Dr Rebecca Myers

IMG_7966Rebecca undertook her first degree in Chemistry at Imperial College (1994-1997). She followed this with a PhD in Organic Chemistry at the University of Cambridge under the supervision of Prof Chris Abell (1997-2001). Her first year as a Postdoctoral Research Associate in the Ley group was spent working on a collaborative medicinal chemistry project on C-reactive protein (2001-2002). After returning from a break in the United States, she resumed her role in the Ley group in 2004. Rebecca was promoted to Senior Research Associate in 2010. She was the Associate Director of the CRUK-funded Cambridge PhD Training Programme in Chemical Biology and Molecular Medicine (2006-2015) and is currently Head of Graduate Recruitment for the Chemistry Department.

Machine-Assisted Organic Synthesis S.V. Ley, D.E. Fitzpatrick, R.M. Myers, C. Battilocchio, R.J. Ingham Angew. Chem. Int. Ed. 201554, 10122-10136

Chemistry in a changing world S.V. Ley, R.M. Myers, D.E. Fitzpatrick L’Actualite Chimique, Fevrier-Mars, 2015393-394, 96-101

Organic Synthesis: March of the Machines S.V. Ley, D.E. Fitzpatrick, R. J. Ingham, R.M. Myers, Angew. Chem. Int. Edn. 201554, 3449-3464

 Flow chemistry meets advanced functional materials R.M. Myers, D.E. Fitzpatrick, R.M. Turner, S.V. Ley, Chem. Eur. J. 2014, 20, 12348–12366

Design, synthesis, and biological evaluation of an allosteric inhibitor of HSET that targets cancer cells with supernumerary centrosomes C.W. Watts, F.R. Richards, A. Bender, P.J. Bond, O. Korb, O. Kern, M. Riddick, P. Owen, R.M. Myers, J. Raff, F. Gergely, D.I. Jodrell, S.V. Ley, Chem. Biol201320, 1399–1410

The evolution of immobilised reagents and their application in flow chemistry for the synthesis of natural products and pharmaceutical compounds by R.M. Myers, K.A. Roper, I.R. Baxendale and S.V. Ley. In ‘Modern Tools for the Synthesis of Complex Bioactive Molecules’, Ed. J. Cossy, S. Arseniyadis, J. Wiley, N.Y., ISBN 978-0-470-61618-5, 2012, Ch 11, p. 359-394

A-Ring dihalogenation increases the cellular activity of combretastatin-templated tetrazoles T.M. Beale, D.M. Allwood, A. Bender, P.J. Bond, J.D. Brenton, D.S. Charnock-Jones, S.V. Ley, R.M. Myers*, J.W. Shearman, J. Temple, J. Unger, C.A. Watts and J. Xian, ACS Med. Chem. Lett.2012, 3, 177-181

Increased endothelial cell selectivity of triazole-bridged dihalogenated A-ring analogues of combretastatin A-1 T.M. Beale, P.J. Bond, J.D. Brenton, D.S. Charnock-Jones, S.V. Ley and R.M. Myers*, Bioorg. Med. Chem201220, 1749-1759

Allosteric modulation of hormone release by thyroxine and corticosteroid-binding globulins X. Qi, F. Loiseau, W.L. Chan, Y. Yan, Z. Wei, L-G. Milroy, R.M. Myers, S.V. Ley, R.J. Read, R.W. Carrell and A. Zhou, J. Biol. Chem. 2011, 286, 16163-16173

Total synthesis of subereomollines A and B J.W. Shearman, R.M. Myers, J.D. Brenton and S.V. Ley, Org. Biomol. Chem. 2011, 9, 62-65

Antivascular and anticancer activity of dihalogenated A-ring analogues of combretastatin A-4 T.M. Beale, R.M. Myers,* J.W. Shearman, S. Charnock-Jones, J.D. Brenton, F.V. Gergely and S.V. Ley, Med. Chem. Commun. 2010, 1, 202-208

