836. Continuous processing and efficient in situ reaction monitoring of hypervalent iodine(III) mediated cyclopropanation using benchtop NMR spectroscopy B. Ahmed-Omer, E. Sliwinski, J.P. Cerroti, S.V Ley, Org. Process Res. Dev2016, 20, 1603-1614


835. Taming hazardous chemistry by continuous flow technology M. Movsisyan, E.I.P. Delbeke, J.K.E.T. Berton, C. Battilocchio, S.V. Ley, C.V. Stevens, Chem. Soc. Rev. 2016, 45, 4892-4928

Over the last two decades, flow technologies have become increasingly popular in the field of organic chemistry, offering solutions for engineering and/or chemical problems. Flow reactors enhance the mass and heat transfer, resulting in rapid reaction mixing, and enable a precise control over the reaction parameters, increasing the overall process selectivity, efficiency and safety. These features allow chemists to tackle unexploited challenges in their work, with the ultimate objective making chemistry more accessible for laboratory and industrial applications, avoiding the need to store and handle toxic, reactive and explosive reagents. This review covers some of the latest and most relevant developments in the field of continuous flow chemistry with the focus on hazardous reactions.

834. Editorial – flow chemistry and catalysis S.V. Ley, Catal. Sci. Technol. 2016, 6, 4676-4677

834. Image

833. Synthesis of trifluoromethylated isoxazoles and their elaboration through inter- and intra-molecular C-H arylation J-S. Poh, C. García-Ruiz, A. Zúñiga, F. Meroni, D.C. Blakemore, D.L. Browne, S.V. Ley, Org. Biomol. Chem. 2016, 14, 5983-5991

833. Image copy

833. Image832. Controlled generation and use of CO in flow S.V.F. Hansen, Z.E. Wilson, T. Ulven, S.V. Ley React. Chem. Eng. 2016, 1, 280-287


831. Identification and development of 2,3-dihydropyrrolo[1,2-a]quinazolin-5(1H)-one inhibitors targeting bromodomains within the switch/sucrose nonfermenting complex C.L. Sutherell, C. Tallant, O.P Monteiro, C. Yapp, J.E. Fuchs, O. Fedorov, P. Siejka, S. Müller, S. Knapp, J.D. Brenton, P.E. Brennan, S.V. Ley J. Med. Chem. 2016, 59, 5095-5101


830. Solvent-free continuous operations using small footprint reactors: a key approach for process intensification T. Ouchi, R.J. Mutton, V. Rojas, D.E. Fitzpatrick, D.G. Cork, C. Battilocchio, S.V. Ley ACS Sustainable Chem. Eng. 2016, 4, 1912-1916830. Image

829. Enabling technologies for the future of chemical synthesis D.E. Fitzpatrick, C. Battilocchio, S.V. Ley ACS Central Science 2016, 2, 131-138829. Image

828. Iterative reactions of transient boronic acids enable sequential C-C bond formation C. Battilocchio, F. Feist, A. Hafner, M. Simon, D.N. Tran, D.M. Allwood, D.C. Blakemore, S.V. Ley Nature Chem. 2016, 8, 360-367

828. Image

827. Synthesis of natural and unnatural cyclooligomeric depsipeptides enabled by flow chemistry D. Lücke, T. Dalton, S.V. Ley, Z.E. Wilson Chem. Eur. J. 2016, 22, 4206-4217

827 Image

826. (S)-5-Pyrrolidin-2-yltetrazole and (R)-5-Pyrrolidin-2-yltetrazole Second Update R.J. Mutton, S.V. Ley,   Electronic Encyclopaedia of Reagents in Organic Synthesis. Ed. L.A. Paquette 2016

825. A novel internet-based reaction monitoring, Control and autonomous self-optimization platform for chemical synthesis D.E. Fitzpatrick, C. Battilocchio, S.V. Ley Org. Process. Res. Dev 2016, 20, 386-394

825 OPRD Paper

824. A multistep continuous flow synthesis machine for the preparation of pyrazoles via a metal-free amine-redox process J-S. Poh, D.L. Browne, S.V. Ley React. Chem. Eng. 2016, 1, 101-105

824 image

823. An orthogonal biocatalytic approach for the safe generation and use of HCN in a multistep continuous preparation of chiral O-acetylcyanohydrins A. Brahma, B. Musio, U. Ismayilova, N. Nikbin, S.B. Kamptmann, P. Siegert, G.E. Jeromin, S.V. Ley, M. Pohl Synlett 2016, 27, 262-266graphical abstract3

822. Dynamic flow synthesis of porous organic cages M.E. Briggs, A.G. Slater, N. Lunt, S. Jiang, M.A. Little, R.L. Greenaway, T. Hasell, C. Battilocchio, S.V. Ley, A.I. Cooper Chem. Commun. 2015, 51, 17390-17393GA

821. Synthesis of a precursor to sacubitril using enabling technologies S-H. Lau, S.L. Bourne, B. Martin, B. Schenkel, G. Penn, S.V. Ley Org. Lett. 2015, 17, 5436-5439IMAGE ol-2015-02806k_0008

820. The ‘Internet of Chemical Things S.V. Ley, D.E. Fitzpatrick, R.J. Ingham, N. Nikbin Beilstein Magazine 2015, 1, 11-12

819.  Callipeltosides A, B and C: total syntheses and structural confirmation J.R. Frost, C.M. Pearson, T.M. Snaddon, R.A. Booth, R.M. Turner, J. Gold, D.M. Shaw, M.J. Gaunt, S.V. Ley Chem. Eur. J. 2015, 21, 13261-13277

Darts illustration proof

818. Machine-assisted organic synthesis S.V. Ley, D.E. Fitzpatrick, R.M. Myers, C. Battilocchio, R.J. Ingham Angew. Chem. Int. Ed. 2015, 54, 10122-10136mom

817. Design, synthesis and evaluation of semi-synthetic triazole-containing caffein acid analogues as 5-lipooxygenase inhibitors De Lucia, O Méndez Lucio, B. Musio, A. Bender, M. Listing, S. Dennhardt, A. Koeberle, U. Garscha, R. Rizzo, S. Manfredini, O. Werz, S.V. Ley Eur. J. Med. Chem. 2015, 101, 573-583Microsoft Word - EJMECH Corrigenda_V1

Corrigendum to Design, synthesis and evaluation of semi-synthetic triazole-containing caffein acid analogues as 5-lipooxygenase inhibitors 

816. A practical deca-gram scale ring expansion of (R)-(−)-carvone to (R)-(+)-3-methyl-6-isopropenyl-cyclohept-3-enone-1 L. de c. Alves, A.L. Desiderá, K.T. de Oliveira, S. Newton, S.V. Ley, T.J Brocksom Org. Biomol. Chem. 2015, 13, 7633-7642


815. Continuous flow metathesis for direct valorization of food waste: an example of cocoa butter triglyceride C. Schotten, D. Plaza, S. Manzini, S.P. Nolan, S.V. Ley, D.L. Browne, A. Lapkin ACS Sustainable Chem. Eng. 20153, 1453-1459

IMAGE copy

814. Machines vs malaria: a flow-based preparation of the drug candidate OZ439 S-H Lau, A. Galván, R.R. Merchant, C. Battilocchio, J.A. Souto, M.B. Berry, S.V. Ley Org. Lett. 2015, 17, 3218-3221


813. Modeling mesoscale reactors for the production of fine chemicals P.W. Witt, S. Somasi, I. Khan, D.W. Blaylock, J.A. Newby, S.V. Ley Chem. Eng. J2015, 278, 353-362

812. A versatile room-temperature route to di- and trisubstituted allenes using flow-generated diazo compounds J.S. Poh, D.N. Tran, C. Battilocchio, J.M Hawkins, S.V. Ley Angew. Chem. Int. Ed. 2015, 54, 7920-7923


811. Generation of reactive ketenes under flow conditions through zinc-mediated dehalogenation A. Hafner, S.V. Ley Synlett, 2015, 26, 1470-1474

i_b0113_s1_10-1055_s-0034-1380679810. Facilitating biomimetic syntheses of borrerine derived alkaloids by means of flow-chemical methods S.B. Kamptmann, S.V. Ley Aust. J. Chem2015, 68, 693-696CH14530_TOC

809. Development of a web-based platform for studying lithiation reactions in silico M.A. Kabeshov, E. Sliwinski, D.E. Fitzpatrick, B. Musio, J.A. Newby, W.D.W. Blaylock, S.V. Ley Chem. Commun2015, 51, 7172-7175


808. Development of a flow method for the hydroboration/oxidation of olefins J.A. Souto, R.A. Stockman, S.V.Ley Org. Biomol. Chem. 2015, 13, 3871-3877808 diagram

807.  Design, synthesis and evaluation of tetra substituted pyridines as potent 5-HT2C receptor agonists G. Rouquet, D.E. Moore, M. Spain, D.M. Allwood, C. Battilocchio, D.C. Blakemore, P.V. Fish, S. Jenkinson, A.S. Jessiman, S.V. Ley, G. McMurray, R.A.Storer, ACS Med. Chem. Lett.  2015, 6, 329-333

807 reaction diagram

806. Chemistry in a changing world S.V. Ley, R.M. Myers, D.E. Fitzpatrick L’Actualite Chimique, Fevrier-Mars 2015, 393-394, 96-101

Chemistry in a changing world

805. Organic synthesis: march of the machines S.V. Ley, D.E.Fitzpatrick, R.J. Ingham, R.M. Myers Angew. Chem. Int. Ed. 2015, 54, 3449-3464TOC-Graphic

804. Flow cyclopropanation using in-situ generated diazo compounds N.M. Roda-Monsalvez, D.N. Tran, C. Battilocchio, R. Labes, R.J. Ingham, J.M.Hawkins, S.V. Ley Org. Biomol. Chem. 2015, 13, 2550-2554

803. Flow chemistry: intelligent processing of gas-liquid transformations using a tube-in-tube reactor M. Brzozowski, M. O’Brien, S.V. Ley,  A. Polyzos Acc. Chem. Res. 2015, 48, 349-362

ar-2014-00359m_0034802.  Back pressure regulation of slurry-forming reactions in continuous flow B.J. Deadman, D.L. Browne, I.R. Baxendale, S.V. Ley Chem. Eng. Technol2015, 38, 259-264


801. Flow chemistry as a discovery tool to access sp2–sp3 cross-coupling reactions via diazo compounds D.N. Tran, C. Battilocchio,  S. Lou, J. M. Hawkins, S.V. Ley Chem. Sci. 2015, 6, 1120-1125


800. Total syntheses of linear polythiazole/oxazole plantazolicin A and its biosynthetic precursor plantazolicin B Z.E. Wilson, S. Fenner, S.V. Ley Angew. Chem. Int. Edn. 2015, 54, 1284-1288

