876. Across-the-World Automated Optimization and Continuous-Flow Synthesis of Pharmaceutical Agents Operating Through a Cloud-Based Server D.E. Fitzpatrick, T. Maujean, A.C. Evans, and S.V. Ley Angew. Chem. Int. Ed. 2018, 57, 15128 –15132
875. Three-Component Assembly of Multiply Substituted Homoallylic Alcohols and Amines Using a Flow Chemistry Photoreactor Y. Chen, D.C. Blakemore, P. Pasau and S.V. Ley Org. Lett. 2018, 20, 6569-6572
874. C–H functionalisation of aldehydes using light generated, non-stabilised diazo compounds in flow P. Dingwall, A. Greb, L. N. S. Crespin, R. Labes, B. Musio, J.S. Poh, P. Pasau, D. C. Blakemore and S. V. Ley Chem. Comm. 2018, 54, 11685 – 11688
873. In-line separation of multicomponent reaction mixtures using a new semi-continuous supercritical fluid chromatography system D. E. Fitzpatrick, R. J. Mutton and S. V. Ley React. Chem. Eng., 2018, 3, 799-806
872. Integrated plug flow synthesis and crystallisation of pyrazinamide, C. D. Scott, R. Labes, M. Depardieu, C. Battilocchio, M. G. Davidson, S. V. Ley, C. C. Wilson and K. Robertson React. Chem. Eng., 2018, 3, 631-634
871. Immobilised Reagents and Multistep Processes, S.V. Ley, D.L. Browne, and M. O’Brien Science of Synthesis, 2018, 9, 273-312 in Flow Chemistry in Organic Synthesis, Ed. T.F. Jamison and G. Koch, Georg Thieme Verlag KG, Stuttgart, Germany, ISBN 978-3-13-242331-2.
Multistep continuous-flow processing enables the direct preparation of complex chemical materials from simple input streams through a series of complexity-adding reaction steps. The use of polymer-supported reagents can greatly facilitate this process through the inline hosting of reagents or catalysts, the scavenging of spent materials or impurities, or even the temporary hosting of reactive intermediates prior to their reaction and release from the support. This chapter provides a comprehensive overview of such polymer-supported techniques.
869. Engineering Chemistry to Enable Bioactive Small Molecule Discovery S.V.Ley, D. Fitzpatrick and C. Battilocchio 2018, 184-218 (Ch. 8) in Chemical and Biological Synthesis: Enabling Approaches for Understanding Biology, Ed. N.J. Westwood and A. Nelson, ISBN 978-1-78262-948-1
868. Highly diastereoselective boron and titanium mediated aldol reactions of a mannitol derived 2,3-butanediacetal ethyl ketone M.O’Brien, A. Weber, G. Hardy, S.V. Ley Tetrahedron, 2018, 74, 5319-5329
867. A Convergent Continuous Multistep Process for the Preparation of C4-Oxime-Substituted Thiazoles E. Godineau, C. Battilocchio, M. Lehmann, S. V. Ley, R. Labes, L. Birnoschi, S. Subramanian, C. S. Prasanna, A. Gorde, M. Kalbagh, V. Khade, A. Scherrer, and A. C. O’Sullivan Org. Process Res. Dev. 2018, 22, 955-962
866. Organic photocatalysis for the radical couplings of boronic acid derivatives in batch and flow F. Lima, L. Grunenberg, H.B.A. Rahman, R. Labes, J. Sedelmeier and S.V. Ley Chem. Commun., 2018, 54, 5606-5609
865. Engineering chemistry for the future of organic synthesis D.E. Fitzpatrick and S.V. Ley Tetrahedron, 2018, 74, 3087-3100
864. Engineering chemistry for the future of organic synthesis S.V. Ley Tetrahedron, 2018, 74, 3085 (Preface)
863. Mimicking the surface and prebiotic chemistry of early Earth using flow chemistry D. J. Ritson, C. Battilocchio, S.V. Ley and J. D. Sutherland Nature Communications 2018, 9, 1821[DOI:10.1038/s41467-018-04147-2 | www.nature.com/naturecommunications]
When considering life’s aetiology, the first questions that must be addressed are “how?” and“where?” were ostensibly complex molecules, considered necessary for life’s beginning, constructed from simpler, more abundant feedstock molecules on primitive Earth. Previously, we have used multiple clues from the prebiotic synthetic requirements of (proto)biomole- cules to pinpoint a set of closely related geochemical scenarios that are suggestive of flow and semi-batch chemistries. We now wish to report a multistep, uninterrupted synthesis of a key heterocycle (2-aminooxazole) en route to activated nucleotides starting from highly plausible, prebiotic feedstock molecules under conditions which mimic this scenario. Further consideration of the scenario has uncovered additional pertinent and novel aspects of pre- biotic chemistry, which greatly enhance the efficiency and plausibility of the synthesis.
