2000-2009 Publications

679. Total Synthesis of (-)Spirangien A and the Corresponding Methyl Ester Commentary by P.B. Cranwell, S.V. Ley, Chemtracts 2009, 22, 173-181

678. Synthesis of Acetal Protected Building Blocks using Flow Chemistry and Flow I.R. Methods: Preparation of Butane 2, 3- Diacetal Tartrates C.F. Carter, I.R. Baxendale, M. O’Brien, J.B.J. Pavey, S.V. Ley, Org. Biomol. Chem. 2009, 7, 4594

677. Enantioselective Synthesis of the Lyngbouilloside Macrolactone Core D. Webb, A. van den Heuval, M. Kögl, S.V. Ley, Synlett 2009, 14, 2320-2324

676. Pd-EnCat™ TPP30 as a Catalyst for the Generation of Highly Functionalized Aryl- and Alkenyl-substituted Acetylenes via Microwave Assisted Sonogashira type Reactions J. Sedelmeier, S.V. Ley, H. Lange, I.R. Baxendale, Eur. J. Org. Chem. 2009, 4412-4420

675. Cancer, Chemistry, and the Cell: Molecules that Interact with the Neurotensin Receptors R.M. Myers,* J.W. Shearman, M.O. Kitching, A. Ramos-Montoya, D.E. Neal, S.V. Ley, ACS Chem. Biol. 2009, 4, 503-525

674. Development of Fluorination Methods using Continuous-Flow Microreactors M. Baumann, I.R. Baxendale, L.J. Martin, S.V. Ley, Tetrahedron 2009, 65, 6611-6625

673. Methyliminoacetic Acid (MIDA) Boronates: A New Strategy for Organic Synthesis Commentary C.F. Carter and S.V. Ley, Chemtracts 2009, 21, 457-465

672. Total Synthesis of the Potent Antifungal Agents Bengazole C and E
A. Enríquez-Garcia and S.V. Ley, Coll. Czech. Chem. Comm. 2009, 74, 887-900

671. Continuous Flow Based Catch and Release Protocol for the Synthesis of alpha-Ketoesters A. Palmieri, S.V. Ley, A. Polyzos, M. Ladlow and I.R. Baxendale, Beilstein J. Org. Chem. 2009, 5, No. 23

670. A Microfluidic Flow Chemistry Platform for Organic Synthesis: the Hofmann Rearrangement A. Palmieri, S.V. Ley, K. Hammond, A. Polyzos and I.R. Baxendale, Tetrahedron Lett. 2009, 50, 3287-3289.

669. MultiStep Synthesis using Modular Flow Reactors: Bestmann-Ohira Reagent for the Formation of Alkynes and Triazoles I.R. Baxendale, S.V. Ley, A.C. Mansfield, C.D. Smith, Angew. Chem. Int. Ed. 2009, 48, 4017-4021

668. An Efficient and Transition Metal Free Protocol for the Transfer Hydrogenation of Ketones as a Continuous Flow Process J. Sedelmeier, I.R. Baxendale and S.V. Ley, Green Chem. 2009, 11, 683-685.

667. A Base-Catalysed, One Pot, Three Component Coupling Reaction Leading to Nitrosubstituted Pyrroles I.R. Baxendale, C.D. Buckle, S.V. Ley, L. Tamborini, Synthesis, 2009, 9, 1485-1493.

666. AuCl3-Catalysed Hydroalkoxylation of Conjugated Alkynoates: Synthesis of Five and Six-Membered Cyclic Acetals A. Diéguez-Vázquez, C.C. Tzschucke, J. Crecente-Campo, S. McGrath, S.V. Ley, Eur. J. Org. Chem, 2009, 40, 1698-1706.

665. New Tools for Molecule Makers: Emerging Technologies S.V. Ley and I.R. Baxendale. Eds. M. Hicks and C. Kettner. Proc. of the Beilstien Symposium on Systems Chemistry, Bozen, Italy ISBN 978-8325-2188-2, 2009, 65-85

664. Total Synthesis of Rapamycin S.V. Ley, M.N. Tackett, M.L. Maddess, J.C. Anderson, P.E. Brennan, M.W. Cappi, J.P. Heer, C. Helgen, M. Kori, C. Kouklovsky, S.P. Marsden, J. Norman, D.P. Osborn, M.Á. Palomero, J.B.J. Pavey, C. Pinel, L.A. Robinson, J. Schnaubelt, J.S. Scott, C.D. Spilling, H. Watanabe, K.E. Wesson and M.C. Willis, Chem. Eur. J., 2009, 15, 2874-2914

663. Highly Diastereoselective Desymmetrisation of Cyclic Meso-Anhydrides and Derivatisation for use in Natural Product Syntheses A.C. Evans, D.A. Longbottom, M. Matsuoka, R.M. Turner, V. Frankevicvius, S.V. Ley, Org. Biomol. Chem., 2009, 7, 747-760

662. Second-Generation Synthesis of Azadirachtin : A Concise Preparation of the Propargylic Mesylate Fragment A. Boyer, G.E. Veitch, E. Beckmann and S.V. Ley, Angew. Chem. Int. Edn., 2009, 48, 1317-1320

661. Natural product-Like Spiroketals and Fused Bicyclic Acetals as Potential Therapeutic Agents for B-Cell Chronic Lymphocytic Leukemia L-G Milroy, G. Zinzalla, F. Loiseau, Z. Qian, G. Prencipe, C. Pepper and S.V. Ley Chem. Med. Chem., 2008, 3, 1922-1935

660. The Azadirachtin Story G.E. Veitch, A. Boyer and S.V. Ley, Angew. Chem. Int. Ed., 2008, 47, 9402-9429

659. The Synthesis of Azadirachtin: A Potent Insect Antifeedant S.V. Ley, A. Abad-Somovila, J.C. Anderson, C. Ayats, R. Bänteli, E. Beckmann, A. Boyer, M.G. Brasca, A. Brice, H. Broughton, B.J. Burke, E. Cleator, D. Craig, A.A. Denholm, T. Durand-Reville, L.B. Gobbi, M. Gröbel, B.L. Gray, R.B. Grossmann, C.E. Gutteridge, N. Hahn, S.L. Harding, D.C. Jennens, P.J. Lovell, H.J. Lovell, M.L. de la Puente, H.C. Kolb, W-J Koot, S.L. Maslen, C.F. McCusker, A. Mattes, A.R. Pape, A. Pinto, D. Santfianos, J.S. Scott, S.C. Smith, A.Q. Somers, C.D. Spilling, F. Stelzer, P.L. Toogood, R.M. Turner, G.E. Veitch, A. Wood, C. Zumbrunn, Chem. Eur. J., 2008, 14, 10683-10704

658. A Bifurcated Pathway to Thiazoles and Imidazoles Using a Modular Flow Microreactor I.R. Baxendale, S.V. Ley, C.D. Smith, L. Tamborini and A.F. Voica, J. Combinatorial Chem., 2008, 10, 851-857

657. Magnesium Nitride as a Convenient Source of Ammonia for the Paarl-Knorr Preparation of Pyrroles G.E. Veitch, K.L. Bridgwood, K. Rands-Trevor and S.V. Ley, Synlett, 2008, 17, 2597-2600

656. Enantiopure 2-Substituted Glyceraldehyde Derivatives by Aza-Claisen Rearrangement or C-Alkylation of Enamines K.L. Bridgwood, C.C. Tzschucke, M.O’Brien, S. Wittrock, J.M. Goodman, J.E. Davies, A.W.J. Logan, M.R.M. Hüttl, and S.V. Ley, Org. Lett., 2008, 10, 4537-4540

655. The Use of Diethylaminosulfur-Trifluoride (DAST) for the Fluorination in a Continuous Flow Reactor M. Baumann, I.R. Baxendale and S.V. Ley, Synlett, 2008, 14, 2111-2114

654. Magnesium Nitride as a Convenient Source of Ammonia: Preparation of Dihydropyridines K.L. Bridgwood, G.E. Veitch, and S.V. Ley, Org. Lett. 2008, 10, 3627-3629

653. Magnesium Nitride as a Convenient Source of Ammonia: Preparation of Primary Amides G.E. Veitch, K.L. Bridgwood and S.V. Ley, Org. Lett. 2008, 10, 3623-3625

652. New Opportunities for Advancing Organic Synthesis and Flow Based Chemical Processing M. Baumann, I.R. Baxendale, J.J. Hayward, M.D. Hopkin, J. Jin, M.O. Kitching, S. Lanners, S.V. Ley, N. Nikbin-Rousardi, C.D. Smith, C.J. Smith and L. Tamborini, J. Labelled Compd. and Pharmaceuticals 2008, 51, 252-253

651. A General Organocatalytic Enantioselective Malonate Addition to α,β-Unsaturated Enones V. Wascholowski, K.R. Knudsen, C.E.T. Mitchell and S.V. Ley, Chem. Eur. J., 2008, 14, 6155-6165.

650. FeCl3 Catalysed Cleavage of 2,3-Butanediacetal Protected Diols
C.C. Tzschucke, N. Pradidphol, A. Dieguez-Vazquez, B. Kongkathip, N. Kongkathip and S.V. Ley, Synlett, 2008, 9, 1293-1296

649. A New Focussed Microwave Approach to the Synthesis of Amino-Substituted Pyrroloisoquinolines and Pyrroloquinolines via a Sequential Multi-Component Coupling Process M.D. Hopkin, I.R. Baxendale and S.V. Ley, Synthesis, 2008, 1688-1702.

648. A New Synthesis of (-)-Epipyriculol: a Phytotoxic Metabolite A. Levya, F.E. Blum and S.V. Ley, Tetrahedron, 2008, 64, 4711-4717.

647. Azide Monoliths as Convenient Flow Reactors for Efficient Curtius Rearrangement Reactions M. Baumann, I.R. Baxendale, S.V. Ley, N. Nikbin and C.D. Smith, Org. Biomol. Chem. 2008, 6, 1587-1593.

646. A Modular Flow Reactor for Performing Curtius Rearrangements as a Continuous Flow Process M. Baumann, I.R. Baxendale, S.V. Ley, N. Nikbin, C.D. Smith and J.P. Tierney, Org. Biomol. Chem. 2008, 6, 1577-1586.