Total synthesis of the bromotyrosine-derived natural products ianthellin, 5-bromoverongamine and JBIR-44 J.W. Shearman, R.M. Myers, T.M. Beale. J.D. Brenton, S.V. Ley, Tetrahedron Lett. 2010, 51, 4812-4814

Cancer, chemistry, and the cell: molecules that interact with the neurotensin receptors R.M. Myers,* J.W. Shearman, M.O. Kitching, A. Ramos-Montoya, D.E. Neal and S.V. Ley, ACS Chem. Biol. 2009, 7, 503-525

Synthesis of spiroketals in compounds with two carbon-heteroatom bonds S.V. Ley, R.M. Myers and L.-G. Milroy in Science of Synthesis, 2007, Vol 29, Product Class 9: Spiroketals 613-689. Ed. S. Warriner. Houben-Weyl, Thieme-Verlag, Stuttgart, Germany

Chiral glycolate equivalents for the asymmetric synthesis of γ-hydroxycarbonyl compounds S.V. Ley, T.D. Sheppard, R.M Myers, M.S. Chorghade, Bull. Chem. Soc. Jpn. 2007, 80, 1451-1472

Targeting C-reactive protein for the treatment of human cardiovascular disease M.B. Pepys, G.M. Hirschfield, G.A. Tennent, J.R. Gallimore, M.C. Kahan, V. Bellotti, P.N. Hawkins, R.M. Myers, M.D. Smith, A. Polara, A.J.A. Cobb, S.V. Ley, J.A. Aquilina, C.V. Robinson, I. Sharif, G.A. Gray, C.A. Sabin, M.C. Jenvey, S.E. Kolstoe, D. Thompson and S.P. Wood, Nature 2006440, 1217-1221

Polymer-supported reagents and scavengers in synthesis in drug discovery technologies S.V. Ley, I.R. Baxendale and R.M. Myers in Comprehensive Medicinal Chemistry II, 2006, 3, 791-836. ISBN: 0080445136. Eds. D.J. Triggle and J.B. Taylor. Elsevier, Oxford

Natural products as an inspiration for the discovery of new high throughput chemical synthesis tools S.V. Ley, I.R. Baxendale, D.A. Longbottom and R.M. Myers in Drug Discovery & Development, 2006. Ed. M.S. Chorghade. John Wiley & Sons, ISBN 0-471-39848-9

Polymer supported reagents and scavengers in the synthesis of natural products In Combinatorial Synthesis of Natural Product-Based Libraries, 2006, 6, 131-163. Ed. A.M. Boldi, CRC Press, Boca-Raton, Florida, USA. ISBN 0-8493-4000-4. S.V. Ley,* I.R. Baxendale and R.M. Myers

Evolution or revolution: the challenge to the modern medicinal chemist S.V. Ley, I.R. Baxendale and R.M. Myers in The Chemical Theatre of Biological Systems, 2005. Eds. M.G. Hicks and C. Kettner, Proc. Beilstein-Institut Workshop, May 2004, Bozen, Italy. ISBN 3-8325-1019-2

Synthesis of the thapsigargins S.V. Ley, A. Antonello, E.P. Balskus, D.T. Booth, S.B. Christensen, E. Cleator, H. Gold, K. Högenauer, U. Huenger, R.M. Myers, S.F. Oliver, O. Simic, M.D. Smith, H. Søhoel and A.J.A. Woolford, Proc. Nat. Acad. Sci2004101, 12073-12078

Derek Harold Richard Barton S.V. Ley and R.M Myers, Biog. Mem. Fell. Royal Society, London, 2002, 48, 1-23

Reductive cleavage of N-O bonds using SmI2 in a Traceless Release Strategy for Solid-phase Synthesis R.M. Myers, S.P. Langston, S.P. Conway and C. Abell, Org. Lett. 2000, 2, 1349-1352 Email: rmm32@cam.ac.uk Linkedin profile