862. The Engineering of Chemical Synthesis: Humans and Machines Working in Harmony Steven V. Ley Angew. Chem. Int. Ed. 2018, 57, 5182 – 5183
861. Diastereoselective Synthesis of Functionalized Indolines Using in situ Generated Allyl Boronic Species J. A. Forni, S-H. Lau, J-S. Poh, C. Battilocchio, S.V. Ley and J.C. Pastre Synlett 2018, 29, 825–829 860. Rapid, selective and stable HaloTag-LbADH immobilization directly from crude cell extract for the continuous biocatalytic production of chiral alcohols and epoxides J. Döbber, M. Pohl, S. V. Ley and B. Musio React.Chem.Eng., 2018, 3, 8–12 859. Real-Time Spectroscopic Analysis Enabling Quantitative and Safe Consumption of Fluoroform during Nucleophilic Trifluoromethylation in Flow B. Musio, E. Gala, and S. V. Ley ACS Sustainable Chem. Eng. 2018, 6, 1489−1495 858. A Versatile Route to Unstable Diazo Compounds via Oxadiazolines and their Use in Aryl–Alkyl Cross-Coupling Reactions A. Greb, J-S. Poh, S. Greed, C. Battilocchio, P. Pasau, D. C. Blakemore and S. V. Ley Angew. Chem. Int. Ed. 2017, 56, 16602 –16605 857. Visible-Light-Mediated Annulation of Electron-Rich Alkenes and Nitrogen-Centered Radicals from N-Sulfonylallylamines: Construction of Chloromethylated Pyrrolidine Derivatives L.N.S. Crespin, A. Greb, D.C. Blakemore, and S.V. Ley J. Org. Chem. 2017, 82, 13093−13108 856. Rapid Continuous Ruthenium-Catalysed Transfer Hydrogenation of Aromatic Nitriles to Primary Amines R. Labes, D. González-Calderón, C. Battilocchio, C. Mateos, G.R. Cumming, O. de Frutos, J. A. Rincón, and S. V. Ley, Synlett 2017, 28, 2855-2858 855. Continuous direct anodic flow oxidation of aromatic hydrocarbons to benzyl amides M.A. Kabeshov, B. Musio and S.V. Ley, React. Chem. Eng., 2017, 2, 822-825 854. A Lewis Base Catalysis Approach for the Photoredox Activation of Boronic Acids and Esters F. Lima, U.K. Sharma, L. Grunenberg, D. Saha, S. Johannsen, J. Sedelmeier, E.V. Van der Eycken and S.V. Ley, Angew. Chem. Int. Ed., 2017, 56, 15136-15140 853. Continuous Preparation and Use of Dibromoformaldoxime as a Reactive Intermediate for the Synthesis of 3-Bromoisoxazolines C. Battilocchio, F. Bosica, S.M. Roew, B.L. Abreu, E. Godineau, M. Lehmann and S.V. Ley, Org. Process Res. Dev., 2017, 21, 1588-1594 852. Chemoselective Continuous Ru-Catalyzed Hydrogen-Transfer Oppenauer-Type Oxidation of Secondary Alcohols R. Labes, C. Battilocchio, C. Mateos, G.R. Cumming, O. de Frutos, J.A. Rincón, K. Binder and S.V. Ley, Org. Process. Res. Dev., 2017, 21, 1419-1422 851. Unveiling the role of boroxines in metal-free carbon-carbon homologations using diazo compounds and boronic acids C. Bomio, M.A. Kabeshov, A.R. Lit, S-H. Lau, J. Ehlert, C. Battilocchio and S.V. Ley, Chem. Sci., 2017, 8, 6071-6075
850. A new methodology for incorporating chiral linkers into stapled peptides J.C. Serrano, J. Sipthorp, W. Xu, L.S. Itzhaki and S.V. Ley, Chem. Bio. Chem., 2017, 18, 1066-1071
849. Flow synthesis of cyclobutanones via [2 + 2] cycloaddition of keteneiminium salts and ethylene gas C. Battilocchio, G. Iannucci, S. Wang, E. Godineau, A. Kolleth, A. De Mesmaeker and S.V. Ley, React. Chem. Eng., 2017, 2, 295-298
848. Utilization of flow chemistry in catalysis: new avenues for the selective synthesis of bis(indolyl)methanes S.S. Mohapatra, Z.E. Wilson, S. Roy, S.V. Ley, Tetrahedron, 2017, 73, 1812-1819
847. One-pot acid-Catalyzed ring-opening/cyclization/oxidation of aziridines with N-tosylhydrazones: access to 1,2,4-triazines L. Crespin, L. Biancalana, T. Morack, D.C. Blakemore, S.V. Ley Org. Lett., 2017, 19, 1084-1087
846. Rapid asymmetric synthesis of disubstituted allenes by coupling of flow-generated diazo compounds and propargylated amines J-S. Poh, S. Makai, T. v.Keutz, D.N. Tran, C. Battilocchio, P. Pasau, S.V. Ley Angew. Chem. Int. Ed. 2017, 56, 1864-1868
845. Continuous flow hydration of pyrazine-2-carbonitrile in a manganese dioxide column reactor C. Battilocchio, S-H. Lau, J.M. Hawkins, S.V. Ley Org. Synth. 2017, 94, 34-45
844. On the synthesis and reactivity of 2,3-dihydropyrrolo[1,2-a]quinazolin-5(1H)-ones C.L. Sutherell and S.V. Ley Synthesis, 2017, 49, 135-144
843. Engineering chemistry: integrating batch and flow reactions on a single, automated reactor platform D.E. Fitzpatrick and S.V. Ley, React. Chem. Eng. 2016, 1, 629-635
842. Visible light activation of boronic esters enables efficient photoredox C(sp2)-C(sp3) cross-couplings in flow F. Lima, M.A. Kabeshov, D.N. Tran, C. Battilocchio, J. Sedelmeier, G. Sedelmeier, B. Schenkel, S.V. Ley, Angew. Chem. Int. Ed. 2016, 55, 14085-14089
841. The total synthesis of the bioactive natural product Plantazolicin A and its biosynthetic precursor Plantazolicin B S. Fenner, Z.E. Wilson, S.V. Ley, Chem. Eur. J. 2016, 22, 15902-15912
840. A multicomponent approach for the preparation of homoallylic alcohols J-S. Poh, S-H. Lau, I.G. Dykes, D.N. Tran, C. Battilocchio, S.V. Ley, Chem. Sci. 2016, 7, 6803-6807
839. Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia S. Picaud, K. Leonards, J-P. Lambart, O. Dovey, C. Wells, O. Federov, O. Monteiro, T. Fujisawa, C-Y. Wang, H. Lingard, C. Tallant, N. Nikbin, L. Guetzoyan, R.J. Ingham, S.V. Ley, P. Brennan, S. Müller, A. Samsonova, A-C. Gingras, J. Schwaller, G. Vassiliou, S. Knapp, P. Fiippakopoulos, Science Adv. 2016, 2, e1600760
838. Flow Chemistry in Europe V. Hessel and S.V. Ley, J. Flow. Chem., 2016, 6, 135
837. Combination of enabling technologies to improve and describe the stereoselectivity of Wolff–Staudinger cascade reaction B. Musio, F. Mariani, E.P. Sliwinski, M.A. Kabeshov, H. Odajima, S.V. Ley, Synthesis, 2016, 48, 3515-3526
836. Continuous processing and efficient in situ reaction monitoring of hypervalent iodine(III) mediated cyclopropanation using benchtop NMR spectroscopy B. Ahmed-Omer, E. Sliwinski, J.P. Cerroti, S.V Ley, Org. Process Res. Dev. 2016, 20, 1603-1614
835. Taming hazardous chemistry by continuous flow technology M. Movsisyan, E.I.P. Delbeke, J.K.E.T. Berton, C. Battilocchio, S.V. Ley, C.V. Stevens, Chem. Soc. Rev. 2016, 45, 4892-4928
Over the last two decades, flow technologies have become increasingly popular in the field of organic chemistry, offering solutions for engineering and/or chemical problems. Flow reactors enhance the mass and heat transfer, resulting in rapid reaction mixing, and enable a precise control over the reaction parameters, increasing the overall process selectivity, efficiency and safety. These features allow chemists to tackle unexploited challenges in their work, with the ultimate objective making chemistry more accessible for laboratory and industrial applications, avoiding the need to store and handle toxic, reactive and explosive reagents. This review covers some of the latest and most relevant developments in the field of continuous flow chemistry with the focus on hazardous reactions.