645. A General Organocatalytic Enantioselective Nitrocyclopropanation Reaction V. Wascholowski, H.M. Hansen, D.A. Longbottom and S.V. Ley, Synthesis, 2008, 8, 1269-1275.

644. The Changing Face of Organic Synthesis S.V. Ley and I.R. Baxendale, Chimia, 2008, 62, 162-168.

643. Organic Chemistry in Microreactors; Heterogenous Reactions I.R. Baxendale, J.J. Hayward, S. Lanners, S.V. Ley, C.D. Smith. “Microreactors in Organic Chemistry and Catalysis” ed. T. Wirth and J. Wiley.

642. Azeotropic Reflux Chromatography: An Efficient Solution to a Difficult Separation in the Scale-up of Spongistatin I M. O’Brien, A. Dieguez-Vázquez, D-S. Hsu, H. Kraus, Y. Sumino and S.V. Ley, Org. Biomol. Chem., 2008, 6, 1159-1164.

641. Total Synthesis Studies Towards the Macrocyclic Pipercolic Natural Products FK 506, Antascomycins and Rapamycin M.L. Maddess, M.N. Tackett and S.V. Ley, “Progress in Drug Research Vol 66: Natural Compounds as Drugs, Vol. II Eds. F. Peterson and R. Amstutz, 2008, Birkhauser Verlag AG Basel ISBN:978-3-7643-8594. P13-186.

640. Facile, One-Step Production of Niacin (Vitamin B3) and other Nitrogen-Containing Pharmaceutical Chemicals with a Single-Site Heterogeneous Catalyst R. Raja. J.M. Thomas, M. Greenhill-Hooper, S.V. Ley, and F.A. Almeida Paz, Chem. Eu. J., 2008, 14, 2340-2348.

639. Synthesis of Natural Products from the Indian Neem Tree Azadirachta indica G.E. Veitch, A. Pinto, A. Boyer, E. Beckmann, J.C. Anderson and S.V. Ley, Org. Lett., 2008, 10, 569-572.

638. Practical Organocatalysis with (S)- and (R)-5 Pyrrolidin-2-yl-1H-tetrazoles D.A. Longbottom, V. Frankevicivus, S. Kumarn, A.J. Oelke, V. Wascholowski and S.V. Ley, Aldrichimica Acta, 2008, 41, 3.

637. Functionalised Butanediacetal Protected 1,2-Diols as Suitable Substrates for Pd- Catalysed Cross Coupling Reactions A. Levya, F.E. Blum, P.R. Hewitt and S.V. Ley, Tetrahedron, 2008, 64, 2348-2358.

636. Synthesis of (S)-5-Pyrrolidin-2-yl-1H-Tetrazole V. Aureggi, V. Frankevicvius, M.O. Kitching, S.V. Ley, D.A. Longbottom, A.J. Oelke and G. Sedelmeier, Org. Synth. 2008, 85, 72-87.

635. PtCl4 Catalysed Domino Synthesis of Fused Bicyclic Acetals A. Diéguez-Vázquez, C.C. Tzschucke, Wing-Ye Lam and S.V. Ley, Angew. Chem. Int. Ed., 2008, 47, 209-212.

634. Microwave Reactions Under Continuous Flow Conditions I.R. Baxendale, J.J. Hayward and S.V. Ley, Comb. Chem. High T.Scr. 2007, 10, 802-836.

633. A New Relay Route for the Synthesis of Azadirachtin G.E. Veitch, E. Beckmann, B. J. Burke, A. Boyer, C. Ayats and S.V. Ley, Angew. Chem., Int. Ed. 2007, 46, 7633-7635.

632. Synthesis of Azadirachtin: A Long but Successful Journey, G.E. Veitch, E. Beckmann, B.J. Burke, A. Boyer, S.L. Maslen and S.V. Ley, Angew. Chem. Int. Ed. 2007, 46, 7629-7632.

631. Natural Products as an Inspiration for the Discovery of New High Throughput Chemical Synthesis Tools, S.V. Ley, I.R. Baxendale, D.A. Longbottom and R.M. Myers. Ed. M.S. Chorghade Book Chapter from “Drug Discovery & Development”, Vol. 2 Drug Development. John Wiley & Sons 2007. ISBN: 0-471-39847-9, p51-89.

630. Chiral Glycolate Equivalents for the Asymmetric Synthesis of alpha-Hydroxycarbonyl Compounds S.V. Ley, T.D. Sheppard, R.M. Myers and M.S. Chorghade, Bull. Chem. Soc. Jpn. 2007, 80, 1451-1472.

629. Flow and Batch Mode Focused Microwave Synthesis of 5-Amino-4-cyanopyrazoles and their further conversion to 4-Aminopyrazolopyrimidines C.J. Smith, J. Iglesias-Sigüenza, I.R. Baxendale and S.V. Ley, Org. Biomol. Chem. 2007, 5, 2758-2761.

628. A Sequential Enantioselective Organocatalytic Route to Chiral 1,2-Oxazines and Chiral Pyridazines S. Kumarn, A.J. Oelke, D.M. Shaw, D.A. Longbottom and S.V. Ley, Org. Biomol. Chem., 2007, 5, 2678-2689.

627. Electronic Encyclopaedia of Reagents for Organic Synthesis Ed. L.A. Paquette, J. Wiley, (E)-3-Iodoprop-2-enoic Acid; (Z)- Isomer, S.V. Ley and D.A. Longbottom, DOI: 10.1002/047084289X.rn00815.

626. A Fascination with 1,2-Diacetals S.V. Ley and A. Polara, J. Org. Chem., 2007, 72, 5943-5959.

625. Solid Supported Reagents in Multi-Step Flow Synthesis I.R. Baxendale and S.V. Ley, “New Avenues to Efficient Chemical Synthesis: Emerging Technologies”, Symposium Proceeding 06.3, Ed: P.H. Seeberger and T. Blume. Springer, Berlin Heidelburg, ISBN 978-3-540-70848-3, 2007, 3, 151-185.

624. Total Synthesis of Five Thapsigargins – Guaianolide Natural Products Exhibiting Subnanomolar SERCA Inhibition S.P. Andrews, M. Ball, F. Wierschem, E. Cleator, S. Oliver, K. Högenauer, O. Simic, A. Antonello, U. Hünger, M.D. Smith and S.V. Ley, Chem. Eur. J., 2007, 13, 5688-5712.

623. Total Synthesis of Potent Antifungal Marine Bisoxazole Natural Products Bengazoles A and B J.A. Bull, E.P. Balskus, R.A.J. Horan, M. Langner and S.V. Ley, Chem. Eur. J. 2007, 13, 5515-5538.

622. Science of Synthesis, Compounds with Two Carbon-Heteroatom Bonds, Vol. Ed. S.L. Warriner, Vol. 29, Product Class 9: Spiroketals, S.V. Ley, L-G. Milroy and R.M. Myers. Thieme-Verlag, Stuttgart, Germany, 2007 p 613-689.

621. Pharmaceutical Strategy and Innovation: An Academic’s Perspective, I.R. Baxendale, J.J. Hayward, S.V. Ley and G.K. Tranmer, Chem. Med. Chem., 2007, 2, 768-788.

620. (S)- and (R)-5-Pyrrolidin-2-yl-1H-tetrazoles: Enantiomeric Organocatalysts of Broad Utility in Organic Synthesis D.A. Longbottom, V. Franckevicvius‚Ä®and S.V. Ley, Chimia, 2007, 61, 247-256.

619. Continuous Flow Ligand-Free Heck Reactions Using Monolithic Pd[0] Nanoclusters N. Nikbin, M. Ladlow, S.V. Ley, Org. Proc. Res. Dev., 2007, 11, 458-462.

618. A Microcapillary Flow Disc (MFD) Reactor for Organic Synthesis, C.H. Hornung, M.R. Mackley, I.R. Baxendale and S.V. Ley and, Org. Proc. Res. Dev., 2007, 11, 399-405.

617. A Fully Automated Flow-Through Synthesis of Secondary Sulfonamides in a Binary Reactor System C.M. Griffiths-Jones, M.D. Hopkin, D. Jönssen, S.V. Ley, D.J. Tapolczay, E. Vickerstaffe and M. Ladlow, J. Comb. Chem. 2007, 9, 422-430.

616. Tagged Phosphine Reagents to Assist Reaction Work-up by Phase-Switched Scavenging Using a Modular Flow Reactor Process C.D. Smith, I.R. Baxendale, G.K. Tranmer, M. Baumann, S.C. Smith, R.A. Lewthwaite and S.V. Ley, Org. Biomol. Chem., 2007, 5, 1562-1568.

615. [3 + 2] Cycloaddition of Acetylenes with Azides to give 1,4-Disubstituted 1,2,3- Triazoles in a Modular Flow Reactor C.D. Smith, I.R. Baxendale, S. Lanners, J.J. Hayward, S.C. Smith and S.V. Ley, Org. Biomol. Chem. 2007, 5, 1559-1561.

614. Chromatography-Free Suzuki Reactions using a Polymer-Assisted Solution-Phase (PASP) Approach E. Vickerstaffe, A-L. Villard, M. Ladlow and S.V. Ley, Synlett, 2007, 1251-1254.

613. Design and Total Synthesis of Unnatural Analogues of the Sub-Nanomolar SERCA Inhibitor Thapsigargin S.P. Andrews, M. Tait, M. Ball and S.V. Ley, Org. Biomol. Chem. 2007, 5, 1427-1436.

612. Identification of a Putitive Azadirachtin-Binding Complex from Drosophila Kc167 Cells S.L. Robertson, W. Ni, T.S. Dhadialla, A.J. Nisbet, C. McCusker, S.V. Ley, W. Mordue and A.J. Mordue, Arch. Insect. Biochem. and Physiol. 2007, 64, 200-208.

611. Optimisation of Conditions for O-Benzyl and N-Benzyloxycarbonyl Protecting Group Removal using an Automated Flow Hydrogenator K.R. Knudsen, J. Holden, S.V. Ley and M. Ladlow, Adv. Syn. Cat. 2007, 349, 535-538.

