Dr Daniel Fitzpatrick


Daniel graduated in 2017 with a PhD from the University of Cambridge under the supervision of Prof. Steven V. Ley. For his dissertation he was awarded the 2017 Outstanding Thesis Prize. Prior to Cambridge, he graduated with a Bachelor of Engineering (Hons) with First Class Honours from The University of Auckland in May 2013, specialising in Chemical and Materials Engineering.

Daniel’s current research focusses on bridging Chemistry with Chemical Engineering, with a particular focus on the integration of advanced computer control systems during the synthetic preparation of APIs. He is particularly interested in the development of self-optimising routines for chemical transformations and downstream processing; the utility of self-regulating control strategies in telescoped multi-step reaction sequences; and the application of ‘Big Data’ analysis techniques to process data collected from detectors during reaction procedures.

Outside his research, Daniel is a member of the Post-Doctoral Society of Trinity College, enjoys playing squash and is learning to scuba dive. He is also involved with a start-up software company that has developed chemical inventory software for research laboratories.

15. Across-the-World Automated Optimization and Continuous-Flow Synthesis of Pharmaceutical Agents Operating Through a Cloud-Based Server D.E. Fitzpatrick, T. Maujean, A.C. Evans, and S.V. Ley Angew. Chem. Int. Ed. 2018, 57, 15128 –15132

14. In-line separation of multicomponent reaction mixtures using a new semi-continuous supercritical fluid chromatography system D. E. Fitzpatrick, R. J. Mutton and S. V. Ley React. Chem. Eng., 2018, 3, 799-806

13. Engineering Chemistry to Enable Bioactive Small Molecule Discovery S.V.Ley, D. Fitzpatrick and C. Battilocchio 2018, 184-218 (Ch. 8)in Chemical and Biological Synthesis: Enabling Approaches for Understanding Biology, Ed. N.J. Westwood and A. Nelson, ISBN 978-1-78262-948-1

12. Engineering chemistry for the future of organic synthesis D.E. Fitzpatrick and S.V. Ley Tetrahedron, 2018, 74, 3087-3100

11. Engineering chemistry: integrating batch and flow reactions on a single, automated reactor platform D.E. Fitzpatrick and S.V. Ley, React. Chem. Eng., 20161, 629-635

10. Solvent-free continuous operations using small footprint reactors: a key approach for process intensification T. Ouchi, R.J. Mutton, V. Rojas, D.E. Fitzpatrick, D.G. Cork, C. Battilocchio, S.V. Ley ACS Sustainable Chem. Eng. 2016, 4, 1912-1916

9. Enabling technologies for the future of chemical synthesis D.E. Fitzpatrick, C. Battilocchio, S.V. Ley ACS Central Science 20162, 131-138

8. A novel internet-based reaction monitoring, Control and autonomous self-optimization platform for chemical synthesis D.E. Fitzpatrick, C. Battilocchio, S.V. Ley Org. Process. Res. Dev 201620, 386-394

7. The internet of chemical things S.V. Ley, D.E. Fitzpatrick, R.J. Ingham, N. Nikbin Beilstein Magazine 20151, 11-12

6. Machine-assisted organic synthesis S.V. Ley, D.E. Fitzpatrick, R.M. Myers, C. Battilocchio, R.J. Ingham Angew. Chem. Int. Ed. 201554, 10122-10136

5. Chemistry in a changing world S.V. Ley, R.M. Myers, D.E. Fitzpatrick L’Actualite Chimique, Fevrier-Mars,2015393-394, 96-101

4. Organic synthesis: march of the machines S.V. Ley, D.E. Fitzpatrick, R.J. Ingham, R.M. Myers Angew. Chem. Int. Edn201554, 3449-3464

3. A systems approach towards an intelligent and self-controlling platform for integrated continuous reaction sequences R.J. Ingham, C. Battilocchio, D.E. Fitzpatrick, E. Sliwinski, J.M. Hawkins, S.V. Ley Angew. Chem. Int. Edn201554, 144-148

2. Development of a web-based platform for studying lithiation reactions in silico M.A. Kabeshov, E. Sliwinski, D.E. Fitzpatrick, B. Musio, J.A. Newby, W.D.W. Blaylock, S.V. Ley, Chem. Commun201551, 7172-7175

1. Flow chemistry meets advanced functional materials R.M. Myers, D.E. Fitzpatrick, R.M. Turner, S.V. Ley Chem. Eur. J201420, 12348–12366