834. Editorial – flow chemistry and catalysis S.V. Ley, Catal. Sci. Technol. 2016, 6, 4676-4677
833. Synthesis of trifluoromethylated isoxazoles and their elaboration through inter- and intra-molecular C-H arylation J-S. Poh, C. García-Ruiz, A. Zúñiga, F. Meroni, D.C. Blakemore, D.L. Browne, S.V. Ley, Org. Biomol. Chem. 2016, 14, 5983-5991
832. Controlled generation and use of CO in flow S.V.F. Hansen, Z.E. Wilson, T. Ulven, S.V. Ley React. Chem. Eng. 2016, 1, 280-287
831. Identification and development of 2,3-dihydropyrrolo[1,2-a]quinazolin-5(1H)-one inhibitors targeting bromodomains within the switch/sucrose nonfermenting complex C.L. Sutherell, C. Tallant, O.P Monteiro, C. Yapp, J.E. Fuchs, O. Fedorov, P. Siejka, S. Müller, S. Knapp, J.D. Brenton, P.E. Brennan, S.V. Ley J. Med. Chem. 2016, 59, 5095-5101
830. Solvent-free continuous operations using small footprint reactors: a key approach for process intensification T. Ouchi, R.J. Mutton, V. Rojas, D.E. Fitzpatrick, D.G. Cork, C. Battilocchio, S.V. Ley ACS Sustainable Chem. Eng. 2016, 4, 1912-1916
829. Enabling technologies for the future of chemical synthesis D.E. Fitzpatrick, C. Battilocchio, S.V. Ley ACS Central Science 2016, 2, 131-138
828. Iterative reactions of transient boronic acids enable sequential C-C bond formation C. Battilocchio, F. Feist, A. Hafner, M. Simon, D.N. Tran, D.M. Allwood, D.C. Blakemore, S.V. Ley Nature Chem. 2016, 8, 360-367
827. Synthesis of natural and unnatural cyclooligomeric depsipeptides enabled by flow chemistry D. Lücke, T. Dalton, S.V. Ley, Z.E. Wilson Chem. Eur. J. 2016, 22, 4206-4217
826. (S)-5-Pyrrolidin-2-yltetrazole and (R)-5-Pyrrolidin-2-yltetrazole Second Update R.J. Mutton, S.V. Ley, Electronic Encyclopaedia of Reagents in Organic Synthesis. Ed. L.A. Paquette 2016
825. A novel internet-based reaction monitoring, Control and autonomous self-optimization platform for chemical synthesis D.E. Fitzpatrick, C. Battilocchio, S.V. Ley Org. Process. Res. Dev 2016, 20, 386-394
824. A multistep continuous flow synthesis machine for the preparation of pyrazoles via a metal-free amine-redox process J-S. Poh, D.L. Browne, S.V. Ley React. Chem. Eng. 2016, 1, 101-105
823. An orthogonal biocatalytic approach for the safe generation and use of HCN in a multistep continuous preparation of chiral O-acetylcyanohydrins A. Brahma, B. Musio, U. Ismayilova, N. Nikbin, S.B. Kamptmann, P. Siegert, G.E. Jeromin, S.V. Ley, M. Pohl Synlett 2016, 27, 262-266
822. Dynamic flow synthesis of porous organic cages M.E. Briggs, A.G. Slater, N. Lunt, S. Jiang, M.A. Little, R.L. Greenaway, T. Hasell, C. Battilocchio, S.V. Ley, A.I. Cooper Chem. Commun. 2015, 51, 17390-17393
821. Synthesis of a precursor to sacubitril using enabling technologies S-H. Lau, S.L. Bourne, B. Martin, B. Schenkel, G. Penn, S.V. Ley Org. Lett. 2015, 17, 5436-5439
820. The ‘Internet of Chemical Things‘ S.V. Ley, D.E. Fitzpatrick, R.J. Ingham, N. Nikbin Beilstein Magazine 2015, 1, 11-12
819. Callipeltosides A, B and C: total syntheses and structural confirmation J.R. Frost, C.M. Pearson, T.M. Snaddon, R.A. Booth, R.M. Turner, J. Gold, D.M. Shaw, M.J. Gaunt, S.V. Ley Chem. Eur. J. 2015, 21, 13261-13277
818. Machine-assisted organic synthesis S.V. Ley, D.E. Fitzpatrick, R.M. Myers, C. Battilocchio, R.J. Ingham Angew. Chem. Int. Ed. 2015, 54, 10122-10136
817. Design, synthesis and evaluation of semi-synthetic triazole-containing caffein acid analogues as 5-lipooxygenase inhibitors De Lucia, O Méndez Lucio, B. Musio, A. Bender, M. Listing, S. Dennhardt, A. Koeberle, U. Garscha, R. Rizzo, S. Manfredini, O. Werz, S.V. Ley Eur. J. Med. Chem. 2015, 101, 573-583
816. A practical deca-gram scale ring expansion of (R)-(−)-carvone to (R)-(+)-3-methyl-6-isopropenyl-cyclohept-3-enone-1 L. de c. Alves, A.L. Desiderá, K.T. de Oliveira, S. Newton, S.V. Ley, T.J Brocksom Org. Biomol. Chem. 2015, 13, 7633-7642
815. Continuous flow metathesis for direct valorization of food waste: an example of cocoa butter triglyceride C. Schotten, D. Plaza, S. Manzini, S.P. Nolan, S.V. Ley, D.L. Browne, A. Lapkin ACS Sustainable Chem. Eng. 2015, 3, 1453-1459
814. Machines vs malaria: a flow-based preparation of the drug candidate OZ439 S-H Lau, A. Galván, R.R. Merchant, C. Battilocchio, J.A. Souto, M.B. Berry, S.V. Ley Org. Lett. 2015, 17, 3218-3221
813. Modeling mesoscale reactors for the production of fine chemicals P.W. Witt, S. Somasi, I. Khan, D.W. Blaylock, J.A. Newby, S.V. Ley Chem. Eng. J. 2015, 278, 353-362
812. A versatile room-temperature route to di- and trisubstituted allenes using flow-generated diazo compounds J.S. Poh, D.N. Tran, C. Battilocchio, J.M Hawkins, S.V. Ley Angew. Chem. Int. Ed. 2015, 54, 7920-7923
811. Generation of reactive ketenes under flow conditions through zinc-mediated dehalogenation A. Hafner, S.V. Ley Synlett, 2015, 26, 1470-1474
810. Facilitating biomimetic syntheses of borrerine derived alkaloids by means of flow-chemical methods S.B. Kamptmann, S.V. Ley Aust. J. Chem. 2015, 68, 693-696
809. Development of a web-based platform for studying lithiation reactions in silico M.A. Kabeshov, E. Sliwinski, D.E. Fitzpatrick, B. Musio, J.A. Newby, W.D.W. Blaylock, S.V. Ley Chem. Commun. 2015, 51, 7172-7175