610. Chemical Variation of Natural Product-Like Scaffolds: Design, Synthesis and Biological Activity of Fused Bicyclic Acetal Derivatives L-G Milroy, G. Zinzalla, G. Prencipe, P. Michel, S.V. Ley, M. Gunaratnam, M. Beltran and S. Neidle, Angew. Chem. Int. Ed. 2007, 46, 2493-2496.

609. Total Synthesis of Thapsigargin, A Potent SERCA Pump Inhibitor M. Ball, S.P. Andrews, F. Wierschem, E. Cleator, M.D. Smith and S.V. Ley, Org. Lett. 2007, 9, 663-666.

608. Total Synthesis of Rapamycin M.L. Maddess, M.N. Tackett, H. Watanabe, P.E. Brennan, C.D. Spilling, J.S. Scott, D.P. Osborn and S.V. Ley, Angew. Chem., Int. Ed. 2007, 46, 591-597.

607. Polymer-Supported Reagents and Scavengers in Synthesis S.V. Ley, I.R. Baxendale and R.M. Myers, in “Comprehensive Medicinal Chemistry II, Vol.3, Drug Discovery Technologies. Eds. D.J. Triggle and J.B. Taylor, Elsevier, Oxford, 2006, 791-836. ISBN: 0080445136.

606. A New Asymmetric Organocatalytic Nitrocyclopropanation Reaction H.M. Hansen, D.A. Longbottom and S.V. Ley, J. Chem. Soc., Chem. Commun. 2006, 4838-4840.

605. A Flow Reactor Process for the Synthesis of Peptides Utilizing Immobilised Reagents, Scavengers and Catch and Release Protocols, I.R. Baxendale, S.V. Ley, C.D. Smith and G.K. Tranmer, J. Chem. Soc., Chem. Commun. 2006, 4835-4837.

604. A Fully Automated Continuous Flow Synthesis of 4,5-Disbustituted Oxaxoles M. Baumann, I.R. Baxendale, S.V. Ley, C.D. Smith and G.K. Tranmer, Org. Lett. 2006, 8, 5231-5234.

603. Asymmetric Organocatalysis S.V. Ley, in “Asymmetric Synthesis – The Essentials”. M. Christmann and Ed. S. Bräse. Wiley-VCH. 2006 ISBN-978-3-527-31399-0, 211-216

602. Stereocontrolled Total Synthesis of Bengazole A: A Marine Bisoxazole Natural Product Displaying Potent Antifungal Properties J.A. Bull, E.P. Balskus, R.A.J. Horan, M. Langner and S.V. Ley, Angew. Chem. Int. Ed. 2006, 45, 6714-6718.

601. An Enantioselective Organocatalytic Route to Chiral 3,6-Dihydropyridazines from Aldehydes A.J. Oelke, S. Kumarn, D.A. Longbottom, S.V. Ley, Synlett, 2006, 2548-2552.

600. 8,9,10,10a-Tetrahydro-6H-tetrazolo[1,5-a]pyrrolo[2,1-c]pyrazines: New Heterocyclic Structures Generated by an Ugi-Type Three Component Reaction V. Franckevicvius, D.A. Longbottom, R.M. Turner and S.V. Ley, Synthesis 2006, 3215-3223.

599. Enantioselective Catalytic Intramolecular Cyclopropanation using Modified Cinchona Alkaloid Organocatalysts C.C.C. Johansson, N. Bremeyer, S.V. Ley, D.R. Owen, S.C. Smith and M.J. Gaunt, Angew. Chem., Int. Ed. 2006, 45, 6024-6028.

598. Hydrogenation of Aromatic Ketones, Aldehydes and Epoxides with Hydrogen and Pd(0) EnCatTM 30NP R.H. Perni, S.V. Ley, A.J.P. Steward-Liddon, D. Pears and K. Treacher, Beilstein J. Org. Chem. 2006, 2, 15.

597. A Highly Selective, Organocatalytic Route to Chiral 1,2-Oxazines from Ketones S. Kumarn, D.M. Shaw and S.V. Ley, J. Chem. Soc., Chem. Commun. 2006, 3211-3213.

596. The Use of Polymer Supported Reagents and Scavengers in the Synthesis of Natural Products S.V. Ley, I.R. Baxendale and R.M. Myers, in “Combinatorial Synthesis of Natural Product-Based Libraries”, Ed. A.M. Boldi, CRC Press, Boca-Raton, Florida, USA, 2006. ISBN 0-8493-4000-4. Ch. 6; 131-163.

595. A Flow Process for the Multi-Step Synthesis of the Alkaloid Natural Product Oxomaritidine: A New Paradigm for Molecular Assembly I.R. Baxendale, J. Deeley, C.M. Griffiths-Jones, S.V. Ley, S. Saaby and G. Tranmer, J. Chem. Soc., Chem. Commun. 2006, 2566-2568.

594. Targeting C-Reactive Protein for the Treatment of Human Cardiovascular Disease M.B. Pepys, G.M. Hirschfield, G.A. Tennent, J.R. Gallimore, M.C. Kahan, V. Bellotti, P.N. Hawkins, R.M. Myers, M.D. Smith, A. Polara, A.J.A. Cobb, S.V. Ley, J.A. Aquillina, C.V. Robinson, I. Sharif, G.A. Gray, C.A. Sabin, M.C. Jenvey, S.E. Kolstoe, D. Thompson and S.P. Wood, Nature 2006, 440, 1217-1221.

593. Microwave Assisted Suzuki Coupling Reactions with an Encapsulated Palladium Catalyst for Batch and Continuous Flow Transformations I.R. Baxendale, C.M. Griffiths-Jones, S.V. Ley and G. Tranmer, Chem. Eur. J. 2006, 12, 4407-4416.

592. An Efficient, Asymmetric Organocatalyst-mediated Conjugate Addition of Nitroalkanes to Unsaturated Cyclic and Acyclic Systems C.E.T. Mitchell, S.E. Brenner, J. Garcia-Fortanet and S.V. Ley, Org. Biomol. Chem. 2006, 4, 2039-2049.

591. Chemical Variation of Natural Product-Like Scaffolds: Design and Synthesis of Spiroketal Derivatives G. Zinzalla, L-G. Milroy and S.V. Ley, Org. Biomol. Chem. 2006, 4, 1977-2002.

590. A Highly Enantioselective Total Synthesis of (+)-Goniodiol E.W. Tate, D.J. Dixon and S.V. Ley, Org. Biomol. Chem. 2006, 4, 1698-1706.

589. Diastereoselective Aldol Reactions with Butane 2,3-diacetal Protected Glyceraldehyde Derivatives K. Rahbek Knudsen, A.F. Stepan, P. Michel and S.V. Ley, Org. Biomol. Chem. 2006, 4, 1471-1473.

588. The Use of Polymer-Assisted Solution-Phase Synthesis and Automation for High Throughput Preparation of Biologically Active Materials S.V. Ley, M. Ladlow and E. Vickerstaffe, “Exploring Chemical Diversity for Drug Discovery”, Ed. P.A. Bartlett and M. Entzeroth, Royal Society of Chemistry, UK, 2006. ISBN-10:0-85404-842-1, p3-32.

587. Double Conjugate Addition of Dithiols to Propargylic Carbonyl Systems to Generate Protected 1,3-Dicarbonyl Compounds H.F. Sneddon, A. van den Heuvel, D.M. Shaw, M.J. Gaunt, A. Hirsh, R. Booth and S.V. Ley, J. Org. Chem. 2006, 71, 2715-2725.

586. Practical Synthesis of (S)-Pyrrolidin-2-yl-1H-tetrazole, Incorporating Efficient Protecting Group Removal by Flow-reactor Hydrogenolysis V. Franckevicius, K.R. Knudsen, M. Ladlow, D.A. Longbottom and S.V. Ley, Synlett, 2006, 889-892.

585. Preparation of the Neolignan Natural Product Grossamide by a Continuous Flow Process I.R. Baxendale, C.M. Griffiths-Jones, S.V. Ley and G.K. Tranmer, Synlett 2006, 427-430.

584. Asymmetric Organocatalytic Conjugate Addition of Malonates to Enones Using a Proline Tetrazole C.E.T. Mitchell, K.R. Knudsen, C.E.T. Mitchell and S.V. Ley, J. Chem. Soc. Chem. Commum. 2006, 66-68.

583. Evolution or Revolution: The Challenge to Today’s Medicinal Chemist S.V. Ley and R.M. Myers, “The Chemical Theatre of Biological Systems”, Martin G. Hicks and Carsten Kettner (Eds.), Proceedings of the Beilstein-Institut Workshop, May24th-28th 2004, Bozen, Italy. ISBN 3-8325-1019-2. Pages 1-31.

582. Synthesis of the Alkaloid Natural Products (+)-Plicane and (–)-Obliquine using Polymer Supported Reagents and Scavengers I.R. Baxendale and S.V. Ley, Ind. Eng. Chem. Res., 2005, 44, 8588-8592.

581. Total Synthesis of Two Novel Subpicomolar Sarco/Endoplasmic Reticulum Ca2+ ATPase (SERCA) Inhibitors Designed by an Analysis of the Binding Site of Thapsigargin H. Søhoel, T. Liljefors, S.V. Ley, S.F. Oliver, A. Antonello, M.D. Smith, C.E.Olsen, J.T. Isaacs, S.B. Christensen, J. Med. Chem., 2005, 48, 7005-7011.

580. Michael, Michael-Aldol and Michael-Michael Reactions of Enolate Equivalents of Butane-2,3-diacetal Protected Glycolic Acid Derivatives S.V. Ley, D.J. Dixon, R.T. Guy, F. Rodriguez, and T.D. Sheppard, Org. Biomol. Chem. 2005, 3, 4095-4107.

579. A Versatile Organocatalyst for the Asymmetric Conjugate Addition of Nitroalkanes to Enones C.E.T. Mitchell, S.E. Brenner and S.V. Ley, J. Chem. Soc. Chem Commun., 2005, 5346-5548.

