Claudio spent his childhood in the stunning area of Tolfa and Allumiere in the province of Rome (Italy). He carried out his undergraduate research at “Sapienza” University of Rome where he received his degree in Medicinal Chemistry in 2008 (cum laude). He was then awarded the CARIPLO fellowship to work on the development of a novel class of anti-mycobacterial agents.
In 2009, he started his PhD with Prof Mariangela Biava focusing his research programme on developing new molecular hybrids, nitric oxide donors for the treatment of pain and inflammation (Rottapharm scholarship). He was awarded two prizes for his PhD Thesis (Best PhD and Doctor Europeaus, awarded in 2015 and 2013, respectively). Claudio came to work in Cambridge in 2011 to work with Ian Baxendale (now Professor at Durham University) and Steve Ley on enabling technologies.
In 2012 Claudio was appointed to a Pfizer-funded research position in the Ley group to conduct various chemical synthesis projects under our Open Innovation programme. His research concentrated on the application of flow technologies to bridge the gap between industry and academia (including heterogeneous and homogeneous flow catalysis, process intensification and multistep syntheses).
Claudio is a Research Associate at Homerton College and currently working on a Syngenta-funded position in the Ley group. His current research deals with the development of robust and scalable flow methodology for Process Development and Manufacturing applications. He’s committed to pushing the boundaries of scientific discoveries towards novel strategies to build molecules. He is involved in the development of modular, self-regulating and self–optimising machines to aid the process of molecular discovery and development. Claudio is interested in the development of new tools for delivering better chemistries. Claudio is involved in Knowledge Transfer programmes (academia and industry) in Ley group.
Rapid asymmetric synthesis of disubstituted allenes by coupling of flow-generated diazo compounds and propargylated amines J-S. Poh, S. Makai, T. v.Keutz, D.N. Tran, C. Battilocchio, P. Pasau, S.V. Ley Angew. Chem. Int. Ed. 2017, 56, 1864-1868
Continuous flow hydration of pyrazine-2-carbonitrile in a manganese dioxide column reactor C. Battilocchio, S-H. Lau, J.M. Hawkins, S.V. Ley Org. Synth. 2017, 94, 34-45
A multicomponent approach for the preparation of homoallylic alcohols J-S. Poh, S-H. Lau, I.G. Dykes, D.N. Tran, C. Battilocchio and S.V. Ley, Chem. Sci. 2016, 7, 6803-6807
Taming hazardous chemistry by continuous flow technology M. Movsisyan, E.I.P. Delbeke, J.K.E.T. Berton, C. Battilocchio, S.V. Ley and C.V. Stevens, Chem. Soc. Rev., 2016, 45, 4892-4928
Solvent-free continuous operations using small footprint reactors: a key approach for process intensification T. Ouchi, R.J. Mutton, V. Rojas, D.E. Fitzpatrick, D.G. Cork, C. Battilocchio, S.V. Ley ACS Sustainable Chem. Eng. 2016, 4, 1912-1916
Iterative reactions of transient boronic acids enable sequential C-C bond formation C. Battilocchio, F. Feist, A. Hafner, M. Simon, D.N. Tran, D.M. Allwood, D.C. Blakemore, S.V. Ley Nature Chem. 2016, 8, 360-367
Enabling technologies for the future of chemical synthesis D.E. Fitzpatrick, C. Battilocchio, S.V. Ley ACS Central Science 2016, 2, 131-138