808. Development of a flow method for the hydroboration/oxidation of olefins J.A. Souto, R.A. Stockman, S.V.Ley Org. Biomol. Chem. 2015, 13, 3871-3877
807. Design, synthesis and evaluation of tetra substituted pyridines as potent 5-HT2C receptor agonists G. Rouquet, D.E. Moore, M. Spain, D.M. Allwood, C. Battilocchio, D.C. Blakemore, P.V. Fish, S. Jenkinson, A.S. Jessiman, S.V. Ley, G. McMurray, R.A.Storer, ACS Med. Chem. Lett. 2015, 6, 329-333
806. Chemistry in a changing world S.V. Ley, R.M. Myers, D.E. Fitzpatrick L’Actualite Chimique, Fevrier-Mars 2015, 393-394, 96-101
805. Organic synthesis: march of the machines S.V. Ley, D.E.Fitzpatrick, R.J. Ingham, R.M. Myers Angew. Chem. Int. Ed. 2015, 54, 3449-3464
804. Flow cyclopropanation using in-situ generated diazo compounds N.M. Roda-Monsalvez, D.N. Tran, C. Battilocchio, R. Labes, R.J. Ingham, J.M.Hawkins, S.V. Ley Org. Biomol. Chem. 2015, 13, 2550-2554
803. Flow chemistry: intelligent processing of gas-liquid transformations using a tube-in-tube reactor M. Brzozowski, M. O’Brien, S.V. Ley, A. Polyzos Acc. Chem. Res. 2015, 48, 349-362
802. Back pressure regulation of slurry-forming reactions in continuous flow B.J. Deadman, D.L. Browne, I.R. Baxendale, S.V. Ley Chem. Eng. Technol. 2015, 38, 259-264
801. Flow chemistry as a discovery tool to access sp2–sp3 cross-coupling reactions via diazo compounds D.N. Tran, C. Battilocchio, S. Lou, J. M. Hawkins, S.V. Ley Chem. Sci. 2015, 6, 1120-1125
800. Total syntheses of linear polythiazole/oxazole plantazolicin A and its biosynthetic precursor plantazolicin B Z.E. Wilson, S. Fenner, S.V. Ley Angew. Chem. Int. Edn. 2015, 54, 1284-1288
799. A systems approach towards an intelligent and self-controlling platform for integrated continuous reaction sequences R.J. Ingham, C. Battilocchio, D.E. Fitzpatrick, E. Sliwinski, J.M. Hawkins, S.V. Ley Angew. Chem. Int. Edn. 2015, 54, 144-148
798. The rapid synthesis of oxazolines and their heterogeneous oxidation to oxazoles under flow conditions S. Glockner, D.N. Tran, R.J. Ingham, S. Fenner, Z.E. Wilson, C. Battilocchio, S.V. Ley Org. Biomol. Chem. 2015, 13, 207
797. Process intensification for the continuous flow hydrogenation of ethyl nicotinate T. Ouchi, C. Battilocchio, J.M. Hawkins, S.V. Ley Org. Process Res. Dev., 2014, 18, 1560-1566
796. Reconfiguration of a continuous flow platform for extended operation: application to a cryogenic fluorine-directed ortho-lithiation reaction J.A. Newby, D.W. Blaylock, P.M. Witt, R.M. Turner, P.L. Heider, B.H. Harji, D.L. Browne, S.V. Ley Org. Process Res. Dev., 2014, 18, 1221-1228
795. Design and application of a low-temperature continuous flow chemistry platform J.A. Newby, D.W. Blaylock, P.M. Witt, J.C. Pastre, M.K. Zacharova, S.V. Ley, D. L. Browne, Org. Process Res. Dev. 2014, 18, 1211-1220
794. A general continuous flow method for palladium catalysed carbonylation reactions using single and multiple tube-in-tube gas-liquid microreactors U.Gross, P.Koos, M.O’Brien, A.Polyzos, S.V.Ley, Chem. Eur. J. 2014, 6418-6430
793. Regioselective preparation of saturated spirocyclic ring-expanded fused pyrazoles R.R. Merchant, D.M.Allwood, D.C.Blakemore, S.V.Ley, J. Org. Chem. 2014, 880-8811
792. Flow chemistry meets advanced functional materials R.M. Myers, D.E. Fitzpatrick, R.M. Turner, S.V. Ley Chem. Eur. J. 2014, 20, 12348-12366
791. Expedient preparation of nazlinine and a small library of indole alkaloids using flow electrochemistry as an enabling technology M.A. Kabeshov, B. Musio, P.R.D. Murray, D.L. Browne, S.V. Ley Org. Lett. 2014, 16, 4618-4621
790. Highly regioselective lithiation of pyridines bearing an oxetane unit by n-butyllithium G. Rouquet, D.C. Blakemore, S.V. Ley Chem. Comm. 2014, 50, 8908-8911
789. Synthesis of riboflavines, quinoxalinones and benzodiazepines through chemoselective flow based hydrogenations, M. Baumann, I.R. Baxendale, C.H. Hornung, S.V. Ley, M.V. Rojo, K.A. Roper Molecules 2014, 19, 9736-9759
788. Preparation of unsymmetrical ketones from tosylhydrazones and aromatic aldehydes via formyl C-H bond insertion, D.M. Allwood, D.C. Blakemore, S.V. Ley Org. Lett. 2014, 16, 3064-3067
787. Synthesis and use of trifluoromethylated azomethine ylide precursor: ethyl 1-benzyl-trans-5-(trifluoromethyl) pyrrolidine-3-carboxylate D.M. Allwood, D.L. Browne, S.V. Ley, Org. Synth. 2014, 91, 162-174
786. Continuous flow chemistry: a discovery tool for new chemical reactivity patterns J. Hartwig, J.B. Metternich, N. Nikbin, A. Kirschning, S.V. Ley, Org. Bio. Chem. 2014, 12, 3611
785. Accelerating spirocyclic polyketide synthesis using flow chemistry S. Newton, C.F. Carter, C.M. Pearson, L.C. Alves, H. Lange, P. Thansandote, S.V. Ley, Angew. Chem. Int. Edn. 2014, 53, 4915-4920
784. Flow based cerium oxide-enhanced low-level palladium Sonogashira and Heck coupling reactions by perovskite type oxide catalysts C. Battilocchio, B.N. Bhawal, R. Chorghade, B.J. Deadman, J.M. Hawkins, S.V. Ley, Israel Journal of Chem. 2014, 54, 371-380