578. A Highly Selective, Organocatalytic Route to Chiral Dihydro-1,2-oxazines S. Kumarn, D.M. Shaw, D.A. Longbottom and S.V. Ley, Org. Lett., 2005, 7, 4189-4191.

577. Synthesis of Alkaloid Natural Products using Solid-Supported Reagents and Scavengers I.R. Baxendale and S.V. Ley, Curr. Org. Chem., 2005, 9, 1521-1534.

576. Non-Metal Catalysed Intramolecular Alkyne Cyclotrimerization Reactions Promoted by Focussed Microwave Heating in Batch and Flow Modes S. Saaby, I.R. Baxendale and S.V. Ley, Org. Biomol. Chem. 2005, 3, 3365-3368.

575. Total Synthesis of Spongistatin I: A New Synthetic Strategy Exploiting its Latent Pseudo Symmetry M. Ball, M.J. Gaunt, D.F. Hook, A.S. Jessiman, S. Kawahara, P. Orsini, A. Scolaro, A.C. Talbot, H.R. Tanner, S. Yamanoi and S.V. Ley, Angew. Chem. Int. Ed., 2005, 44, 5433-5438.

574. A Phase-Switch Purification Approach for the Expedient Removal of Tagged Reagents and Scavengers Following their Application in Organic Synthesis J. Siu, I.R. Baxendale, R.A. Lewthwaite and S.V. Ley, Org. Biomol. Chem., 2005, 3, 3140-3160.

573. Synthesis of the EF-Fragment of Spongistatin I S. Kawahara, M.J. Gaunt, A. Scolaro, S. Yamanoi, P. Orsini and S.V. Ley, Synlett., 2005, 2031-2034.

572.Integrating Microwave-Assisted Synthesis and Solid-Supported Reagents I.R. Baxendale, A-L. Lee and S.V. Ley. Microwave-Assisted Organic Synthesis, eds. J.P. Tierney and P. Lidstrom, 2005, Blackwells ISBN 1-4051-1560-2.

571. The use of a Continuous Flow-Reactor Employing a Mixed Hydrogen-Liquid Flow Stream for the Efficient Reduction of Imines to Amines S. Saaby, K.R. Knudsen, M. Ladlow and S.V. Ley, J. Chem. Soc., Chem. Commun., 2005, 2909-2911.

570. The First Lewis Acid Catalysed Allylboronate Additions to Aldehydes Commentary by D.E.A. Brittain and S.V. Ley, Chemtracts, 2005, 17, 620-626.

569. Development of Methods Suitable for Natural Product Synthesis: The Azadiractin Story S.V. Ley, Pure and Appl. Chem., 2005, 77, 1115-1130.

568. Formation of 4-Aminopyrimidines via Trimerization of Nitriles using Focused Microwave Heating I.R. Baxendale and S.V. Ley, J. Combinatorial Chem. 2005, 7, 483-489.

567. A Highly Automated, Polymer-Assisted Strategy for the Preparation of 2-Alkylthiobenzimidazoles and N,N’-Dialkylbenzimidazolin-2-ones E. Vickestaffe, B.H. Warrington, M. Ladlow and S.V. Ley, J. Combinatorial Chem., 2005, 7, 385-397.

566. The Rapid Preparation of 2-Aminosulfonamide-1,3,4-oxadiazoles Using Polymer-Supported Reagents and Microwave Heating I.R. Baxendale, M. Martinelli and S.V. Ley, Tetrahedron 2005, 61, 5323-5349.

565. Copper- and Palladium-Containing Perovskites: Catalysts for the Ullmann and Sonogashira Reactions S. Lohmann, S.P. Andrews, M.J. Burke, M.D. Smith, J.P. Attfield, H. Tanaka, K. Kaneko and S.V. Ley, Synlett., 2005, 1291-1295.

564. Electronic Encyclopaedia of Reagents in Organic Synthesis. Ed. L.A. Paquette. “(S)-5-Pyrrolidin-2-yltetrazole and (R)-5-Pyrrolidin-2-yltetrazole; A.J.A. Cobb, S.V. Ley, D.A. Longbottom and D.M Shaw, DOI: 10.1002/047084289X.rn00615.

563. Total Synthesis of Antascomicin B D.E.A. Brittain, C.M. Griffiths-Jones, M.R. Linder, M.D. Smith, C McCusker, J.S. Barlow, R. Akiyama, K. Yasuda and S.V. Ley, Angew. Chem., Int. Ed., 2005, 44, 2732-2737.

562. Efficient Batch and Continuous Flow Suzuki Cross-Coupling Reactions under Mild Conditions, Catalysed by Polyurea-encapsulated Palladium(II)acetate and Tetra-n-butylammonium Salts C.K.Y. Lee, A.B. Holmes, S.V. Ley, I.F. McConvey, B. Al-Duri, G.A. Leeke, R.C.D. Santos and J.P.K. Seville, J. Chem. Soc., Chem. Commum., 2005, 2175-2177.

561. Heterogeneous or Homogeneous? A Case Study Involving Palladium-Containing Perovskites in the Suzuki Reaction S.P. Andrews, A.F. Stepan, H. Tanaka, K. Kaneko, S.V. Ley and M.D. Smith, Adv. Syn. and Cat., 2005, 347, 647-654.

560. Steroselective Synthesis of (2R,3S,4S,5R)-trans-3,4-dihydroxy-5-(4-fluorophenoxymethyl)-2-(1-N-hydroxyureidyl-3-butyn-4-yl)tetrahydrofuran and (2R,3S,4S,5R)-trans-5-ethynyl-2-(4-fluorophenoxymethyl)-3.4-O-isopropylidene tetrahydrofuran from Mannose Diacetonide G.V.M. Sharma, S. Punna, L. Hymavathi, N.Y. Reddy, P.R. Krishna, M.S. Chorghade and S.V. Ley, Tetrahedron Asymmetry, 2005, 16, 1135-1140.

559. Stereoselective Synthesis of Chiral Tetrahydrofurans with Potent 5-LO Inhibitory Activity G.V.M. Sharma, S. Punna, P.R. Krishna, M.S. Chorghade and S.V. Ley, Tetrahedron Asymmetry, 2005, 16, 1125-1133.

558. Stereoselective Synthesis of Pharmaceutically Relevant Chiral Tetrahydrofurans for (R)- and (S)-Gyceraldehyde Derivatives G.V.M. Sharma, S. Punna, T.R. Prashad, P.R. Krishna, M.S. Chorghade and S.V. Ley, Tetrahedron Asymmetry, 2005, 16, 1113-1123.

557. Stereoselective Synthesis of (2S, 7S)-7-(4-phenoxymethyl)-2-(1-N-Hydroxyureidyl-3-butyn-4-yl)oxepane: A Potential Anti-Asthmatic Drug Candidate M.K. Gurjar, B.V. Rao, L.M. Krishna, M.S. Chorghade and S.V. Ley, Tetrahedron Asymmetry, 2005, 16, 935-939.

556. Highly Diastereoselective Desymmetrisation of Cyclic meso-Anhydrides and Derivatisation to Mono-Protected 1,4-Diols A.C. Evans, D.A. Longbottom, M. Matsuoka and S.V. Ley, Synlett., 2005, 646-648.

555. A Homo-Proline Tetrazole as an improved Organocatalyst for the Asymmetric Michael Addition of Carbonyl Compound to Nitro-Olefins C.E.T. Mitchell, A.J.A. Cobb and S.V. Ley, Synlett, 2005, 611-614.

554. Synthesis of a Ceramide Sphingolipid as a Potential Sex Pheromone of the Hair Crab Erimacrus isembeckii using Butane-2,3-diacetal Desymmetrised Glycolic Acid Building Blocks D.J. Dixon, S.V. Ley, S. Lohmann and T.D. Sheppard, Synlett., 2005, 481-484.

553. Organic Chemistry in Ionic Liquids using Non-Thermal Energy Transfer Processes J. Habermann, S. Ponzi and S.V. Ley, Mini Reviews in Org. Chem., 2005, 2, 125-137.

552. The Total Synthesis of the Annonaceous Acetogenin, 10-Hydroxyasimicin G.L. Nattrass, E. Diez, M. McLachlan, D.J. Dixon and S.V. Ley, Angew. Chem. Int. Ed., 2005, 44, 580-584.

551. Total Synthesis of the Fusarium Toxin Equisetin L.T. Burke, D.J. Dixon, S.V. Ley and F. Rodríguez, Org. Biomol. Chem., 2005, 3, 274-280.

550. Organocatalysis with Proline Derivatives: Improved Cataysts for the Asymmetric Mannich, Nitro- Michael and Aldol Reactions A.J. Cobb, D.M. Shaw, D.A. Longbottom, J.B. Gold and S.V. Ley, Org. Biomol. Chem., 2005, 3, 84-96.

549. The 1702 Chair of Chemistry at Cambridge: Transformation and Change Eds. M. Archer and C. Haley, Chemistry in a Changing World: New Tools for the Modern Molecule Maker, S.V. Ley, Cambridge University Press, 2005, Ch. 12, 283-303.  ISBN 0 521 82873 2

548. In Honour of Professor Leo A. Paquette S.V. Ley, Heterocycles, 2004, 62, 1-3.

547. Studies on the Generation of Enolate Anions from Butane-2,3-diacetal Protected Glycolic Acid Derivatives and Subsequent Highly Diastereoselective Coupling Reactions with Aldehydes and Acid Chlorides S.V. Ley, D.J. Dixon, R.T. Guy, M.A. Palomero A. Polara, F. Rodriguez and T.D. Sheppard, Org. Biomol. Chem., 2004, 2, 3618-3627.

546. Preparation of Enantiopure Butane-2,3-diacetals of Glycolic Acid and Alkylation Reactions leading to α-Hydroxyacid and Amide Derivatives S.V. Ley, E. Diez, D.J. Dixon, R.T. Guy, P. Michel and T.D. Sheppard, Org. Biomol. Chem., 2004, 2, 3608-3617.

545. Evolving Cascades: The Claisen Rearrangement in the Development of Tandem Sequences of Three or More Reactions Commentary by B.L. Gray and S.V. Ley, Chemtracts, 2004, 235-241.