Table of Contents edited

799. A systems approach towards an intelligent and self-controlling platform for integrated continuous reaction sequences R.J. Ingham,  C. Battilocchio, D.E. Fitzpatrick, E. Sliwinski, J.M. Hawkins, S.V. Ley Angew. Chem. Int. Edn2015, 54, 144-148

Pyriamid Jigsaw

798. The rapid synthesis of oxazolines and their heterogeneous oxidation to oxazoles under flow conditions S. Glockner, D.N. Tran, R.J. Ingham, S. Fenner, Z.E. Wilson, C. Battilocchio, S.V. Ley Org. Biomol. Chem. 2015, 13, 207


797. Process intensification for the continuous flow hydrogenation of ethyl nicotinate T. Ouchi, C. Battilocchio, J.M. Hawkins, S.V. Ley Org. Process Res. Dev., 2014, 18, 1560-1566

op500208j copy

796. Reconfiguration of a continuous flow platform for extended operation: application to a cryogenic fluorine-directed ortho-lithiation reaction J.A. Newby, D.W. Blaylock, P.M. Witt, R.M. Turner, P.L. Heider, B.H. Harji, D.L. Browne, S.V. Ley Org. Process Res. Dev.2014, 18, 1221-1228


795. Design and application of a low-temperature continuous flow chemistry platform J.A. Newby, D.W. Blaylock, P.M. Witt, J.C. Pastre, M.K. Zacharova, S.V. Ley, D. L. Browne, Org. Process Res. Dev. 2014, 18, 1211-1220


794. A general continuous flow method for palladium catalysed carbonylation reactions using single and multiple tube-in-tube gas-liquid microreactors U.Gross, P.Koos, M.O’Brien, A.Polyzos, S.V.Ley, Chem. Eur. J. 2014, 6418-6430

tfigure6793. Regioselective preparation of saturated spirocyclic ring-expanded fused pyrazoles R.R. Merchant, D.M.Allwood, D.C.Blakemore, S.V.Ley, J. Org. Chem. 2014, 880-8811


792. Flow chemistry meets advanced functional materials R.M. Myers, D.E. Fitzpatrick, R.M. Turner, S.V. Ley Chem. Eur. J.  2014, 20, 12348-12366

792. Chem. Eur. J., 2014, 20, 12348-12366

791. Expedient preparation of nazlinine and a small library of indole alkaloids using flow electrochemistry as an enabling technology M.A. Kabeshov, B. Musio, P.R.D. Murray, D.L. Browne, S.V. Ley Org. Lett.  2014, 16, 4618-4621


790. Highly regioselective lithiation of pyridines bearing an oxetane unit by n-butyllithium G. Rouquet, D.C. Blakemore, S.V. Ley Chem. Comm. 2014, 50, 8908-8911GA

789. Synthesis of riboflavines, quinoxalinones and benzodiazepines through chemoselective flow based hydrogenations, M. Baumann, I.R. Baxendale, C.H. Hornung, S.V. Ley, M.V. Rojo, K.A. Roper Molecules 2014, 19, 9736-9759molecules-19-09736-ag

788. Preparation of unsymmetrical ketones from tosylhydrazones and aromatic aldehydes via formyl C-H bond insertion, D.M. Allwood, D.C. Blakemore, S.V. Ley Org. Lett. 2014, 16, 3064-3067normal.img-000

787. Synthesis and use of trifluoromethylated azomethine ylide precursor: ethyl 1-benzyl-trans-5-(trifluoromethyl) pyrrolidine-3-carboxylate D.M. Allwood, D.L. Browne, S.V. Ley, Org. Synth. 2014, 91, 162-174

Org Synth Scheme

786. Continuous flow chemistry: a discovery tool for new chemical reactivity patterns J. Hartwig, J.B. Metternich, N. Nikbin, A. Kirschning, S.V. Ley, Org. Bio. Chem2014, 12, 3611GA-1

785. Accelerating spirocyclic polyketide synthesis using flow chemistry S. Newton,  C.F. Carter, C.M. Pearson, L.C. Alves, H. Lange, P. Thansandote, S.V. Ley,  Angew. Chem. Int. Edn. 2014, 53, 4915-4920mcontent

784. Flow based cerium oxide-enhanced low-level palladium Sonogashira and Heck coupling reactions by perovskite type oxide catalysts C. Battilocchio, B.N. Bhawal, R. Chorghade, B.J. Deadman, J.M. Hawkins, S.V. Ley, Israel Journal of Chem2014, 54, 371-380Perovskite_pic 

783. Machine-assisted synthesis of modulators of the histone reader BRD9 using flow methods of chemistry and frontal affinity chromatography L. Guetzoyan, R. Ingham, N. Nikbin, J. Rossignol, M. Wolling, M. Baumert, N.A. Burgess-Brown, C.M. Strain-Damerell, L. Shrestha, P. Brennan, O. Fedorov, S. Knapp, S.V Ley, Med. Chem. Commun. 20145, 540-546


782. Fully automated sequence-specific synthesis of alpha-peptides using flow chemistry K. Rahbek-Knudsen, M. Ladlow, Z. Bandpey, S.V. Ley, J. Flow. Chem. 2014, 4, 18-21GA3

781. Integration of enabling methods for the automated flow preparation of piperazine-2-carboxamide R.J. Ingham, C. Battilocchio, J. M. Hawkins and S.V. Ley, Beilstein J. Org. Chem2014, 10, 641-652