783. Machine-assisted synthesis of modulators of the histone reader BRD9 using flow methods of chemistry and frontal affinity chromatography L. Guetzoyan, R. Ingham, N. Nikbin, J. Rossignol, M. Wolling, M. Baumert, N.A. Burgess-Brown, C.M. Strain-Damerell, L. Shrestha, P. Brennan, O. Fedorov, S. Knapp, S.V Ley, Med. Chem. Commun. 2014, 5, 540-546
782. Fully automated sequence-specific synthesis of alpha-peptides using flow chemistry K. Rahbek-Knudsen, M. Ladlow, Z. Bandpey, S.V. Ley, J. Flow. Chem. 2014, 4, 18-21
781. Integration of enabling methods for the automated flow preparation of piperazine-2-carboxamide R.J. Ingham, C. Battilocchio, J. M. Hawkins and S.V. Ley, Beilstein J. Org. Chem. 2014, 10, 641-652
780. Mild and selective heterogeneous catalytic hydration of nitriles to amides by flowing through manganese dioxide C. Battilocchio, J.M. Hawkins, S.V. Ley, Org. Lett. 2014, 16, 1060-1063
779. Metal-free coupling of saturated heterocyclic sulfonylhydrazones with boronic acids D.M. Allwood, D.C. Blakemore, A.D. Brown, S.V. Ley, J. Org. Chem. 2014, 79, 328-338
778. Investigation of a lithium-halogen exchange flow process for the preparation of boronates by using a cryo-flow reactor J.A. Newby, L. Huck, D.W. Blaylock, P.M. Witt, S.V. Ley, D.L. Browne, Chem. Eur. J., 2014, 20, 263-271
777. Fragment-based hit identification thinking in 3D A.D. Morley, A. Pugliese, K. Birchall, J. Bower, P. Brennan, N. Brown, T. Chapman, M. Drysdale, I.H. Gilbert, S. Hoelder, A. Jordan, S.V. Ley, A. Merritt, D. Miller, M.E. Swarbrick, P.G. Wyatt, Drug Discovery Today, 2013, 18, 1221-1227
776. Design, synthesis, and biological evaluation of an allosteric inhibitor of HSET that targets cancer cells with supernumerary centrosomes C.A. Watts, F.R. Richards, A. Bender, P.J. Bond, O. Korb, O. Kern, M. Riddick, P. Owen, R.M. Myers, J. Raff, F. Gergely, D.I. Jodrell, S.V. Ley, Chem. Biol. 2013, 20, 1399–1410
775. Sustainable flow Oppenauer oxidation of secondary benzylic alcohols with a heterogeneous zirconia catalyst R. Chorghade, C. Battilocchio, J.M. Hawkins, S.V. Ley, Org. Lett. 2013, 15, 5698-5701
774. Flow chemistry syntheses of natural products J.C. Pastre, D.L. Browne, S.V. Ley, Chem. Soc. Rev. 2013, 42, 8801-9198
773. Continuous flow-processing of organometallic reagents using an advanced peristaltic pumping system and the telescoped flow synthesis of (E/Z)-tamoxifen P.R.D. Murray, D.L. Browne, J.C. Pastre, C. Butters, D. Guthrie, S.V. Ley, Org. Proc. Res. Dev. 2013, 17, 1192-1208
772. Scaling-up of continuous flow processes with gases using a tube-in-tube reactor: in-line titrations and fanetizole synthesis with ammonia J. Pastre, D.L. Browne, M. O’Brien, S.V. Ley, Org. Proc. Res. Dev. 2013, 17, 1183-1191
771. The application of a monolithic triphenylphosphine reagent for conducting gem-dibromoolefination reactions in flow K.A. Roper, M.B. Berry, S.V. Ley, Beilstein J. Org. Chem. 2013, 9, 1781-1790
770. Flow synthesis and biological studies of an analgesic adamantane derivative that inhibits P2X7-evoked glutamate release C. Battilocchio, L. Guetzoyan, C. Cervetto, L. Di Cesare Mannelli, D. Frattaroli, I. R. Baxendale, G. Maura, A. Rossi, L. Sautebin, M. Biava, C. Ghelardini, M. Marcoli, S.V. Ley, A.C.S. Med. Chem. Lett. 2013, 4, 704-709
769. A continuous flow solution to achieving efficient, aerobic anti-Markovnikov Wacker oxidation S.L. Bourne, S.V. Ley, Adv. Synth. Catal. 2013, 355, 1905-1910
768. A prototype device for evaporation in batch and flow chemical processing B.J. Deadman, C. Battilocchio, E. Sliwinski, S.V. Ley, Green Chem., 2013, 15, 2050-2055
767. The synthesis of neurotensin antagonist SR 48692 for prostate cancer research I.R. Baxendale, S. Cheung, M.O. Kitching, S.V. Ley, J.W. Shearman Bio. Org. Med. Chem. 2013, 21, 4378-4387
766. Studies of a diastereoselective electrophilic fluorination reaction employing a cryo-flow reactor K. Nakayama, D.L. Browne, I.R. Baxendale, S.V. Ley, Synlett 2013, 24, 1298-1302
765. A machine-assisted flow synthesis of SR48692: a probe for the investigation of neurotensin receptor-1 C. Battilocchio, B.J. Deadman, N. Nikbin, M.O. Kitching, I.R. Baxendale, S.V. Ley, Chem. Eur. J. 2013, 19, 7917-7930.
764. Camera enabled techniques for organic synthesis S.V. Ley, R.J. Ingham, M. O’Brien, D.L. Browne, Beilstein J. Org. Chem. 2013, 9, 1051-1072.
763. Continuous cold without cryogenic consumables: development of a convenient laboratory tool for low temperature flow processes D.L. Browne, B.H. Harji, S.V. Ley, Chem. Eng. and Technol. 2013, 36, 959-967.
762. A mild and efficient flow procedure for the transfer hydrogenation of ketones and aldehydes using hydrous zirconia C. Battilocchio, J.M. Hawkins, S.V. Ley, Org. Lett. 2013, 15, 2278-2281.
761. Synthesis of spongistatin 2 employing a new route to the EF fragment H. Kraus, A. Français, M. O’Brien, J.R. Frost, A. Diéguez-Vázquez, A. Polara, N. Baricordi, R. Horan, D-S. Hsu, T. Tsunoda, S.V. Ley, Chem. Sci. 2013, 4, 1989-1994.
760. An expedtious synthesis of imatinib and analogues utilising flow chemistry methods M.D. Hopkin, I.R. Baxendale and S.V. Ley, Org. Biomol. Chem. 2013, 11, 1822-1839.
