Dr Ricardo Labes

Ricardo obtained his first degree in chemistry at Regional University of Blumenau (2009, Blumenau, Brazil) then completed a Master in organic chemistry under the supervision of Professor Francisco de Assis Marques at Federal University of Parana (2012, Curitiba, Brazil) and a PhD in the same University working in the development of ligands for the addition of organozinc reagents to carbonyl compounds.

During his PhD Ricardo spent one year as a visiting PhD at Prof Ley’s group in the University of Cambridge working in two main projects, the development of a synthetic methodology to obtain chiral alkynols in continuous flow, by zinc salt mediated stereoselective alkynylation of aldehydes, and the development of an automated multi-step platform to synthetize 2-pyrazolines. Ricardo returned to the Ley group in 2016 as a post-doctoral research associate under an Ely Lilly-funded position for two years.

His current research involves accelerating the preparation of pharmaceutical compounds via the development of machine-assisted reaction sequences and the exploitation of new aminating and oxidizing methodologies using Continuous Flow Chemistry.

Organic photocatalysis for the radical couplings of boronic acid derivatives in batch and flow 

Rapid Continuous Ruthenium-Catalysed Transfer Hydrogenation of Aromatic Nitriles to Primary Amines R. Labes, D. González-Calderón, C. Battilocchio, C. Mateos, G.R. Cumming, O. de Frutos, J.A. Rincón and S.V. Ley Synlett 2017; 28: 2855-2858

Chemoselective Continuous Ru-Catalyzed Hydrogen-Transfer Oppenauer-Type Oxidation of Secondary Alcohols  R. Labes, C. Battilocchio, C. Mateos, G.R. Cumming, O. de Frutos, J.A. Rincón, K. Binder and S.V. Ley Org. Process Res. Dev., 2017, 21, 1419–1422

New chiral ligands derived from (+) and (−)-α-pinene for the enantioselective addition of diethylzinc to aldehydes G. Frensch, R. Labes,  C.L. Wosch, L.S. Munaretto, K.S. Salome, P.G. Guererro, F.A. Marques Tetrahedron Lett. 2016, 57, 420-422

Cyclopropanation using flow- generated diazo compounds N.M. Roda, D.N. Tran, C. Battilocchio, R. Labes, R.J. Ingham, J.M. Hawkins; S.V. Ley Org. Biomol. Chem. 2015, 13, 2550-2554

Stereoselective addition of diethylzinc to aldehydes using chiral β-hydroxy-2-oxazolines as catalysts F.A. Marques; C.L. Wosch, G. Frensch, R. Labes, B.H.L.N.S. Maia, K.S. Salome, A. Barison, P.G. Guerrero J. Brazilian Chem. Soc. 2014, 26, 165-170

One-pot synthesis of telluroketene acetals and haloketene acetals using sp2 geminated hetero organobismetallic intermediates P.G. Guerrero, P.R. Oliveira, A.C. Baroni, F.A. Marques, R. Labes, M.J. Dabdoub Tetrahedron Lett. 2012, 53, 1582-1586

Email:  rl505@cam.ac.uk