780. Mild and selective heterogeneous catalytic hydration of nitriles to amides by flowing through manganese dioxide C. Battilocchio, J.M. Hawkins, S.V. Ley, Org. Lett. 2014, 16, 1060-1063


779. Metal-free coupling of saturated heterocyclic sulfonylhydrazones with boronic acids D.M. Allwood, D.C. Blakemore, A.D. Brown, S.V. Ley, J. Org. Chem2014, 79, 328-338jo-2013-02526z_0011

778. Investigation of a lithium-halogen exchange flow process for the preparation of boronates by using a cryo-flow reactor J.A. Newby, L. Huck, D.W. Blaylock, P.M. Witt, S.V. Ley, D.L. Browne, Chem. Eur. J., 2014, 20, 263-271


777. Fragment-based hit identification thinking in 3D A.D. Morley, A. Pugliese, K. Birchall, J. Bower, P. Brennan, N. Brown, T. Chapman, M. Drysdale, I.H. Gilbert, S. Hoelder, A. Jordan, S.V. Ley, A. Merritt, D. Miller, M.E. Swarbrick, P.G. Wyatt, Drug Discovery Today, 2013, 18, 1221-1227

776. Design, synthesis, and biological evaluation of an allosteric inhibitor of HSET that targets cancer cells with supernumerary centrosomes C.A. Watts, F.R. Richards, A. Bender, P.J. Bond, O. Korb, O. Kern, M. Riddick, P. Owen, R.M. Myers, J. Raff, F. Gergely, D.I. Jodrell, S.V. Ley, Chem. Biol. 201320, 1399–1410


775. Sustainable flow Oppenauer oxidation of secondary benzylic alcohols with a heterogeneous zirconia catalyst R. Chorghade, C. Battilocchio, J.M. Hawkins, S.V. Ley, Org. Lett2013, 15, 5698-5701ol-2013-027107_0009

774. Flow chemistry syntheses of natural products J.C. Pastre, D.L. Browne, S.V. Ley, Chem. Soc. Rev. 2013, 42, 8801-9198


773. Continuous flow-processing of organometallic reagents using an advanced peristaltic pumping system and the telescoped flow synthesis of (E/Z)-tamoxifen P.R.D. Murray, D.L. Browne, J.C. Pastre, C. Butters, D. Guthrie, S.V. Ley, Org. Proc. Res. Dev2013, 17, 1192-1208


772. Scaling-up of continuous flow processes with gases using a tube-in-tube reactor: in-line titrations and fanetizole synthesis with ammonia J. Pastre, D.L. Browne, M. O’Brien, S.V. Ley, Org. Proc. Res. Dev2013, 17, 1183-1191


771. The application of a monolithic triphenylphosphine reagent for conducting gem-dibromoolefination reactions in flow K.A. Roper, M.B. Berry, S.V. Ley, Beilstein J. Org. Chem. 2013, 9, 1781-1790


770. Flow synthesis and biological studies of an analgesic adamantane derivative that inhibits P2X7-evoked glutamate release C. Battilocchio, L. Guetzoyan, C. Cervetto, L. Di Cesare Mannelli, D. Frattaroli, I. R. Baxendale, G. Maura, A. Rossi, L. Sautebin, M. Biava, C. Ghelardini, M. Marcoli, S.V. Ley, A.C.S. Med. Chem. Lett. 2013, 4, 704-709


769. A continuous flow solution to achieving efficient, aerobic anti-Markovnikov Wacker oxidation S.L. Bourne, S.V. Ley, Adv. Synth. Catal. 2013, 355, 1905-1910


768. A prototype device for evaporation in batch and flow chemical processing B.J. Deadman, C. Battilocchio, E. Sliwinski, S.V. Ley, Green Chem., 2013, 15, 2050-2055768

767. The synthesis of neurotensin antagonist SR 48692 for prostate cancer research I.R. Baxendale, S. Cheung, M.O. Kitching, S.V. Ley, J.W. Shearman Bio. Org. Med. Chem. 2013, 21, 4378-4387

766. Studies of a diastereoselective electrophilic fluorination reaction employing a cryo-flow reactor K. Nakayama, D.L. Browne, I.R. Baxendale, S.V. Ley, Synlett 2013, 24, 1298-1302


765. A machine-assisted flow synthesis of SR48692: a probe for the investigation of neurotensin receptor-1 C. Battilocchio, B.J. Deadman, N. Nikbin, M.O. Kitching, I.R. Baxendale, S.V. Ley, Chem. Eur. J. 2013, 19, 7917-7930.

A MachineAssisted Flow Synthesis of SR48692: A Probe for the Inv

764. Camera enabled techniques for organic synthesis S.V. Ley, R.J. Ingham, M. O’Brien, D.L. Browne, Beilstein J. Org. Chem. 2013, 9, 1051-1072.


763. Continuous cold without cryogenic consumables: development of a convenient laboratory tool for low temperature flow processes D.L. Browne, B.H. Harji, S.V. Ley, Chem. Eng. and Technol. 2013, 36, 959-967.

762. A mild and efficient flow procedure for the transfer hydrogenation of ketones and aldehydes using hydrous zirconia C. Battilocchio, J.M. Hawkins, S.V. Ley, Org. Lett2013, 15, 2278-2281.