Dynamic flow synthesis of porous organic cages M.E. Briggs, A.G. Slater, N. Lunt, S. Jiang, M.A. Little, R.L. Greenaway, T. Hasell, C. Battilocchio, S.V. Ley, A.I. Cooper Chem. Commun. 2015, 51, 17390-17393
Machine-Assisted Organic Synthesis S.V. Ley, D.E. Fitzpatrick, R.M. Myers, C. Battilocchio, R.J. Ingham Angew. Chem. Int. Ed. 2015, 54, 10122-10136
A versatile room-temperature route to di- and trisubstituted allenes using flow-generated diazo compounds J.S. Poh, D.N. Tran, C. Battilocchio, J.M Hawkins, S.V. Ley Angew. Chem. Int. Ed. 2015, 54, 7920-7923
Machines vs malaria: a flow-based preparation of the drug candidate OZ439 S-H Lau, A. Galván, R.R. Merchant, C. Battilocchio, J.A. Souto, M.B. Berry, S.V. Ley Org. Lett. 2015, 17, 3218-3221
Design, synthesis and evaluation of tetra substituted pyridines as potent 5-HT2C receptor agonists G. Rouquet, D.E. Moore, M. Spain, D.M. Allwood, C. Battilocchio, D.C. Blakemore, P.V. Fish, S. Jenkinson, A.S. Jessiman, S.V. Ley, G. McMurray, R.A.Storer, ACS Med. Chem. Lett. 2015, 6, 329-333
Flow cycloproponation using in-situ generated diazo compounds N.M. Roda-Monsalvez, D.N. Tran, C. Battilocchio, R. Labes, R.J. Ingham, J.M.Hawkins, S.V. Ley Org. Biomol. Chem. 2015, 13, 2550-2554
Flow chemistry as a discovery tool to access sp2–sp3 cross-coupling reactions via diazo compounds, D.N. Tran, C. Battilocchio, S. Lou, J. M. Hawkins, S.V. Ley Chem. Sci, 2015, 6, 1120-1125
A systems approach towards an intelligent and self-controlling platform for integrated continuous reaction sequences, R.J. Ingham, C. Battilocchio, D.E. Fitzpatrick, E. Sliwinski, J.M. Hawkins, S.V. Ley Angew. Chem. Int. Ed., 2015, 54, 144-148
The rapid synthesis of oxazolines and their heterogeneous oxidation to oxazoles under flow conditions, S. Glockner, D.N. Tran, R.J. Ingham, S. Fenner, Z.E. Wilson, C. Battilocchio, S.V. Ley Org. Biomol. Chem., 2015, 13, 207
Process intensification for the continuous flow hydrogenation of ethyl nicotinate, T. Ouchi, C. Battilocchio, J.M. Hawkins, S.V. Ley Org. Process Res. Dev., 2014, 18, 1560-1566
Flow based cerium oxide-enhanced low-level palladium Sonogashira and Heck coupling reactions by perovskite type oxide catalysts, C. Battilocchio, B.N. Bhawal, R. Chorghade, B.J. Deadman, J.M. Hawkins and S.V. Ley, Israel Journal of Chem., 2014, 54, 371-380
Sustainable flow Oppenauer oxidation of secondary benzylic alcohols with a heterogeneous zirconia catalyst R. Chorghade, C. Battilocchio, J.M. Hawkins, S.V. Ley, Org. Lett. 2013, 15, 5698-5701
A class of pyrrole derivatives endowed with analgesic/anti-inflammatory activity C. Battilocchio, G. Poce, S. Alfonso, G. C. Porretta, S. Consalvi, L. Sautebin, S. Pace, A. Rossi, C. Ghelardini, L. Di Cesare Mannelli, S. Schenone, A. Giordani, L. Di Francesco, P. Patrignani, M Biava, Bioorg. Med Chem. 2013, 21, 3695–3701
A prototype device for evaporation in batch and flow chemical processing B.J. Deadman, C. Battilocchio, E. Sliwinski, S.V. Ley, Green Chem., 2013, 15, 2050-2055
A machine-assisted flow synthesis of SR48692: a probe for the investigation of neurotensin receptor-1 C. Battilocchio, B.J. Deadman, N. Nikbin, M.O. Kitching, I.R. Baxendale, S.V. Ley, Chem. Eur. J. 2013, 19, 7917-7930.
A mild and efficient flow procedure for the transfer hydrogenation of ketones and aldehydes using hydrous zirconia C. Battilocchio, J.M. Hawkins, S.V. