Dr Zoe E. Wilson


Zoe Wilson grew up in Warkworth, New Zealand, before moving to Auckland to attend the University of Auckland where she completed a Bachelor of Science in Medicinal Chemistry in 2005. In 2006 she completed a BSc (Hons) in Medicinal Chemistry under the supervision of Professor Margaret Brimble, working on the synthesis of anti-Helicobacter pylori compounds. She was then funded by an University of Auckland scholarship to carry out Ph.D. research with Professor Brimble into the synthesis of the extremophile natural product berkelic acid. Upon completion of her PhD in 2010, Zoe was awarded a Newton International Fellowship by the Royal Society, allowing her to move to the United Kingdom in January 2011 to join the Ley group. In the Ley group, Zoe has been working on the synthesis of the natural products azadirachtin and plantazolicin A and B. She has also been developing methodology to overcome synthetic challenges identified by the synthesis of these complex targets using flow technology. Upon completing her Newton Fellowship in early 2013, Zoe was appointed as Post-Doctoral Research Associate, funded by Professor Ley’s EPSRC Critical Mass Grant.  She was also appointed as a College Lecturer and Fellow of Murray Edwards College (New Hall) in October 2013, where she has additionally been Director of Studies for Chemistry since 2015.

Utilization of flow chemistry in catalysis: New avenues for the selective synthesis of Bis(indolyl)methanes S.S. Mohapatra, Z.E. Wilson, S. Roy, S.V. Ley, Tetrahedron201773, 1812-1819

The total synthesis of the bioactive natural product Plantazolicin A and its biosynthetic precursor Plantazolicin B S. Fenner, Z.E. Wilson and S.V. Ley, Chem. Eur. J. 201622, 15902-15912

Controlled Generation and Use of CO in Flow S.V.F. Hansen, Z.E. Wilson, T. Ulven and S.V. Ley, React. Chem. Eng.20161, 280-287

Synthesis of natural and unnatural cyclooligomeric depsipeptides enabled by flow chemistry D. Lücke, T. Dalton, S.V. Ley, Z.E. Wilson Chem. Eur. J. 201622, 4206-4217

Total syntheses of linear polythiazole/oxazole plantazolicin A and its biosynthetic precursor plantazolicin B Z.E. Wilson, S. Fenner, S.V. Ley Angew. Chem. Int. Edn. 201554, 1284-1288 Featured as a SynStory article and on the cover of SYNFORM, 07, 2015, A95-A97.

The rapid synthesis of oxazolines and their heterogeneous oxidation to oxazoles under flow conditions S. Glockner, D.N. Tran, R.J. Ingham, S. Fenner, Z.E. Wilson, C. Battilocchio, S.V. Ley Org. Biomol. Chem. 201513, 207

Total syntheses of linear polythiazole/oxazole plantazolicin A and its biosynthetic precursor plantazolicin B, Z.E. Wilson, S. Fenner, S.V. Ley Angew. Chem. Int. Edn. 2015, 54, 1284-1288

Formal synthesis of berkelic acid: a lesson in alpha-alkylation chemistry M.C. McLeod, Z.E. Wilson , M.A. Brimble* J. Org. Chem.201277, 400-416

An enantioselective formal synthesis of berkelic acid M.C. McLeod, Z.E. Wilson, M.A. Brimble* Org. Lett. 201113, 19, 5382-5385

Synthetic approaches to [5,6]-benzannulated spiroketal natural products M.C. McLeod, M.A. Brimble*, D.C.K. Rathwell, Z.E. Wilson, T.-Y. Yuen Pure Appl. Chem. 2011, 8, 1379–1390

A flexible approach to 6,5-benzannulated spiroketals Z.E. Wilson, J.G. Hubert, M.A. Brimble* Eur. J. Org. Chem. 201120-21, 3938-3945

Synthesis of benzannulated spiroketals using an oxidative radical cyclization J. Sperry, Y.-C. Liu, Z.E. Wilson, J.G. Hubert, M.A. Brimble* Synthesis20119, 1383-1398

Isolation, biological activity and synthesis of benzannulated spiroketal natural products J. Sperry, Z.E. Wilson, D.C.K. Rathwell, M.A. Brimble* Nat. Prod. Rep. 201027, 1117-1137

A flexible asymmetric synthesis of the tetracyclic core of berkelic acid using
a novel Horner-Wadsworth-Emmons/oxa-Michael cascade 
Z. E. Wilson and M. A. Brimble* Org. Biomol. Chem. 20108, 1284-1286

Molecules derived from the extremes of life Z.E. Wilson and M.A. Brimble* Nat. Prod. Rep.200926, 44-71. Featured as an Instant insight article in Chemical Biology (Featured on the cover of the issue) Life at the extremes  Chem. Biol. 2008, 3, B95

Anti-Helicobacter pylori activity of derivatives of the phthalide-containing antibacterial agents spirolaxine methyl ether, CJ-12,954, CJ-13,013, CJ-13,102, CJ-13,104, CJ-13,108 and CJ-13,015 F.J. Radcliff, J.D. Fraser, Z.E. Wilson, A.M. Heapy, J.E. Robinson, C.J. Bryant, C.L. Flowers, M.A. Brimble* Bioorg. Med. Chem. 200816, 6179-6185

Synthesis of indole analogues of the anti-Helicobacter pylori compounds
CJ-13,015, CJ-13,102, CJ-13,104 and CJ-13,108 
Z.E. Wilson, A.M. Heapy , M.A. Brimble* Tetrahedron, 2007, 63, 5379-5385

Email: zw261@cam.ac.uk    LinkedIn Profile