544. Enantioselective Organocatalytic Cyclopropanation with Ammonium Ylides C.D. Papageorgiou, M.A. Cubillo de Dios, S.V. Ley and M.J. Gaunt, Angew. Chem. Int. Ed., 2004, 43, 4641-4644.

543. A Concise Total Synthesis of (+) Okaramine C, E. Cleator, P.R. Hewitt and S.V. Ley, Org. Biomol. Chem., 2004, 2, 2415-2417.

542. Synthesis of the Thapsigargins S.V. Ley, A. Antonello, E.P. Balskus, D.T. Booth, S.B. Christensen, E. Cleator, H. Gold, K. Högenauer, U. Hünger, R.M. Myers, S.F. Oliver, O. Simic, M.D. Smith, H. Søhoel, and A.J.A. Woolford Proc. Nat. Acad. Sci., 2004, 101, 12073-12078.

541. 5-Pyrrolidin-2-yltetrazole as an Asymmetric Organocatalyst for the Addition of Ketone to Nitro-Olefins A.J. Cobb, D.A. Longbottom, D.M. Shaw and S.V. Ley, J. Chem. Soc. Chem. Commum., 2004, 1808-1809.

540. The Preparation and Alkylation of a Butanedione-Derived Chiral Glycine Equivalent and its use for the Synthesis of alpha-Amino Acids and alpha, alpha-Disubstituted Amino Acids C.I. Harding, D.J. Dixon and S.V. Ley, Tetrahedron, 2004, 60, 7679-7692.

539. Development of an Indole Safety-Catch Linker for use in Analytical Constructs J.J. Scicinski, M.S. Congreve and S.V. Ley, J. Combinatorial Chem., 2004, 6, 375-384.

538. Fully Automated Polymer-Assisted Synthesis of 1,5-Biaryl Pyrazoles E. Vickerstaff, B.H. Warrington, M. Ladlow and S.V. Ley, J. Combinatorial Chem., 2004, 6, 332-339.

537.An Intramolecular Organocatalytic Cyclopropanation Reaction N. Breymer, S.C. Smith, S.V. Ley and M.J. Gaunt, Angew. Chem. Int. Ed., 2004, 43, 2681-2684.

536. Multi-step Application of Immobilized Reagents and Scavengers: A Total Synthesis of Epothilone C R.I. Storer, T. Takemoto, P.S. Jackson, D.S. Brown, I.R. Baxendale and S.V. Ley, Chem. Eur. J., 2004, 10, 2529-2547.

535. Anomeric Oxygen to Carbon Rearrangement of Alkynyl Tributylstannane Derivatives of Furanyl (γ)- and Pyranyl (δ)-Lactols M.F. Buffet, D.J. Dixon, S.V. Ley, D.J. Reynolds and R.I. Storer, Org. Biomol. Chem., 2004, 2, 1145-1154.

534. Grignard Additions to 2-Uloses: Synthesis of Stereochemically Pure Tertiary Alcohols E. Cleator, C.F. McCusker, F. Stelzer and S.V. Ley, Tetrahedron Lett., 2004, 45, 3077-3080.

533. Catalytic polymer-supported potassium thiophenolate in methanol for the removal of ester, amide and thioacetate protecting groups R.N. MacCoss, D.J. Henry, C. T. Brain, S.V. Ley, Synlett 2004, 675-678.

532. Polymer-Assisted Multistep Solution Phase Synthesis and Biological Screening of Histone Deacetylase Inhibitors A. Bapna, M. Ladlow, E. Vickerstaff, B.H. Warrington, T-P. Fan and S.V. Ley, Org. Biomol. Chem., 2004, 2, 611-620.

531. 5-Pyrrolidin-2-yltetrazole: A New, Catalytic, More Soluble Alternative to Proline in an Organocatalytic Asymmetric Mannich-type Reaction A.J.A. Cobb, D.M. Shaw and S.V. Ley, Synlett., 2004, 558-560.

530. Microwave Assisted Leimgruber-Batcho Reaction for the preparation of Indoles, Azaindoles and Pyrroylquinolines J. Siu, I.R. Baxendale and S.V. Ley, Org. Biomol. Chem., 2004, 2, 160-167.

529. The Synthesis of (-)-Gloeosporone, a Potent Fungal Autoinhibitor of Spore Germination using a pi-Allytricabonyl iron Lactone Complex and a New Reductive Decomplexation Procedure for the Installation of the Embedded 1,7-Diol Component of the Natural Product E. Cleator, J. Harter and S.V. Ley, Heterocycles, 2004, 62, 619-633.

528. Preparation of Butane-1,2-diacetal Protected L-Glyceraldehyde from D-Mannitol S.V. Ley and P. Michel, Synthesis, 2004, 147-150.

527. Copper(I)-Catalysed Preparation of (E)-3-Iodoprop-2-enoic Acid D.J. Dixon, S.V. Ley and D.A. Longbottom, Org. Syn., 2003, 80, 129-132.

526. Therapeutic Inhibition of C-Reactive Protein – Novel Drugs, Novel Mechanisms G.M. Hirschfield, M.D. Smith, S.V. Ley, S. Kolstoe, D. Thompson, S.P. Wood and M.B. Pepys, Clinical Sci., 2003, 104 (Suppl. 49) 65-66.

525. Enantioselective Synthesis of the Tetrahydrobenzylisoquinoline Alkaloid (-)-Norarmepavine using Polymer-Supported Reagents I.R. Baxendale, T.D. Davidson S.V. Ley and R.H. Perni, Heterocycles, 2003, 60, 2707-2715.

524. A Route to the Thapsigargins from (S)-Carvone Providing a Substrate-Controlled Total Synthesis of Trilobolide, Nortrilobolide and Thapsivillosin F S.F. Oliver, K. Hoegenauer, O. Simic, A. Antonello, M.D. Smith and S.V. Ley, Angew. Chem., Int. Ed., 2003, 42, 5996-6000.

523. Synthesis of the C-1-C-28 ABCD Unit of Spongistatin 1 M. J. Gaunt, A. Jessiman, P. Orsini and S.V. Ley, Org. Lett., 2003, 4819-4822.

522. A Practical and Efficient Synthesis of the C-16 to C-28 Spiroketal Fragment (CD) of the Spongistatins M.J. Gaunt, D.F. Hook and S.V. Ley, Org. Lett., 2003, 5, 4815-4818.

521. Development of New Synthetic Tools for the Preparation of Biologically Active Molecules S.V. Ley, I.R. Baxendale and P.Grice, NATO/FEBS International Summer School, Spetses, Greece, “Chemical Probes in Biology”, M. Schneider ed., Kluwer Academic Publishers, Netherlands, p 235-244.

520. The Use of Butane Diacetals of Glycolic Acid as Precursors for the Synthesis of the Phytotoxic Camodulin Inhibitor Herbarumin II E. Diez, D.J. Dixon, S.V. Ley, A. Polara and F. Rodríguez, Helv.Chim. Acta., 2003, 86, 3717-3729.

519. Recyclable Polyurea-Microencapsulated Pd(0) Nanoparticles: An Efficient Catalyst for the Hydrogenolysis of Epoxides C. Mitchell, D. Pears, S.V. Ley, J-Q. Yu and W. Zhou, Org. Lett., 2003, 5, 4665.

518. A Convenient Route to Enantiomerically Pure 2-Substituted Methyl Glycerate Derivatives S.V. Ley, P. Michel and C. Trapella, Org. Lett., 2003, 5, 4553.

517. Modern Synthetic Methods for Copper-Mediated C(Aryl)-O,C (Aryl)-N and C(Aryl)-S Bond Formation S.V. Ley and A. W. Thomas, Angew. Chem. Int. Edn., 2003, 42, 5400.

516. The Synthesis of the Anti-Malarial Natural Product Polysphorin and Analogues using Polymer-Supported Reagents and Scavengers A-L. Lee and S.V. Ley, Org. Biomol. Chem., 2003, 1, 3957.

515. Palladium-containing Perovskites: Recoverable and Reusable Catalysts for Suzuki Couplings M.D. Smith, C Ramarao, P.E. Brennan, A.F. Stepan and S.V. Ley, J. Chem. Soc., Chem. Commun., 2003, 2652.

514. A Rapid Stereocontrolled Synthesis of the 3a-Hydroxy-pyrrolo[2,3b]indole Skeleton, a Building Block for 10b-Hydroxy-pyrazino[1′,2′:1,5]pyrrolo[2,3-b]indole-1,4-dione S.V. Ley, E. Cleator and P.R. Hewitt, Org. Biomol. Chem., 2003 , 1, 3492.

513. A Sequential Tetra-n-propylammonium Perruthenate-Wittig Oxidation R.N. MacCoss, E.P. Balskus, S.V. Ley, Tetrahedron Lett., 2003, 44, 7779.

512. Synthesis of (-)-Gloeosporone, a Fungal Autoinhibitor of Spore Germination using a π-Allyltricarbonyliron Lactone Complex as a Templating Architecture for 1,7-Diol Construction E. Cleator, J. Harter, C.J. Hollowood and S.V. Ley, Org. Biomol. Chem., 2003, 1, 3263.

511.1,5-Asymmetric Induction of Chirality using π-Allyltricarbonyliron Lactone Complexes: Highly Diastereoselective Synthesis of α-Functionalised Carbonyl Compounds C.J. Hollowood, S.V. Ley, and E.A. Wright, Org. Biomol. Chem., 2003, 1, 3208.

510. Reductive Decomplexation of π-Allyltricarbonyliron Lactone Complexes using Sodium Naphthalenide as a Route to Stereodefined 1,7-diols and 2,3-diene-1,7-diols C.J. Hollowood and S.V. Ley, Org. Biomol. Chem., 2003, 1, 3197.

509. Total Synthesis of the Polyenoyltetramic Acid Polycephalin C D.A. Longbottom, A.J. Morrison, D.J. Dixon and S.V. Ley, Tetrahedron, 2003, 59, 6955.

508. Rhodium-Catalysed Coupling of Heterocycles and Alkenes: A Novel Mechanism of C-H Activation, Commentary by E.P. Balskus and S.V. Ley, Chemtracts, 2003, 443.