761. Synthesis of spongistatin 2 employing a new route to the EF fragment H. Kraus, A. Français, M. O’Brien, J.R. Frost, A. Diéguez-Vázquez, A. Polara, N. Baricordi, R. Horan, D-S. Hsu, T. Tsunoda, S.V. Ley, Chem. Sci. 2013, 4, 1989-1994.


760. An expedtious synthesis of imatinib and analogues utilising flow chemistry methods M.D. Hopkin, I.R. Baxendale and S.V. Ley, Org. Biomol. Chem2013, 11, 1822-1839.

GA 759. The synthesis of Bcr-Abl inhibiting anticancer pharmaceutical agents imatinib, nilotinib and dasatinib B. Deadman, M.D. Hopkin, I.R. Baxendale, S.V. Ley, Org. Biomol. Chem. 2013, 11, 1766-1800.GA-1

758. Synthesis of (-)-hennoxazole A: integrating batch and flow chemistry methods A. Fernández, Z.G. Levine, M. Baumann, S. Sulzer-Mossé, C. Sparr, S. Schläger, A. Metzger, I.R. Baxendale, S.V. Ley, Synlett, 2013, 24, 514-518. Untitled-1

757.  Flow microwave technology and microreactors in synthesis I.R. Baxendale, C. Hornung, S.V. Ley, J. de M. Muñoz Molina, A. Wikström, Aust. J. Chem., 2013, 66, 131-144.

756.  Flow chemistry synthesis of zolpidem, alpidem and other GABAA agonists and their biological evaluation through the use of in-line frontal affinity chromatography L. Guetzoyan, N. Nikbin, I.R. Baxendale, S.V. Ley, Chem. Sci., 2013, 4, 764-769.

755. Flow chemistry syntheses of styrenes, unsymmetrical stilbenes and branched aldehydes S.L. Bourne, M. O’Brien, S. Kasinathan, P. Koos, P. Tolstoy, D.X. Hu, R.W. Bates, B. Martin, B. Schenkel, S.V. Ley, ChemCatChem., 2013, 5, 159-172.


754. Synthesis and use of a new trifluoromethylated azomethine ylide precursor G. Tran, R. Meier, L. Harris, D.L. Browne, S.V. Ley, J. Org. Chem., 2012, 77, 11071-11078.

753. Synthesis of enantiomerically enriched 3-amino-2-oxindoles through a palladium-mediated asymmetric intramolecular arylation of α-ketimino amides P. Tolstoy, S.X.Y. Lee, C. Sparr, S.V. Ley, Org. Lett. 201214, 4810-4813.

752. The evolution of immobilised reagents and their application in flow chemistry for the synthesis of natural products and pharmaceutical compounds by R.M. Myers, K.A. Roper, I.R. Baxendale and S.V. Ley. In “Modern Tools for the Synthesis of Complex Bioactive Molecules”, Ed. J. Cossy, S. Arseniyadis, J. Wiley, N.Y., ISBN 978-0-470-61618-5, 2012, Chapter 11, p. 359-394.

751. Total synthesis of callipeltosides A, B and C J.R. Frost, C.M. Pearson, T.N. Snaddon, R.A. Booth, S.V. Ley, Angew. Chem. Int. Ed. 2012, 51, 9366-9371.

750. Continuous multiple liquid–liquid separation: diazotization of amino acids in flow D.X. Hu , M. O’Brien, S.V. Ley, Org. Lett201214, 4246-4249. 749. On being green: can flow chemistry help? S.V. Ley, Chem. Rec2012, 12, 378-390.

748. A prototype continuous-flow liquid–liquid extraction system using open-source technology M. O’Brien, P. Koos, D.L. Browne, S.V. Ley, Org. Biomol. Chem. 201210, 7031-7036. 747.  A “catch-react-release” method for flow synthesis of 2-aminopyrinidines and preparation of the imatinib base R.J. Ingham, E. Riva, N. Nikbin, I.R. Baxendale, S.V. Ley, Org. Lett. 2012, 14, 3920–3923.

746. Continuous flow reaction monitoring using an on-line miniature mass spectrometer D.L. Browne, S. Wright, B.J. Deadman, S. Dunnage, I.R. Baxendale, R.M. Turner, S.V. Ley, Rapid Commun. Mass Spectrom. 2012, 26, 1999-2010.

745. Flow synthesis using gaseous ammonia in a Teflon AF 2400 tube in tube reactor: Paal-Knorr formation and gas concentration measurement with in-line titration P.B. Cranwell, M. O’Brien, D. Browne, P. Koos, A. Polyzos, M. Pêna López, S.V. Ley, Org. Biomol. Chem2012, 10, 5774-5779.

744. A total synthesis of the ammonium ionophore (–)-enniatin B D.X. Hu, M. Bielitza, P. Koos, S.V. Ley, Tetrahedron Lett. 2012, 53, 4077-4079.

743. Asymmetric homogenous hydrogenation in flow using tube-in-tube reactor S. Newton, S.V. Ley, E.C. Arce, D. Grainger, Adv. Synth. Catal2012, 354, 1805-1812. 742. Rotamers or diastereomers?  An overlooked NMR solution D.X. Hu, P. Grice, S.V. Ley, J. Org. Chem2012, 77, 5198-5202.

741. The continuous flow processing of gaseous ammonia using a Teflon AF-2400 tube in tube reactor: the synthesis of thioureas and in-line titrations D.L. Browne, M. O’Brien, P. Koos, P.B. Cranwell, A. Polyzos, S.V. Ley, Synlett 2012, 1402-1406.

