Dr Biagia Musio

Biagia Musio gained her degree in Chemistry and Pharmaceutical Technology at the University of Bari, Italy, in 2004. This included an 18-month research project in organic synthetic methodologies working on the synthesis and the reactivity of oxazolinylaziridines, in Prof Saverio Florio’s group.

In March 2007 she joined the group of Prof Mike Shipman at the University of Warwick as visiting researcher and in 2008 she  was awarded a PhD in Chemistry (Doctoral School of Applied Chemical and Enzymatic Synthesis) working on the development of new stereoselective synthetic methodologies of small molecules by using organometallic reagents and palladium catalysis.

Biagia was an Assistant Researcher  at the University of Bari in Prof Renzo Luisi’s group from 2008-2013. During this time she was involved with a number of projects mainly focused on elucidation of the structure in solution of organometallic intermediates by Nuclear Magnetic Resonance and FT-IR, and on the molecular dynamics of small molecules. Recently, her major efforts have been orientated towards the development of organic synthesis by using the microreactor technology.

Biagia joined the Ley group in March 2013 as a postdoctoral research associate on the new EPSRC-funded Critical Mass grant working on novel chemical methods in continuous flow.

Combination of Enabling Technologies to Improve and Describe the Stereoselectivity of Wolff–Staudinger Cascade Reaction B. Musio, F. Mariani, E.P. Sliwinski, M.A. Kabeshov, H. Odajima and S.V. Ley, Synthesis201648, 3515-3526

An Orthogonal Biocatalytic Approach for the Safe Generation and Use of HCN in a Multistep Continuous Preparation of Chiral O-Acetylcyanohydrins A. Brahma, B. Musio, U. Ismayilova, N. Nikbin, S.B. Kamptmann, P. Siegert, G.E. Jeromin, S.V. Ley, M. Pohl Synlett 201627, 262-266

Design, synthesis and evaluation of semi-synthetic triazole-containing caffein acid analogues as 5-lipooxygenase inhibitors De Lucia, O Méndez Lucio, B. Musio, A. Bender, M. Listing, S. Dennhardt, A. Koeberle, U. Garscha, R. Rizzo, S. Manfredini, O. Werz, S.V. Ley Eur. J. Med. Chem. 2015101, 573-583

Development of a web-based platform for studying lithiation reactions in silico M.A. Kabeshov, É. Sliwiński, D.E. Fitzpatrick, B. Musio, J.A. Newby, W.D. Blaylock, S.V. Ley Chem. Comm. 2015, 51, 7172-7175

Regio- and stereochemistry of Na-mediated reductive cleavage of alkyl aryl ethers U. Azzena, M. Carraro, C. Meloni, I. Murgia, L. Pisano, M. Pittalis, R. Luisi, B. Musio, L. Degennaro Tetrahedron Asymm. 2014, 25, 1550-1554

Expedient preparation of nazlinine and a small library of indole alkaloids using flow electrochemistry as an enabling technology, M.A. Kabeshov, B. Musio, P.R.D. Murray, D.L. Browne, S.V.Ley Org. Lett., 2014, 16, 4618-4621

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Synthesis of functionalized prylaziridines as potential antimicrobial agents A. Giovine, M. Muraglia, M. A. Florio, A. Rosato, F. Corbo, C. Franchini, B. Musio, L. Degennaro, R. Luisi., Molecules, 2014, 19(8), 11505-11519

Lithiated oxazolinyloxiranes and oxazolinylaziridines: key players in organic synthesis  S. Florio, L. Degennaro, R. Mansueto, B. Musio, F. M. Perna, A. Salomone Pure Appl. Chem., 2014, 86, 6, 913–924

Nitrogen-bearing lithium compounds L. Degennaro, B. Musio, R. Luisi, Lithium compounds in organic synthesis – from fundamentals to applications.,  2014, R. Luisi, V. Capriati, Eds., WILEY-VCH, ISBN: 978-3-527-33343-1

Microreactor-mediated organocatalysis: towards the development of sustainable domino reactions L. Carroccia, B. Musio, L. Degennaro, G. Romanazzi, R. Luisi. J. Flow Chem. 2013, 3, 29–33

Synthesis of 1,2,3,4-tetrahydroisoquinolines by microreactor-mediated thermal isomerization of laterally lithiated arylaziridines A. Giovine, B. Musio, L. Degennaro, A. Falcicchio, A. Nagaki, J- I. Yoshida*, R. Luisi* Chem, Eur. J. 2012, 19, 1872-1876

One-pot preparation of piperazines by ring-opening of non-activated arylaziridines P. Trinchera, B. Musio, L. Degennaro, A. Moliterni, A. Falcicchio, R. Luisi* Org. Biomol. Chem. 2012, 10, 1962-1965

BH3-promoted stereoselective β-lithiation of N-alkyl-2-phenylaziridines U. Azzena, G. Dettori, L. Pisano*, B. Musio, R. Luisi* J. Org. Chem. 2011, 76,2291-2295

Solvent- and temperature-dependent functionalisation of enantioenriched aziridines M.C. De Ceglie, B. Musio, F. Affortunato, A. Moliterni, A. Altomare, S. Florio, R. Luisi* Chem. Eur. J. 2011, 17, 286-296

Microreactor technology as tool for the development of a sustainable synthetic chemistry R. Luisi*, B. Musio, L. Degennaro La Chimica e l’Industria, 2011, 114-123

New Horizons in the chemistry of aziridines F. Affortunato, L. Degennaro, S. Florio*, A. Giovine, R. Luisi, R. Mansueto, B. Musio Conference proceedings Modern Aspects of Chemistry of Heterocycles. Ed. V.G. Kartsev.  International Editorial Board, 2010, 38-49

Lithiation of N-alkyl-(o-tolyl)aziridine: stereoselective synthesis of isochromans M. Dammacco, L. Degennaro, S. Florio*, R. Luisi*, B. Musio, A. Altomare  J. Org. Chem. 2009, 74, 6319-6322

Synthesis of optically active arylaziridines by regio and stereospecific lithiation of N-bus-Pphenylaziridine B. Musio, G. J-. Clarkson, M. Shipman, S. Florio*, R. Luisi Org. Lett. 2009, 11, 325-328

α- vs Ortho-lithiation of N-alkylarylaziridines: probing the role of the nitrogen inversion process F. Affortunato, S. Florio*, R. Luisi*, B. Musio J. Org. Chem. 2008, 73, 9214-9220

A computational study of the effect of C-lithiation on the NMR properties (chemical shifts and coupling constants) of aziridines V. Capriati, S. Florio*, R. Luisi, B. Musio, I. Alkorta*, F. Blanco, J. ElgueroStruct. Chem. 2008, 785-792

Regio- and stereoselective lithiation of 2,3-diphenylaziridines: a multinuclear NMR investigation V. Capriati, S. Florio*, R. Luisi*, A. Mazzanti, B. Musio J. Org. Chem. 2008, 73, 3197-3204

Regio- and stereoselective lithiation and electrophilic substitution reactions of N-alkyl-2,3-diphenylaziridines: solvent effect R. Luisi, V. Capriati, S. Florio*, B. Musio Org. Lett. 2007, 9, 1263-1266

Directed ortho lithiation of N-alkylphenylaziridines V. Capriati, S. Florio*, R. Luisi, B. Musio Org. Lett. 2005, 7, 3749-3752

Synthesis and lithiation of oxazolinylaziridines: the N-substituent effect R. Luisi, V. Capriati, S. Florio*, P. Di Cunto, B. Musio Tetrahedron 2005, 61, 3251-3260

Email: bm450@cam.ac.uk