507. Synthesis of Enantiomers of Butane-1,2-diacetal-Protected Glyceraldehyde and of (R,R)-Butane-1,2-diacetal-Protected Glycolic Acid P. Michel and S.V. Ley, Synthesis, 2003, 1598.

506. Supported Reagents and Scavengers in Multi-Step Organic Synthesis I.R. Baxendale, R.I. Storer and S.V. Ley in “Polymeric Materials in Organic Synthesis and Catalysis”. Ed. M.R. Buchmeiser VCH Berlin, ISBN. 3-527-30630-7, 2003, 53.

505. Fully Automated Multi-step Solution Phase Synthesis using Polymer Supported Reagents: Preparation of Histone Deacylase Inhibitors E. Vickerstaff, M. Ladlow, S.V. Ley and B. Warrington, Org. Biomol. Chem., 2003, 1, 2419.

504Total Synthesis of the Phytotoxic Agent Herbarumin II using Butane Diacetals of Glycolic Acid as Building Blocks E. Diez, D.J. Dixon, S.V. Ley, A. Polara and F. Rodriguez, Synlett., 2003, 1186.

503. A Total Synthesis of Epothilones using Solid-Supported Reagents and Scavengers R.I. Storer, T. Takemoto, P.S. Jackson and S.V. Ley, Angew. Chem. Int. Edn., 2003, 42, 2321.

502. Synthesis of Carbohydrate Derivatives Using Solid-Phase Work-Up and Scavenging Techniques R.N. MacCoss, P.E. Brennan and S.V. Ley, Org. Biomol. Chem., 2003, 1, 2029.

501. Versatile Solid-Phase Synthesis of Secondary Amines from Alcohols. Development of an N-Boc-(o-nitrobenzene) Sulfonamide Linker M.S. Congreave, C. Kay, J.J. Scicinski, S.V. Ley, G. Williams, P.J. Murray, S.C. McKeown and S.P. Watson, Tetrahedron Lett., 2003, 44, 4153.

500. Use of π-Allyltricarbonyliron Lactone Complexes in the Synthesis of Taurospongin A: A Potent Inhibitor of DNA Polymerase β and HIV Reverse Transcriptase C.J. Hollowood, S.V. Ley and S. Yamanoi, Org. Biomol. Chem., 2003, 1, 1664.

499. Addition of Dithiols to Bis-ynones: Development of a Versatile Platform for the Synthesis of Polyketide Natural Products H.F. Sneddon, M.J. Gaunt and S.V. Ley, Org. Lett., 2003, 5, 1147.

498. Transfer Hydrogenation using Recyclable Polyurea-Encapsulated Palladium: Efficient and Chemoselective Reduction of Aryl Ketones J-Q Yu, H-C. Wu, C. Ramarao, J.B. Spencer and S.V. Ley, J. Chem. Soc., Chem. Commun., 2003, 678.

497. Organic-Catalyst-Mediated Cyclopropanation Reaction C.D. Papageorgiou, S.V. Ley and M.J. Gaunt, Angew. Chem. Int. Edn., 2003, 42, 828.

496. A 2,3-Butanedione Protected Glycine Equivalent: A New Building block for the Stereoselective Synthesis of Enantiopure N-Protected a-Amino Acids D.J. Dixon, C.I. Harding, S.V. Ley and D.M.G. Tilbrook. J. Chem. Soc., Chem. Commun., 2003, 468.

495. Microencapsulation of Osmium Tetroxide in Polyurea S.V. Ley, C. Ramarao, A-L. Lee, N. Østergaard, S.C. Smith and I.M. Shirley, Org. Lett., 2003, 5, 185.

494. Development of β-Keto 1,3-Dithianes as Versatile Intermediates for Organic Synthesis M.J. Gaunt, H.F. Sneddon, P.R. Hewitt, P. Orsini, D.F. Hook and S.V. Ley, Org. Biomol. Chem., 2003, 1, 15.

493. Applications of DiMaS: A New Mass Spectrometry Tagging Strategy to Focussed Peptide Libraries C. Kay, A. Amour, M.I. Bird, O. Heudi, S.V. Ley, P. Marshall, S.C. McKeown and C.L. Smith, “Innovation Perspectives in Solid Phase Synthesis and Combinatorial Chemical Libraries”, Collect. Pap., Int. Symp., 9th ISBN 0-9515735-4-3, 2002, 85.

492. Benzotriazoles in Solid Phase Organic Chemistry Commentary by M. Donghi, J. Habermann and S.V. Ley, Chemtracts, 2002, 751.

491. Sir Derek Harold Richard Barton S.V. Ley and R.M. Myers, Biogr. Mems. Fell. R. Soc. Lond., 2002, 48, 1.

490. Azadirachtin Disrupts Formation of Organised Microtubule Arrays During Microgametogenesis of Plasmodium berghei O. Billker, M.K. Shaw, I.W. Jones, S.V. Ley, A.J. Mordue and R.E. Sinden, J. Eukaryot. Microbiol., 2002, 49, 489.

489. Electronic Encylopaedia of Reagents for Organic Synthesis Ed. L.A. Paquette, J. Wiley, “Polymer Supported Perruthenate”, S.V. Ley and C. Ramarao, DOI: 10.1002/047084289X.rn00029

488. Electronic Encylopaedia of Reagents for Organic Synthesis Ed. L.A. Paquette, J. Wiley, “Polymer Supported Carbonate”, S.V. Ley and R. N. Bream, DOI: 10.1002/047084289X.rn00028

487. Electronic Encylopaedia of Reagents for Organic Synthesis Ed. L.A. Paquette, J. Wiley, “Polymer Supported Hydroxide”, S.V. Ley, I.R. Baxendale and A-L. Lee, DOI: 10.1002/047084289X.rn00058

486. Electronic Encylopaedia of Reagents for Organic Synthesis Ed. L.A. Paquette, J. Wiley, “Polymer Supported Ammonium Periodate”, S.V. Ley and A.J. Hazelwood, DOI: 10.1002/047084289X.rn00030

485. Electronic Encylopaedia of Reagents for Organic Synthesis Ed. L.A. Paquette, J. Wiley, “Polymer Supported Scwhiesinger Base” S.V. Ley and J.J. Scicinski, DOI: 10.1002/047084289X.rn00026

484. Electronic Encylopaedia of Reagents for Organic Synthesis Ed. L.A. Paquette, J. Wiley, “Polymer Supported Borohydride Exchange Resin”, S.V. Ley and R.I. Storer, DOI: 10.1002/047084289X.rn00027

483. Electronic Encylopaedia of Reagents for Organic Synthesis Ed. L.A. Paquette, J. Wiley, “Polymer Supported Acid”, S.V. Ley and A. Horvath, DOI: 10/1002/047084289X.rn00059.pub2

482. Electronic Encylopaedia of Reagents for Organic Synthesis Ed. L.A. Paquette, J. Wiley, “Polymer Supported Thiophenol”, S.V. Ley, D.J. Henry and M. Matsuoka, DOI: 10.1002/047084289X.rn00031

481. Application of ReactArray Robotics and Design of Experiment Techniques in Optimisation of Supported Reagent Chemistry C. Jamieson, M.S. Congreave, D.F. Emiabata-Smith, S.V. Ley and J.J. Scicinski, Org. Proc. Res. Dev., 2002, 6, 823.

480. Organic Synthesis in a Changing World S.V. Ley and I.R. Baxendale, Chem. Record, 2002, 2, 377.

479. Total Synthesis of the Cyclic Peptide Argyrine B S.V. Ley and A. Priour, Eur. J. Org. Chem., 2002, 3995.

478. A Mild, Enantioselective Synthesis of (R)-Salmeterol via Sodium Borohydride, Calcium Chloride Asymmetric Reduction of a Phenacyl Phenylglycinol Derivative R.N. Bream, S.V. Ley, B. McDermott and P.A. Procopiou, J. Chem. Soc., Perkin Trans. 1, 2002, 2237.

477. Highly Selective Entry to the Azadirachtin Skeleton via a Claisen Rearrangement/Radical Cyclization Sequence T. Duran-Reville, L.A. Gobbi, B.L. Gray, S.V. Ley, and J.S. Scott, Org. Lett., 2002, 4, 3847.

476. Synthesis of the β2 Agonist (R)-Salmeterol using a Sequence of Supported Reagents and Scavenging Agents R.N. Bream, S.V. Ley and P.A. Procopiou, Org. Lett., 2002, 4, 3793.

475. Palladium Acetate in Polyurea Microcapsules: A Recoverable and Reversible Catalyst for Hydrogenations N. Bremeyer, S.V. Ley, C. Ramarao, I.M. Shirley and S.C. Smith, Synlett, 2002, 1843.

474. Butane-2,3-Diacetals of Glyceraldehyde: A New, Stable Alternative to Glyceraldehyde Acetonide P. Michel and S.V. Ley, Angew. Chem. Int. Edn., 2002, 41, 3898.

473. Highly Diastereoselective Ketone Aldol Reactions of Butane-2,3-diacetal Desymmetrized Glycolic Acid D.J. Dixon, A. Guarna, S.V. Ley, A. Polara and F. Rodríguez, Synthesis, 2002, 1973.

472. Application of Polymer-Supported Enzymes and Reagents in the Synthesis of γ–Aminobutyric Acid GABA AnaloguesI.R. Baxendale, M. Ernst, W-R. Krahnert and S.V. Ley, Synlett, 2002, 1641.

471. Analytical Techniques for Small Molecule Solid Phase Synthesis J.J. Scicinski, M.S. Congreve, C. Kay and S.V. Ley, Curr. Med. Chem., 2002, 9, 2103.

470. Synthesis, Structure Revision and Absolute Configuration of Didemniserinolipid B, a Serinol Marine Natural Product from a Tunicate Didemnum sp., H. Kiyota, D.J. Dixon, C.K. Luscombe, S. Hettstedt and S.V. Ley, Org. Lett., 2002, 4, 3223.

469. Reductive Decomplexation of p-Allyltricarbonyliron Lactone Complexes: A New Route to Stereo-defined 1,7-Diols and 2,3-Diene-1,7-diols S.V. Ley and C.J. Hollowood, J. Chem. Soc., Chem. Commun., 2002, 2130.

468. Total Synthesis of the Amaryllidacea Alkaloid (+)-Plicamine using Solid-Supported Reagents I.R. Baxendale, S.V. Ley, C. Piutti and M. Nesi, Tetrahedron, 2002, 58, 6285.

467. Total Synthesis of Polycephalin C and Determination of the Absolute Configurations at the 3”, 4” Ring Junction D.A. Longbottom, A.J. Morrison, D.J. Dixon and S.V. Ley, Angew. Chem., Int. Edn., 2002, 41, 2786.

466. A Concise Synthesis of Carpanone using Solid-Supported Reagents and Scavengers I.R. Baxendale, A-L. Lee and S.V. Ley, J. Chem. Soc., Perkin Trans. 1, 2002, 1850.

465.  A Polymer Supported [1,3,2] Oxazapholidine for the Conversion of Isothiocyanates to Isocyanides and their Subsequent Use in an Ugi Reaction  S.V. Ley and S.J. Taylor, Bioorg. Med. Chem. Lett., 2002, 12, 1813.

464. Synthesis of Taurospongin A: A Potent Inhibitor of DNA Polymerase and HIV Reverse Transcriptase using p-Allyltricarbonyliron Lactone Complexes C.J. Hollowood, S.V. Ley and S.Yamanoi, J. Chem. Soc., Chem. Commun., 2002, 1624.

463. New Tools and Concepts in Modern Organic Synthesis S.V. Ley and I.R. Baxendale, Nature Reviews, 2002, 1, 573.

462. Total Synthesis of the Amaryllidaceae Alkaloid (+)-Plicamine and its Unnatural Enantiomer by using Solid-Supported Reagents and Scaveners in a Multistep sequence of Reactions I.R. Baxendale, S.V. Ley and C. Piutti, Angew. Chem. Int. Edn., 2002, 41, 2194.

461. Polyurea-Encapsulated Palladium (II) Acetate: A Robust and Recyclable Catalyst for use in Conventional and Supercritical Media S.V. Ley, C. Ramarao, R.S. Gordon, A.B. Holmes, A.J. Morrison, I.F. McConvey, I.M. Shirley, S.C. Smith and M.D. Smith, J. Chem. Soc., Chem. Commun., 2002, 1134.

460. Encapsulation of Palladium in Polyurea Microcapsules C. Ramarao, S.V. Ley, S.C. Smith, I.M. Shiley and N. DeAlmeida, J. Chem. Soc., Chem. Commun., 2002, 1132.

459. A Clean Conversion of Aldehydes to Nitriles using a Solid-Supported Hydrazine I.R. Baxendale, S.V. Ley and H.P. Sneddon, Synlett, 2002, 775.

458. Solid-Supported Reagents for Multi-Step Organic Synthesis: Preparation and Application S.V. Ley, I.R. Baxendale, G. Brusotti, M. Caldarelli, A. Massi and M. Nesi, Il Farmaco, 2002, 57, 321.

457. The Total Synthesis of the Annonaceous Acetogenin Muricatetrocin C, D.J. Dixon, S.V. Ley, D.J. Reynolds, Chem. Eur. J., 2002, 8, 1621.

456. Analytical Construct Resins for Analysis of Solid Phase Chemistry M.S. Congreve, S.V. Ley and J.J., Scicinski, Chem. Eur. J., 2002, 8, 1768.

455. The Simultaneous Use of Immobilised Reagents for the One-Pot Conversion of Alcohols to Carboxylic Acids K. Yasuda and S.V. Ley, J. Chem. Soc., Perkin Trans. 1, 2002,1024.

454. The Use of π-Allyltricarbonyliron Lactone Complexes in the Synthesis of the Resorcyclic Macrolides and Zearalenol S. Burckhardt and S.V. Ley, J. Chem. Soc., Perkin Trans. 1, 2002, 874.

453. Total Synthesis of the Cyclic Heptapeptide Argyrin B: A New Potent Inhibitor of T-Cell Independent Antibody Formation S.V. Ley, A. Priour and C. Heusser, Org. Lett., 2002, 4, 711.

452. Synthesis of Trifluoromethyl Ketones using Polymer Supported Reagents I.R. Baxendale, S.V. Ley, W. Lumeras and M. Nesi, Combinatorial Chem. and High Throughput Screening, 2002, 5, 145.

451. A Polymer-Supported Iridium Catalyst for the Stereoselective Isomerisation of Double Bonds I.R. Baxendale, A-L Lee and S.V. Ley, Synlett, 2002, 516.

450. The Effects of Phytochemical Pesticides on the Growth of Cultured Invertebrate and Vertebrate Cells A. Salehzadeh, A. Jabbar, L. Jennens, S.V. Ley, R.S. Annadurai, R. Adams and R.H.C. Strong, Pest. Manag. Sci., 2002, 58, 268.

449. Synthesis of Nornicotine, Nicotine and Other Functionalised Derivatives Using Solid-Supported Reagents and Scavengers I.R. Baxendale, G. Brusotti, M. Matsuoka and S.V. Ley, J. Chem. Soc., Perkin Trans. 1, 2002, 143.

448. Tritiated Dihydroazadiractin Binding to Schistocerca Gregaria Testes and Spodoptera Sf9 Cells Suggests a Similar Cellular Mechanism of Action for Azadirachtin A.J. Mordue, A.J. Nisbet, Lyn Jennens, S.V. Ley, and W. Mordue, 1999 Azadirachta indica A. Juss. Int. Neem Conference, Gatton, Australia. Eds R.P. Singh and R.C. Saxena, Oxford and IBH Publ. Co PVT. Ltd, Chapter 22, 247-256.

447. Consecutive Three- and Four-Component Coupling Reactions with Anions Generated from a Butane Diacetal Desymmetrized Glycolic Acid Derivative D.J. Dixon, S.V. Ley and F. Rodríguez, Angew. Chem. Int. Edn., 2001, 40, 4763.

446. The Total Synthesis of (+)-Aspicilin using 2,3-Butane Diacetal Protected Butane Tetrols via a Chiral Memory Protocol D.J. Dixon, A.C. Foster and S.V. Ley, Can. J. Chem., 2001, 79, 1668.

445. A Short and Efficient Stereoselective Synthesis of the Potent 5-Lipoxygenase Inhibitor CMI-977 D.J. Dixon, S.V. Ley, D.J. Reynolds and M.S. Chorghade, Ind. J. Chem., 2001, 39, 1043.

444. Highly Diastereoselective Michael Addition Reactions of Butane-2,3-diacetal Desymmetrized Glycolic Acid. Preparation of α-Hydroxy-γ-amino Acid Derviatives D.J. Dixon, S.V. Ley and F. Rodríguez, Org. Lett., 2001, 3, 3753.

443. Highly Diastereoselective Lithium Enolate Aldol Reactions of Butane-2,3-diacetal Desymmetrized Glycolic Acid and Deprotection to Enantiopure anti-2,3-Dihydroxy Esters D.J. Dixon, S.V. Ley, A. Polara and T. Sheppard, Org. Lett., 2001, 3, 3749.

442. A New Route to Butane -1,2-Diacetals and the Development of Alternative Substitution Patterns to Facilitate Differential Protection of the Products S.V. Ley and P. Michel, Synlett, 2001, 1793.

441. (–)-(4S)-1-Chloro-3-(2,2-dimethyl-1,3-dioxolan-4-yl)-propan-2-one Structure Reports Online J.E. Davies, D.F. Hook and S.V. Ley, Acta Cryst. Section E, 2001, 1098.

440. Tetra-N-Propylammonium Perruthenate: A Case Study in Catalyst Recovery and Reuse Involving Tetraalkylammonium Salts S.V. Ley, C. Ramarao and M.D. Smith, J. Chem. Soc., Chem. Commun., 2001, 2278.

439. Rapid Assembly of Anti-Anto-1,2,3-Triol Motifs via Stereoselective Addition of Organometallics to Aldehydes Obtained from (R’,R’,S,R)-2,3-Butane Diacetal Protected Butane Tetraol Derivatives D.J. Dixon, L. Krause and S.V. Ley, J. Chem. Soc., Perkin Trans. 1, 2001, 2516.

438. Solid-Supported Reagents for the Oxidation of Aldehydes to Carboxylic Acids T. Takemoto, K. Yasuda and S.V. Ley, Synlett, 2001, 1555.

437. The Bestmann Ylide as a Multi-Purpose Wittig Reagent Commentary by J. Habermann and S.V. Ley, Chemtracts, 2001, 386.

436. A Concise Synthesis of the Natural Product Carpanone using Solid-Supported Reagents and Scavengers I.R. Baxendale, A.-L. Lee and S.V. Ley, Synlett, 2001, 1482.

435. Both Mosquito-Derived Xanthurenic Acid and a Host Blood-Derived Factor Regulate Gamentogenesis of Plasmodium in the Mid-Gut of the Mosquito M. Arai, O. Billker, H.R. Morris, M. Panico, M. Delcroix, D.J. Dixon, S.V. Ley and R. E. Sinden, Mol. Biochem. Parasitol., 2001, 116, 17.

434. Butane-2,3-diacetal Desymmetrised Glycolic Acid – A New Building Block for the Stereoselective Synthesis of Enantiopure α-Hydroxy Acids E. Diez, D.J. Dixon and S.V. Ley, Angew. Chem. Int. Ed. Engl., 2001, 40, 2906.

433. New Polyethylene Glycol Polymers as Ketal Protecting Groups: A Polymer Supported Approach to Symmetrically Substituted Spiroketals R. Haag, A.G. Leach, S.V. Ley, M. Nettekoven, J. Schnaubelt, Syn. Commun., 2001, 31, 79.

432. Development and Application of a Carbonyl-13C Enriched BAL Linker for Solid Phase Reaction Monitoring C. Jamieson, M.S. Congreve, P.R. Hewitt, J.J. Scicinski and S.V. Ley, J. Combinatorial Chem., 2001, 3, 397.