759. The synthesis of Bcr-Abl inhibiting anticancer pharmaceutical agents imatinib, nilotinib and dasatinib B. Deadman, M.D. Hopkin, I.R. Baxendale, S.V. Ley, Org. Biomol. Chem. 2013, 11, 1766-1800. 758. Synthesis of (-)-hennoxazole A: integrating batch and flow chemistry methods A. Fernández, Z.G. Levine, M. Baumann, S. Sulzer-Mossé, C. Sparr, S. Schläger, A. Metzger, I.R. Baxendale, S.V. Ley, Synlett, 2013, 24, 514-518. 757. Flow microwave technology and microreactors in synthesis I.R. Baxendale, C. Hornung, S.V. Ley, J. de M. Muñoz Molina, A. Wikström, Aust. J. Chem., 2013, 66, 131-144. 756. Flow chemistry synthesis of zolpidem, alpidem and other GABAA agonists and their biological evaluation through the use of in-line frontal affinity chromatography L. Guetzoyan, N. Nikbin, I.R. Baxendale, S.V. Ley, Chem. Sci., 2013, 4, 764-769. 755. Flow chemistry syntheses of styrenes, unsymmetrical stilbenes and branched aldehydes S.L. Bourne, M. O’Brien, S. Kasinathan, P. Koos, P. Tolstoy, D.X. Hu, R.W. Bates, B. Martin, B. Schenkel, S.V. Ley, ChemCatChem., 2013, 5, 159-172.
754. Synthesis and use of a new trifluoromethylated azomethine ylide precursor G. Tran, R. Meier, L. Harris, D.L. Browne, S.V. Ley, J. Org. Chem., 2012, 77, 11071-11078.
753. Synthesis of enantiomerically enriched 3-amino-2-oxindoles through a palladium-mediated asymmetric intramolecular arylation of α-ketimino amides P. Tolstoy, S.X.Y. Lee, C. Sparr, S.V. Ley, Org. Lett. 2012, 14, 4810-4813. 752. The evolution of immobilised reagents and their application in flow chemistry for the synthesis of natural products and pharmaceutical compounds by R.M. Myers, K.A. Roper, I.R. Baxendale and S.V. Ley. In “Modern Tools for the Synthesis of Complex Bioactive Molecules”, Ed. J. Cossy, S. Arseniyadis, J. Wiley, N.Y., ISBN 978-0-470-61618-5, 2012, Chapter 11, p. 359-394.
751. Total synthesis of callipeltosides A, B and C J.R. Frost, C.M. Pearson, T.N. Snaddon, R.A. Booth, S.V. Ley, Angew. Chem. Int. Ed. 2012, 51, 9366-9371.
750. Continuous multiple liquid–liquid separation: diazotization of amino acids in flow D.X. Hu , M. O’Brien, S.V. Ley, Org. Lett. 2012, 14, 4246-4249. 749. On being green: can flow chemistry help? S.V. Ley, Chem. Rec. 2012, 12, 378-390. 748. A prototype continuous-flow liquid–liquid extraction system using open-source technology M. O’Brien, P. Koos, D.L. Browne, S.V. Ley, Org. Biomol. Chem. 2012, 10, 7031-7036. 747. A “catch-react-release” method for flow synthesis of 2-aminopyrinidines and preparation of the imatinib base R.J. Ingham, E. Riva, N. Nikbin, I.R. Baxendale, S.V. Ley, Org. Lett. 2012, 14, 3920–3923. 746. Continuous flow reaction monitoring using an on-line miniature mass spectrometer D.L. Browne, S. Wright, B.J. Deadman, S. Dunnage, I.R. Baxendale, R.M. Turner, S.V. Ley, Rapid Commun. Mass Spectrom. 2012, 26, 1999-2010. 745. Flow synthesis using gaseous ammonia in a Teflon AF 2400 tube in tube reactor: Paal-Knorr formation and gas concentration measurement with in-line titration P.B. Cranwell, M. O’Brien, D. Browne, P. Koos, A. Polyzos, M. Pêna López, S.V. Ley, Org. Biomol. Chem. 2012, 10, 5774-5779. 744. A total synthesis of the ammonium ionophore (–)-enniatin B D.X. Hu, M. Bielitza, P. Koos, S.V. Ley, Tetrahedron Lett. 2012, 53, 4077-4079. 743. Asymmetric homogenous hydrogenation in flow using tube-in-tube reactor S. Newton, S.V. Ley, E.C. Arce, D. Grainger, Adv. Synth. Catal. 2012, 354, 1805-1812. 742. Rotamers or diastereomers? An overlooked NMR solution D.X. Hu, P. Grice, S.V. Ley, J. Org. Chem. 2012, 77, 5198-5202.
741. The continuous flow processing of gaseous ammonia using a Teflon AF-2400 tube in tube reactor: the synthesis of thioureas and in-line titrations D.L. Browne, M. O’Brien, P. Koos, P.B. Cranwell, A. Polyzos, S.V. Ley, Synlett 2012, 1402-1406.
740. Continuous preparation of arylmagnesium reagents in flow with in-line IR monitoring T. Brodmann, P. Koos, A. Metzger, P. Knochel, S.V. Ley, Org. Proc. Res. Dev. 2012, 16, 1102-1113.
739. A flow based synthesis of 2-aminoadamantane-2-carboyxlic acid C. Battilocchio, I.R. Baxendale, M. Biava, M.O. Kitching and S.V. Ley, Org. Proc. Res. Dev. 2012, 16, 798-810.
738. A-ring dihalogenation increases the cellular activity of combretastatin-templated tetrazoles T.M. Beale, D.M. Allwood, A. Bender, P.J. Bond, J.D. Brenton, D.S. Charnock-Jones, S.V. Ley, R.M. Myers*, J.W. Shearman, J. Temple, J. Unger, C.A. Watts, J. Xian, ACS Med. Chem. Lett. 2012, 3, 177-181.
737. Increased endothelial cell selectivity of triazole-bridged dihalogenated A-ring analogues of combretastatin A1 T.M. Beale, P.J. Bond, J.D. Brenton, D.S.Charnock-Jones, S.V. Ley, R.M. Myers*, Bioorg. Med. Chem. 2012, 20, 1749-1759.
736. The oxygen mediated continuous flow synthesis of 1,3-butadiynes using Teflon AF-2400 to effect gas-liquid contact T.P. Peterson, A. Polyzos, M. O’Brien, T. Ulven, I.R. Baxendale, S.V. Ley, Chem. Sus. Chem. 2012, 5, 274-277.
734. Scale-up of flow assisted synthesis of C2-symmetric chiral PyBox-ligands C. Battilocchio, M. Baumann, I.R. Baxendale, M. Biava, M.O. Kitching, S.V. Ley, R.M. Martin*, S.A. Ohnmacht, N.D.C. Tappin, Synthesis 2012, 44, 635-647.
733. Continuous stream processing: a prototype magnetic field induced flow mixer P. Koos, D.L. Browne, S.V. Ley, Green Process. and Synth. 2012, 1, 11-18.
732. Twenty Five Years of Azadirachtins (1986-2011), H.E. Hummel, D.F. Hein, S.V. Ley, E.D. Morgan, W. Kraus, H. Schmutterer, Pesticides, 2011, 1-4, 49-56. 731. The application of a monolithic triphenylphospine reagent for conducting Appel reactions in flow microreactors K. Roper, H. Lange, A. Polyzos, M.B. Berry, I.R. Baxendale, S.V. Ley, Bielstein J. Org. Chem. 2011, 7, 1648-1655.