740. Continuous preparation of arylmagnesium reagents in flow with in-line IR monitoring T. Brodmann, P. Koos, A. Metzger, P. Knochel, S.V. Ley, Org. Proc. Res. Dev. 2012, 16, 1102-1113.

739. A flow based synthesis of 2-aminoadamantane-2-carboyxlic acid C. Battilocchio, I.R. Baxendale, M. Biava, M.O. Kitching and S.V. Ley, Org. Proc. Res. Dev. 2012, 16, 798-810.

738. A-ring dihalogenation increases the cellular activity of combretastatin-templated tetrazoles T.M. Beale, D.M. Allwood, A. Bender, P.J. Bond, J.D. Brenton, D.S. Charnock-Jones, S.V. Ley, R.M. Myers*, J.W. Shearman, J. Temple, J. Unger, C.A. Watts, J. Xian, ACS Med. Chem. Lett. 2012, 3, 177-181.

737. Increased endothelial cell selectivity of triazole-bridged dihalogenated A-ring analogues of combretastatin A1 T.M. Beale, P.J. Bond, J.D. Brenton, D.S.Charnock-Jones, S.V. Ley, R.M. Myers*, Bioorg. Med. Chem. 2012, 20, 1749-1759.

736. The oxygen mediated continuous flow synthesis of 1,3-butadiynes using Teflon AF-2400 to effect gas-liquid contact T.P. Peterson, A. Polyzos, M. O’Brien, T. Ulven, I.R. Baxendale, S.V. Ley, Chem. Sus. Chem. 2012, 5, 274-277.

735. A total synthesis of millingtonine A J. Wegner, S.V. Ley, A. Kirschning, A-L. Hansen, J. Montenegro Garcia, I.R. Baxendale, Org. Lett. 2012, 14, 696-699.

734. Scale-up of flow assisted synthesis of C2-symmetric chiral PyBox-ligands C. Battilocchio, M. Baumann, I.R. Baxendale, M. Biava, M.O. Kitching, S.V. Ley, R.M. Martin*, S.A. Ohnmacht, N.D.C. Tappin, Synthesis 2012, 44, 635-647.

733. Continuous stream processing: a prototype magnetic field induced flow mixer P. Koos, D.L. Browne, S.V. Ley, Green Process. and Synth. 2012, 1, 11-18.

732. Twenty Five Years of Azadirachtins (1986-2011), H.E. Hummel, D.F. Hein, S.V. Ley, E.D. Morgan, W. Kraus, H. Schmutterer, Pesticides, 2011, 1-4, 49-56.

731. The application of a monolithic triphenylphospine reagent for conducting Appel reactions in flow microreactors K. Roper, H. Lange, A. Polyzos, M.B. Berry, I.R. Baxendale, S.V. Ley, Bielstein J. Org. Chem. 2011, 7, 1648-1655.

730. Piecing together the puzzle: understanding a mild, metal free reduction method for large scale synthesis of hydrazines D.L. Browne,* I.R. Baxendale, S.V. Ley, Tetrahedron 2011, 67, 10296-10303.

729. Syngas mediated C-C bond formation in flow: selective rhodium catalysed hydroformylation of styrenes S. Kasinathan, S.L. Bourne, P. Tolstoy, P. Koos, M. O’Brien, R.W. Bates, I.R. Baxendale, S.V. Ley, Synlett 2011, 2648-2651.

728. The continuous-flow Synthesis of styrenes using ethylene in a palladium catalysed Heck cross-coupling reaction S.L. Bourne, P. Koos, M. O’Brien, B. Martin, B. Schenkel, I.R. Baxendale, S.V. Ley, Synlett 2011, 2643-2647.

727. Teflon AF-2400 mediated gas-liquid contact in continuous flow methoxycarbonylations and in-line FTIR measurement of CO Concentration P. Koos, U. Gross, A. Polyzos, M. O’Brien, I.R. Baxendale, S.V. Ley, Org. Biomol. Chem. 2011, 9, 6903-6908.

726. Piperazic acid-containing natural products: isolation, biological relevance and total synthesis A.J. Oelke, D.J. France, T. Hofmann, G. Wiutschik, S.V. Ley, Nat. Prod. Rep., 2011, 28, 1445-1471.

725. The flow synthesis of heterocycles for natural products and medicinal chemistry applications M. Baumann, I.R. Baxendale, S.V. Ley, Mol. Div. 2011, 15, 613-630.

724. Synthesis of a drug-like focused library of trisubstituted pyrrolidines using integrated flow chemistry and batch methods M. Baumann, R.E. Martin, C. Kuratli, J. Schneider, I.R. Baxendale, S.V. Ley, A.C.S. Comb. Sci. 2011, 13, 405-413.

723. A new enabling technology for convenient laboratory scale continuous flow processing at low temperatures D.L. Browne, M. Baumann, B.H. Harji, I.R. Baxendale, S.V. Ley, Org. Lett. 2011, 13, 3312-3315.