431. Solid-Phase Development of a 1-Hydroxybenzotriazole Linker for Heterocycle Synthesis using Analytical Constructs J.J. Scicinski, M.C. Congreave, C. Jamieson, S.V. Ley, E.S. Newman, V.M. Vinader and R.A.E. Carr, J. Combinatorial Chem, 2001, 3, 387.

430. The Development and Application of Supported Reagents for Multi-step Organic Synthesis S.V. Ley and I.R. Baxendale in ‘Supported Catalysts and their Applications’, Ed. D.C. Sherrington and A.P. Kybett, The Royal Society of Chemistry Proceedings, 2001, 9.

429. New Catalyst for Olefin Metathesis Commentary by P.E. Brennan and S.V. Ley, Chemtracts, 2001, 88.

428. A New Phase-Switch Method for Application in Organic Synthesis Programs Employing Immobilization through Metal-Chelated Tagging S.V. Ley, A. Massi, F. Rodríguez, D.C. Horwell, R.A. Lewthwaite, M.C. Pritchard and A.M. Reid, Angew. Chem. Int. Ed., 2001, 40, 1053.

427. A Polymer-Supported Thiolating Agent S.V. Ley, A.G. Leach and R.I. Storer, J. Chem. Soc., Perkin Trans. 1, 2001, 358.

426. 1,2- Diacetals: A New Opportunity for Organic Synthesis S.V. Ley, D.K. Baeschlin, D.J. Dixon, A.C. Foster, S.J. Ince, H.W.M. Priepke and D.J. Reynolds, Chem. Rev., 2001, 101, 53.

425. Solid Phase Reaction Monitoring-Chemical Derivatisation and Off-Bead Analysis C. Kay, O.E. Lorthior, N.J. Parr, M. Congreve, S.C. McKeown, J.J. Scicinski and S.V. Ley, Analytical Methods for Combinatorial Chemistry, Biotechnol. Bioeng., 2000, 71, 110.

424. Multistep Organic Synthesis using Solid Supported Reagents and Scavengers: A New Paradigm in Chemical Library Generation S.V. Ley, I.R. Baxendale, R.N. Bream, P.S. Jackson, A.G. Leach, D.A. Longbottom, M. Nesi, J.S. Scott, R.I. Storer and S.J. Taylor, J. Chem. Soc., Perkin Trans. 1, 2000, 3815.

423. Deracemization of Baylis-Hillman Adducts Commentary by S.V. Ley and F. Rodríguez, Chemtracts, 2000, 596.

422. New Strategies for Organic Synthesis: The First Highly Enantioselective Organocatalytic Diels-Alder Reaction Commentary by E. Diez and S.V. Ley, Chemtracts, 2000, 592.

421. A Short Stereoselective Total Synthesis of the Fusarium Toxin Equisetin L. T. Burke, D.J. Dixon, S.V. Ley and F. Rodríguez, Org. Lett., 2000, 2, 3611.

420. A Rapid Approach for the Optimisation of Polymer Supported Reagents in Synthesis C. Jamieson, M.S. Congreave, D.F. Emiabata-Smith and S.V. Ley, Synlett, 2000, 1603.

419. The Total Synthesis of the Annonaceous Acetogenin Muricatetrocin C, D.J. Dixon, S.V. Ley and D. J. Reynolds, Angew. Chem., Int. Ed., 2000, 39, 3622.

418. Parallel Solution-phase synthesis of Functionalised Bicyclo [2.2.2]octanes: Generation of a Library using Orchestrated Multi-Step Sequences of Polymer Supported Reagents and Sequesterants S.V. Ley and A. Massi, J. Chem. Soc., Perkin Trans. 1, 2000, 3645.

417. Chemoenzymatic Synthesis of L-Galactosylated Dimeric Sialyl Lewis Structures Employing a-1,3-Fucosyltransferase V, A. Düffels, L.G. Green, R. Lenz, S.V. Ley, S. P. Vincent and C-H. Wong, Bioorg. Med. Chem., 2000, 8, 2519.

416. Combined Application of Analytical Techniques for the Characterisation of Polymer Supported Species P. Grice, A.G. Leach, S.V. Ley, A. Massi and D.M. Mynett, J. Combinatorial Chem., 2000, 2, 419.

415. The Use of π-Allyltricarbonyliron Lactone Complexes in the Synthesis of the Resorcylic Macrolides α- and β- Zearalenol S.V. Ley and S. Burckhardt, J. Chem. Soc., Perkin Trans. 1, 2000, 3028.

414. Polymer-Supported Reagents in Multi-Step Organic Synthesis: Application to the Synthesis of Sildenafil I.R. Baxendale and S.V. Ley, Bioorg. Med. Chem. Lett., 2000, 10, 1983.

413. Chemoenzymatic Synthesis of Sugar Fluorinated Nucleotide: Useful Mechanistic Probes for Glycosyltransferases the Glycosyltransferase Mechanism M.D. Burkart, S.P. Vincent, A. Düffels, B.W. Murray, S.V. Ley and C-H. Wong, Bioorg. Med. Chem., 2000, 8, 1937.

412. Polymer-Supported Reagents as Vesatile Tools in Combinatorial Chemistry and Total Synthesis G. Brusotti, M. Calderelli, J. Habermann, S.V. Ley and J. S. Scott, 4th International Electronic Conference on Synthetic Organic Chemistry, ECSOC 4, September 1-30, 2000. http://www.unibas.ch/mdpi/ecsoc-4.htm

411. Protecting Groups; Effects on Reactivity, Glycosylation, Stereoselectivity and Coupling Efficiency L.G. Green and S.V. Ley in “Oligosaccharides in Chemistry and Biology: A Comprehensive Handbook”, Vol 1 ed. G. Hart, P. Sinäy and B. Ernst, Wiley-VCH, Weinheim, Germany 2000, 17, 427.

410. Diastereoselective Oxygen to Carbon Rearragements of Anomerically Linked Enol Ethers and the Total Synthesis of (+)-S,S-(cis-6-Methyltetrahydropyran-2-yl)acetic Acid a Component of Civet D.J. Dixon, S.V. Ley and E.W. Tate, J. Chem. Soc., Perkin Trans. 1, 2000, 2385.

409. Sweet Dreams: New Strategies and Methods for Complex Oligosaccharide Assembly S.V. Ley, Ernst Schering Research Foundation, Lecture Series, 2000, 37, 7. ISSN 1431-5033.

408. The Synthesis of Mono and Bicyclic Ethers via Acid Catalysed Ring-opening Cyclisation of Tetrahydropyranyl Ether Derivatives D.J. Dixon, S.V. Ley and E.W. Tate, J. Chem. Soc., Perkin Trans. 1, 2000, 1829.

407. Oxygen to Carbon Rearrangements of Anomerically Linked Alkenols from Tetrahydropyran Derivatives: An Investigation of the Reaction Mechanism via a Double Isotopic Labelling Crossover Study M.F. Buffet, D.J. Dixon, G.L. Edwards, S.V. Ley and E.W. Tate, J. Chem. Soc., Perkin Trans. 1, 2000, 1815.

406. A Short and Efficient, Stereoselective Synthesis of the Potent, Orally Active Anti-Histamine Agent CMI-977 D.J. Dixon, S.V. Ley, D.J. Reynolds and M. Chorgharde, Syn. Commun., 2000, 30, 1955.

405. 1,7- Asymmetric Induction of Chirality in a Mukaiyama Aldol Reaction using p-Allyltricarbonyliron Lactone Complexes: Highly Diastereoselective Synthesis of α-Substituted β-Hydroxy Carbonyl Compounds S.V. Ley and E.A. Wright, J. Chem. Soc., Perkin Trans. 1, 2000, 1677.

404. Tri-n-butyl [2-(trimethylsilyl)-ethoxymethoxymethyl] stannane: A Convenient Hydroxymethyl Anion Equivalent E. Fernández-Megia and S.V. Ley, Synlett, 2000, 455.

403. Synthesis of High-Mannose Type Neoglycolipids Active Targeting of Liposomes to Macrophages for Gene Therapy A. Düffels, L. G. Green, S.V. Ley and A.D. Miller, Chem. Eur. J., 2000, 6, 1416.

402. Methyl 2,3-O-(octahydro-6,6′-bi-2H-pyran-2,2′-diyl) a-D-galactopyranoside S.V. Ley and H.M.I. Osborn, Org. Synth., 2000, 77, 212.

401. Clean and Efficient Synthesis of Azo-Dyes using Polymer Supported Reagents M. Calderelli, I.R. Baxendale and S.V. Ley, Green Chemistry, 2000, 43.

400. Rapid Assembly of Oligosaccharides: 1,2-Diacetal Mediated Reactivity Tuning in the Coupling of Glycosyl Fluorides D.K. Baeschlin, L.G. Green, M.G. Hahn, S.J. Ince and S.V. Ley, Tetrahedron Asymmetry, 2000, 11, 173.

399. Polymer Supported Reagents in Synthesis: Preparation of Bicyclo [2.2.2] octane Derivatives via Tandem Michael Addition Reactions and Subsequent Combinatorial Decoration S.V. Ley and A. Massi, J. Combinatorial Chem., 2000, 2, 104.

398. Use of the Temporary Connection in Organic Synthesis L.R. Cox and S.V. Ley in Templated Organic Synthesis. Ed F. Diederich and P.J. Stang Wiley-VCH, Weinheim, Germany, 2000, 275.

397. A Short and Efficient Steroselective Synthesis of the Polyhydroxylated Macrolactone (+)-Aspicilin D.J. Dixon, A.C. Foster and S.V. Ley, Org. Lett., 2000, 2, 123.

396. 1,2-Diacetals in Synthesis: Total Synthesis of a Glycosylphosphatidylinositol Anchor of Trypanosoma brucei D.K. Baeschlin, A.R. Chaperon, L.G. Green, M.G. Hahn, S.J. Ince, S.V. Ley, Chem. Eur.J., 2000, 6, 172.

395. Reductive Decomplexation of p-Allyltricarbonyliron Lactone Complexes: A New Route to Stereodefined Acyclic 1,5-Diols and 1,5,7-Triols S.V. Ley, S. Burckhardt, L.R. Cox and J.M. Worrall, J. Chem. Soc., Perkin Trans. 1, 2000, 211.