730. Piecing together the puzzle: understanding a mild, metal free reduction method for large scale synthesis of hydrazines D.L. Browne,* I.R. Baxendale, S.V. Ley, Tetrahedron 2011, 67, 10296-10303.
729. Syngas mediated C-C bond formation in flow: selective rhodium catalysed hydroformylation of styrenes S. Kasinathan, S.L. Bourne, P. Tolstoy, P. Koos, M. O’Brien, R.W. Bates, I.R. Baxendale, S.V. Ley, Synlett 2011, 2648-2651.
728. The continuous-flow Synthesis of styrenes using ethylene in a palladium catalysed Heck cross-coupling reaction S.L. Bourne, P. Koos, M. O’Brien, B. Martin, B. Schenkel, I.R. Baxendale, S.V. Ley, Synlett 2011, 2643-2647.
727. Teflon AF-2400 mediated gas-liquid contact in continuous flow methoxycarbonylations and in-line FTIR measurement of CO Concentration P. Koos, U. Gross, A. Polyzos, M. O’Brien, I.R. Baxendale, S.V. Ley, Org. Biomol. Chem. 2011, 9, 6903-6908.
726. Piperazic acid-containing natural products: isolation, biological relevance and total synthesis A.J. Oelke, D.J. France, T. Hofmann, G. Wiutschik, S.V. Ley, Nat. Prod. Rep., 2011, 28, 1445-1471.
725. The flow synthesis of heterocycles for natural products and medicinal chemistry applications M. Baumann, I.R. Baxendale, S.V. Ley, Mol. Div. 2011, 15, 613-630.
724. Synthesis of a drug-like focused library of trisubstituted pyrrolidines using integrated flow chemistry and batch methods M. Baumann, R.E. Martin, C. Kuratli, J. Schneider, I.R. Baxendale, S.V. Ley, A.C.S. Comb. Sci. 2011, 13, 405-413.
723. A new enabling technology for convenient laboratory scale continuous flow processing at low temperatures D.L. Browne, M. Baumann, B.H. Harji, I.R. Baxendale, S.V. Ley, Org. Lett. 2011, 13, 3312-3315.
722. The clerodane ring system: investigating the viability of a direct Diels-Alder approach A.T. Merritt, R.H. Pouwer, D.J. Williams, C.M. Williams, S.V. Ley Org. Biomol. Chem. 2011, 9, 4745-4747
721. Hydrogenation in flow: homogenous and heterogeneous catalysts using Teflon AF-2400 to effect gas-liquid contact at elevated pressure M. O’Brien, N. Taylor, A. Polyzos, I.R. Baxendale, S.V. Ley Chem. Sci. 2011, 2, 1250-1257
720. An integrated flow and batch-based approach for the synthesis of O-methyl siphonazole M. Baumann, I.R. Baxendale, M. Brasholz, J.J. Hayward, S.V. Ley, N. Nikbin Synlett 2011, 10, 1375-1380 719. Retinoic acid receptor signalling regulates choroid tissue closure through independent mechanisms in the ventral optic cup and periocular mesenchyme G. Lupo, G. Gestri, M. O’Brien, R.M. Denton, R.A. Chandraratna, S.V. Ley, W.A. Harris, S.W. Wilson, Proc. Natl. Acad. Sci. 2011, 108, 8698-8703
718. Continuous flow processing of slurries: evaluation of an agitated cell reactor D.L. Browne, B.J. Deadman, R. Ashe, I.R. Baxendale, S.V. Ley, Org. Proc. Res. Dev. 2011, 15, 693-697.
717. Allosteric modulation of hormone release from thyroxine and corticosteroid-binding globulins X. Qi, F. Loiseau, W.L. Chan, Y. Yan, Z. Wei, L-G. Milroy, R.M. Myers, S.V. Ley, R.J. Read, R.W. Carrell, A. Zhou,* J. Biol. Chem. 2011, 286, 16163-16173.
716. An overview of the key routes to the best selling 5-membered ring heterocyclic pharmaceuticals M. Baumann, I.R. Baxendale, S.V. Ley, N. Nikbin, Beilstein J. Org. Chem. 2011, 7, 442-495.
715. Less well Known enabling technologies for organic synthesis M. O’Brien, R. Denton, S.V. Ley, Synthesis 2011, 1157-1192.
714. Total synthesis of chloptosin: a dimeric cyclohexapeptide A.J. Oelke, F. Antonietti, L. Bertone, P.B. Cranwell, D.J. France, R.J.M. Goss, T. Hoffman, S. Knauer, S.J. Moss, P.C. Skelton, R.M. Turner, G. Wuitschik, S.V. Ley, Chem. Eur. J. 2011, 17, 4183-4194.
713. Oxidation reactions in segmented and continuous flow chemical processing using a N-(tert Butyl)phenylsulfinimidoyl chloride monolith H. Lange, M.J. Carpenter, A.X. Jones, C.J. Smith, N. Nikbin, I.R. Baxendale, S.V. Ley, Synlett 2011, 6, 869-873.
712.A breakthrough method for the accurate addition of reagents in multi-step segmented flow processing H. Lange, C.F. Carter, M.D. Hopkin, A. Burke, J.G. Goode, I.R. Baxendale, S.V. Ley, Chem. Sci. 2011, 2, 765-769.
711. Diastereoselective chain elongation reactions using microreactors for application in complex molecule assembly C.F. Carter, H. Lange, D. Sakai, I.R. Baxendale, S.V. Ley, Chem. Eur. J., 2011, 17, 3398-3405.
710. A fully automated, multistep flow synthesis of 5-amino-4-cyano-1,2,3-triazoles C.J. Smith, N. Nikbin, S.V. Ley, H. Lange, I.R. Baxendale, Org. Biomol. Chem., 2011, 9, 1938-1947.
709. Flow synthesis of organic azides and the multistep synthesis of imines and amines using a new monolithic triphenylphosphine reagent C.J. Smith, C.D. Smith, N. Nikbin, S.V. Ley, I.R. Baxendale, Org. Biomol. Chem. 2011, 9, 1927-1937.
708. The continuous flow synthesis of carboxylic acids using CO2 in a tube-in-tube gas permeable membrane reactor A. Polyzos, M. O’Brien, T. Pugaard-Petersen, I.R. Baxendale, S.V. Ley, Angew. Chem. Int. Ed. 2011, 50, 1190-1193. 707. Lab of the future: the importance of remote monitoring and control M.D. Hopkin, I.R. Baxendale, S.V. Ley, Chim. Oggi./Chemistry Today, 2011, 29, 28-32. 706. Safe and reliable synthesis of diazoketones and quinoxalines in a continuous flow reactor L. J. Martin, A.L. Marzinzik, S.V. Ley, I.R. Baxendale, Org. Lett. 2011, 13, 320-323.