722. The clerodane ring system: investigating the viability of a direct Diels-Alder approach A.T. Merritt, R.H. Pouwer, D.J. Williams, C.M. Williams, S.V. Ley Org. Biomol. Chem. 2011, 9, 4745-4747

721. Hydrogenation in flow: homogenous and heterogeneous catalysts using Teflon AF-2400 to effect gas-liquid contact at elevated pressure M. O’Brien, N. Taylor, A. Polyzos, I.R. Baxendale, S.V. Ley Chem. Sci. 2011, 2, 1250-1257

720. An integrated flow and batch-based approach for the synthesis of O-methyl siphonazole M. Baumann, I.R. Baxendale, M. Brasholz, J.J. Hayward, S.V. Ley, N. Nikbin Synlett 2011, 10, 1375-1380

719. Retinoic acid receptor signalling regulates choroid tissue closure through independent mechanisms in the ventral optic cup and periocular mesenchyme G. Lupo, G. Gestri, M. O’Brien, R.M. Denton, R.A. Chandraratna, S.V. Ley, W.A. Harris, S.W. Wilson, Proc. Natl. Acad. Sci. 2011, 108, 8698-8703

718. Continuous flow processing of slurries: evaluation of an agitated cell reactor D.L. Browne, B.J. Deadman, R. Ashe, I.R. Baxendale, S.V. Ley, Org. Proc. Res. Dev. 2011, 15, 693-697.

717. Allosteric modulation of hormone release from thyroxine and corticosteroid-binding globulins X. Qi, F. Loiseau, W.L. Chan, Y. Yan, Z. Wei, L-G. Milroy, R.M. Myers, S.V. Ley, R.J. Read, R.W. Carrell, A. Zhou,* J. Biol. Chem. 2011, 286, 16163-16173.

716. An overview of the key routes to the best selling 5-membered ring heterocyclic pharmaceuticals M. Baumann, I.R. Baxendale, S.V. Ley, N. Nikbin, Beilstein J. Org. Chem. 2011, 7, 442-495.

715. Less well Known enabling technologies for organic synthesis M. O’Brien, R. Denton, S.V. Ley, Synthesis 2011, 1157-1192.

714. Total synthesis of chloptosin: a dimeric cyclohexapeptide A.J. Oelke, F. Antonietti, L. Bertone, P.B. Cranwell, D.J. France, R.J.M. Goss, T. Hoffman, S. Knauer, S.J. Moss, P.C. Skelton, R.M. Turner, G. Wuitschik, S.V. Ley, Chem. Eur. J. 2011, 17, 4183-4194.

713. Oxidation reactions in segmented and continuous flow chemical processing using a N-(tert Butyl)phenylsulfinimidoyl chloride monolith H. Lange, M.J. Carpenter, A.X. Jones, C.J. Smith, N. Nikbin, I.R. Baxendale, S.V. Ley, Synlett 2011, 6, 869-873.

712.A breakthrough method for the accurate addition of reagents in multi-step segmented flow processing H. Lange, C.F. Carter, M.D. Hopkin, A. Burke, J.G. Goode, I.R. Baxendale, S.V. Ley, Chem. Sci. 2011, 2, 765-769.

711. Diastereoselective chain elongation reactions using microreactors for application in complex molecule assembly C.F. Carter, H. Lange, D. Sakai, I.R. Baxendale, S.V. Ley, Chem. Eur. J., 2011, 17, 3398-3405.

710. A fully automated, multistep flow synthesis of 5-amino-4-cyano-1,2,3-triazoles C.J. Smith, N. Nikbin, S.V. Ley, H. Lange,  I.R. Baxendale, Org. Biomol. Chem., 2011, 9, 1938-1947.

709. Flow synthesis of organic azides and the multistep synthesis of imines and amines using a new monolithic triphenylphosphine reagent C.J. Smith, C.D. Smith, N. Nikbin, S.V. Ley, I.R. Baxendale, Org. Biomol. Chem. 2011, 9, 1927-1937.

708. The continuous flow synthesis of carboxylic acids using CO2 in a tube-in-tube gas permeable membrane reactor A. Polyzos, M. O’Brien, T. Pugaard-Petersen, I.R. Baxendale, S.V. Ley, Angew. Chem. Int. Ed. 2011, 50, 1190-1193. 707. Lab of the future: the importance of remote monitoring and control M.D. Hopkin, I.R. Baxendale, S.V. Ley, Chim. Oggi./Chemistry Today, 2011, 29, 28-32.

706. Safe and reliable synthesis of diazoketones and quinoxalines in a continuous flow reactor L. J. Martin, A.L. Marzinzik, S.V. Ley, I.R. Baxendale, Org. Lett. 2011, 13, 320-323.

705. Total synthesis of iso- and bongkrekic acids: natural antibiotics displaying potent antiapoptotic properties A. Francais, A. Leyva-Pérez, G. Etxebarria-Jardi, J. Peña, S.V. Ley, Chem. Eur. J. 2011, 17, 329-343. 704. Total synthesis of subereomollines A and B J.W. Shearman, R. M. Myers, J.D. Brenton, S.V. Ley, Org. Biomol. Chem. 2011, 9, 62-65. 703. Microwave and flow syntheses of Pseudomonas Quinolone Signal (PQS) and analogues J.T. Hodgkinson, W.R.J.D. Galloway, S. Saraf, I.R. Baxendale, S.V. Ley, M. Ladlow, M. Welch, D.R. Spring, Org. Biomol. Chem. 20119, 57-61.

702. Synthesis of highly substituted 3-nitropyrrolidines and 3-nitropyrroles by a multicomponent multi-step flow sequence M. Baumann, I.R. Baxendale, J. Wegner, A. Kirschning, S.V. Ley, Heterocycles 2010, 82, 1297-1316.

