Dr Ricardo Labes

Ricardo obtained his first degree in chemistry at Regional University of Blumenau (2009, Blumenau, Brazil) then completed a Master in organic chemistry under the supervision of Professor Francisco de Assis Marques at Federal University of Parana (2012, Curitiba, Brazil) and a PhD in the same University working in the development of ligands for the addition of organozinc reagents to carbonyl compounds.

During his PhD Ricardo spent one year as a visiting PhD at Prof Ley’s group in the University of Cambridge working in two main projects, the development of a synthetic methodology to obtain chiral alkynols in continuous flow, by zinc salt mediated stereoselective alkynylation of aldehydes, and the development of an automated multi-step platform to synthetize 2-pyrazolines. Ricardo returned to the Ley group in 2016 as a post-doctoral research associate under an Ely Lilly-funded position for two years.

His current research involves accelerating the preparation of pharmaceutical compounds via the development of machine-assisted reaction sequences and the exploitation of new aminating and oxidizing methodologies using Continuous Flow Chemistry.


11. C–H functionalisation of aldehydes using light generated, non-stabilised diazo compounds in flow P. Dingwall, A. Greb, L. N. S. Crespin, R. Labes, B. Musio, J.S. Poh, P. Pasau, D. C. Blakemore and S. V. Ley Chem. Comm. 2018, 54, 11685 – 11688

10. A Convergent Continuous Multistep Process for the Preparation of C4‐Oxime-Substituted Thiazoles E. Godineau, C. Battilocchio, M. Lehmann, S. V. Ley, R. Labes, L. Birnoschi, S. Subramanian, C. S. Prasanna, A. Gorde, M. Kalbagh, V. Khade, A. Scherrer and A. C. O’Sullivan Org. Process Res. Dev. 2018, 22, 955−962

9. Integrated plug flow synthesis and crystallisation of pyrazinamide C. Daniel Scott, R. Labes, M. Depardieu, C.Battilocchio, M. G. Davidson, S. V. Ley, C. C. Wilson and K. Robertson React. Chem. Eng., 2018, 3, 631

8. Preparation of homoallylic amines via a three-component coupling process 

7. Organic photocatalysis for the radical couplings of boronic acid derivatives in batch and flow

6. Rapid Continuous Ruthenium-Catalysed Transfer Hydrogenation of Aromatic Nitriles to Primary Amines R. Labes, D. González-Calderón, C. Battilocchio, C. Mateos, G.R. Cumming, O. de Frutos, J.A. Rincón and S.V. Ley Synlett 2017; 28: 2855-2858

5. Chemoselective Continuous Ru-Catalyzed Hydrogen-Transfer Oppenauer-Type Oxidation of Secondary Alcohols  R. Labes, C. Battilocchio, C. Mateos, G.R. Cumming, O. de Frutos, J.A. Rincón, K. Binder and S.V. Ley Org. Process Res. Dev., 2017, 21, 1419–1422

4. New chiral ligands derived from (+) and (−)-α-pinene for the enantioselective addition of diethylzinc to aldehydes G. Frensch, R. Labes,  C.L. Wosch, L.S. Munaretto, K.S. Salome, P.G. Guererro, F.A. Marques Tetrahedron Lett. 2016, 57, 420-422

3. Cyclopropanation using flow- generated diazo compounds N.M. Roda, D.N. Tran, C. Battilocchio, R. Labes, R.J. Ingham, J.M. Hawkins; S.V. Ley Org. Biomol. Chem. 2015, 13, 2550-2554

2. Stereoselective addition of diethylzinc to aldehydes using chiral β-hydroxy-2-oxazolines as catalystsF.A. Marques; C.L. Wosch, G. Frensch, R. Labes, B.H.L.N.S. Maia, K.S. Salome, A. Barison, P.G. Guerrero J. Brazilian Chem. Soc. 2014, 26, 165-170

1. One-pot synthesis of telluroketene acetals and haloketene acetals using sp2 geminated hetero organobismetallic intermediates P.G. Guerrero, P.R. Oliveira, A.C. Baroni, F.A. Marques, R. Labes, M.J. Dabdoub Tetrahedron Lett. 2012, 53, 1582-1586

 

Email:  rl505@cam.ac.uk