705. Total synthesis of iso- and bongkrekic acids: natural antibiotics displaying potent antiapoptotic properties A. Francais, A. Leyva-Pérez, G. Etxebarria-Jardi, J. Peña, S.V. Ley, Chem. Eur. J. 2011, 17, 329-343. 704. Total synthesis of subereomollines A and B J.W. Shearman, R. M. Myers, J.D. Brenton, S.V. Ley, Org. Biomol. Chem. 2011, 9, 62-65. 703. Microwave and flow syntheses of Pseudomonas Quinolone Signal (PQS) and analogues J.T. Hodgkinson, W.R.J.D. Galloway, S. Saraf, I.R. Baxendale, S.V. Ley, M. Ladlow, M. Welch, D.R. Spring, Org. Biomol. Chem. 2011, 9, 57-61.
702. Synthesis of highly substituted 3-nitropyrrolidines and 3-nitropyrroles by a multicomponent multi-step flow sequence M. Baumann, I.R. Baxendale, J. Wegner, A. Kirschning, S.V. Ley, Heterocycles 2010, 82, 1297-1316.
701. Trapping of novel palindromic ligands within native transthyretin prevents amyloid formation S.E. Kolstoe, P.P. Mangione, V. Bellotti, G.W. Taylor, G.A. Tennent, S. Deroe, A.J. Morrison, A.J. Cobb, A. Coyne, M.G. McCammon, R. Gill, M.P. Smith, S.V. Ley, C.V. Robinson, S.P. Wood, M.B. Pepys, Proc. Nat. .Acad. Sci. 2010, 107, 20483-20488.
700. A continuous flow process using a sequence of microreactors with in-line IR analysis of the preparation of N, N-diethyl-4-(3-fluorophenylpiperidin-4-ylidenemethyl) benzamide as a potent and highly selective δ-opioid receptor agonist Z. Qian, I.R. Baxendale, S.V. Ley, Chem. Eur. J. 2010, 16, 12342-12348.
699. Preparation of arylsulfonyl chlorides by chlorosulfonylation of in situ generated diazonium salts using a continuous flow reactor L. Malet-Sanz, J. Madrzak, S.V. Ley, I.R. Baxendale, Org. Biomol. Chem. 2010, 8, 5324-5332. 698. Antivascular and anticancer activity of dihalogenated A-ring analogues of combretastatin A-4 T.M. Beale, R.M. Myers, J.W. Shearman, D.S. Charnock-Jones, J.D. Brenton, F.V. Gergeley, S.V. Ley, Med. Chem. Commun. 2010, 1, 202-208.
697. Total syntheses of the bromotyrosine-derived natural products ianthelline, 5-bromoverongamine and JBIR-44 J.W. Shearman, R.M. Myers, T.M. Beale, J.D. Brenton, S.V. Ley, Tetrahedron Lett. 2010, 51, 4812-4814.
696. Total synthesis of chloptosin A.J. Oelke, D.J. France, T. Hofmann, G. Wuitschik, S.V. Ley, Angew. Chem. Int. Ed. 2010, 49, 6139-6142 695. KMnO4 mediated oxidation as a continuous flow process J. Sedelmeier, S.V. Ley, I.R. Baxendale, M. Baumann, Org. Lett., 2010, 12, 3618-3621.
694. Enzymatic oxidative cyclisation reactions leading to dibenzoazocanes F. Tozzi, S.V.Ley, M.O. Kitching, I.R. Baxendale, Synlett 2010, 13, 1919-1922.
693. A palladium wall coated microcapillary reactor for use in continuous flow transfer hydrogenation C.H. Hornung, B. Hallmark, M.R. Mackley, I.R. Baxendale, S.V. Ley, Adv. Synth. Catal. 2010, 352, 1736-1745.
692. The changing face of organic synthesis S.V. Ley, Tetrahedron 2010, 66, 6270-6292
691. Electronic encyclopaedia of reagents in organic synthesis Ed. L.A. Paquette. Magnesium Nitride by K. Bridgwood, S.V. Ley, DOI: 10.1002/047084289X.rn01264.
690. Multiple microcapillary reactor for organic synthesis C.H. Hornung, B. Hallmark, M. Baumann, I.R. Baxendale, S.V. Ley, P. Hester, P. Clayton, M.R. Mackley, Ind. Eng. Chem. Res. 2010,49, 4576-4582. 689. Application of flow chemistry microreactors in the preparation of casein kinase I inhibitors F. Venturoni, N. Nikbin, S.V. Ley, I.R. Baxendale, Org. Biomol. Chem. 2010, 8, 1798-1806. 688. Flow ozonolysis using a semi-permeable Teflon™ AF-2400 membrane to effect gas-liquid contact M. O’Brien, I.R. Baxendale, S.V. Ley, Org. Lett. 2010, 12, 1596-1598.
687. An automated flow-based synthesis of imatinib: the API of gleevec M.D. Hopkin, I.R. Baxendale, S.V. Ley, J.C.S. Chem. Commun. 2010, 46, 2450-2452.
686. ReactIR™ flow cell: a new analytical tool for continuous flow chemistry processing C.F. Carter, H. Lange, I.R. Baxendale, S.V. Ley, J. Goode, N. Gaunt, B. Wittkamp, Org. Proc. Res. Dev. 2010, 14, 393-404.
685. The continuous flow synthesis of butane 2,3-diacetal protected building blocks using microreactors C.F. Carter, I.R. Baxendale, J.B.J. Pavey, S.V. Ley, Org. Biomol. Chem. 2010, 8, 1588-1595. 684. Synthesis of nitropyrrolidines via dipolar cycloaddition reactions using a modular flow reactor M. Baumann, I.R. Baxendale, S.V. Ley, Synlett 2010, 749-752. 683. A flowprocess using microreactors for the preparation of a quinolone derivative as a potent 5HTIB antagonist Z. Qian, I. R. Baxendale, S.V. Ley, Synlett, 2010, 505-508. 682. Total synthesis of the anti-apoptotic agents Iso- and bongkrekic acids A. Francais, A. Leyva, G. Etxebarria-Jardi, I. R. Baxendale, S.V. Ley, Org. Lett. 2010, 12, 340-343.
681. Multi-step synthesis using modular flow reactors: the preparation of yne-ones and their use in heterocycle synthesis I.R. Baxendale, S.C. Schou, J. Sedelmeier, S.V. Ley, Chem. Eur. J. 2010, 16, 89-94.
680. An asymmetric tandem conjugative addition-intramolecular cyclisation process to provide functionalised 3,6-dihydropyrans and 4,5-epoxytetrahydropyrans S. Catalán-Munoz, C.A. Müller, S.V. Ley, Eur. J. Org, Chem. 2010, 183-190.