701. Trapping of novel palindromic ligands within native transthyretin prevents amyloid formation S.E. Kolstoe, P.P. Mangione, V. Bellotti, G.W. Taylor, G.A. Tennent, S. Deroe, A.J. Morrison, A.J. Cobb, A. Coyne, M.G. McCammon, R. Gill, M.P. Smith, S.V. Ley, C.V. Robinson, S.P. Wood, M.B. Pepys, Proc. Nat. .Acad. Sci. 2010, 107, 20483-20488.

700. A continuous flow process using a sequence of microreactors with in-line IR analysis of the preparation of N, N-diethyl-4-(3-fluorophenylpiperidin-4-ylidenemethyl) benzamide as a potent and highly selective δ-opioid receptor agonist Z. Qian, I.R. Baxendale, S.V. Ley, Chem. Eur. J. 2010, 16, 12342-12348.

699. Preparation of arylsulfonyl chlorides by chlorosulfonylation of in situ generated diazonium salts using a continuous flow reactor L. Malet-Sanz, J. Madrzak, S.V. Ley, I.R. Baxendale, Org. Biomol. Chem. 2010, 8, 5324-5332. 698. Antivascular and anticancer activity of dihalogenated A-ring analogues of combretastatin A-4 T.M. Beale, R.M. Myers, J.W. Shearman, D.S. Charnock-Jones, J.D. Brenton, F.V. Gergeley, S.V. Ley, Med. Chem. Commun. 2010, 1, 202-208.

697. Total syntheses of the bromotyrosine-derived natural products ianthelline, 5-bromoverongamine and JBIR-44 J.W. Shearman, R.M. Myers, T.M. Beale, J.D. Brenton, S.V. Ley, Tetrahedron Lett. 2010, 51, 4812-4814.

696. Total synthesis of chloptosin A.J. Oelke, D.J. France, T. Hofmann, G. Wuitschik, S.V. Ley, Angew. Chem. Int. Ed. 2010, 49, 6139-6142 695. KMnO4 mediated oxidation as a continuous flow process J. Sedelmeier, S.V. Ley, I.R. Baxendale, M. Baumann, Org. Lett., 2010, 12, 3618-3621.

694. Enzymatic oxidative cyclisation reactions leading to dibenzoazocanes F. Tozzi, S.V.Ley, M.O. Kitching, I.R. Baxendale, Synlett 2010, 13, 1919-1922.

693. A palladium wall coated microcapillary reactor for use in continuous flow transfer hydrogenation C.H. Hornung, B. Hallmark, M.R. Mackley, I.R. Baxendale, S.V. Ley, Adv. Synth. Catal. 2010, 352, 1736-1745.

692. The changing face of organic synthesis S.V. Ley, Tetrahedron 2010, 66, 6270-6292

691. Electronic encyclopaedia of reagents in organic synthesis Ed. L.A. Paquette. Magnesium Nitride by K. Bridgwood, S.V. Ley, DOI: 10.1002/047084289X.rn01264.

690. Multiple microcapillary reactor for organic synthesis C.H. Hornung, B. Hallmark, M. Baumann, I.R. Baxendale, S.V. Ley, P. Hester, P. Clayton, M.R. Mackley, Ind. Eng. Chem. Res. 2010,49, 4576-4582.

689. Application of flow chemistry microreactors in the preparation of casein kinase I inhibitors F. Venturoni, N. Nikbin, S.V. Ley, I.R. Baxendale, Org. Biomol. Chem. 2010, 8, 1798-1806. 688. Flow ozonolysis using a semi-permeable Teflon™ AF-2400 membrane to effect gas-liquid contact M. O’Brien, I.R. Baxendale, S.V. Ley, Org. Lett. 2010, 12, 1596-1598.

687. An automated flow-based synthesis of imatinib: the API of gleevec M.D. Hopkin, I.R. Baxendale, S.V. Ley, J.C.S. Chem. Commun. 2010, 46, 2450-2452.

686. ReactIR™ flow cell: a new analytical tool for continuous flow chemistry processing C.F. Carter, H. Lange, I.R. Baxendale, S.V. Ley, J. Goode, N. Gaunt, B. Wittkamp, Org. Proc. Res. Dev. 2010, 14, 393-404.

685. The continuous flow synthesis of butane 2,3-diacetal protected building blocks using microreactors C.F. Carter, I.R. Baxendale, J.B.J. Pavey, S.V. Ley, Org. Biomol. Chem. 2010, 8, 1588-1595.

684. Synthesis of nitropyrrolidines via dipolar cycloaddition reactions using a modular flow reactor M. Baumann, I.R. Baxendale, S.V. Ley, Synlett 2010, 749-752.

683. A flowprocess using microreactors for the preparation of a quinolone derivative as a potent 5HTIB antagonist Z. Qian, I. R. Baxendale, S.V. Ley, Synlett, 2010, 505-508.

682. Total synthesis of the anti-apoptotic agents Iso- and bongkrekic acids A. Francais, A. Leyva, G. Etxebarria-Jardi, I. R. Baxendale, S.V. Ley, Org. Lett. 2010, 12, 340-343.


681. Multi-step synthesis using modular flow reactors: the preparation of yne-ones and their use in heterocycle synthesis I.R. Baxendale, S.C. Schou, J. Sedelmeier, S.V. Ley, Chem. Eur. J. 2010, 16, 89-94.

680. An asymmetric tandem conjugative addition-intramolecular cyclisation process to provide functionalised 3,6-dihydropyrans and 4,5-epoxytetrahydropyrans S. Catalán-Munoz, C.A. Müller, S.V. Ley, Eur. J. Org, Chem. 2010, 183-190.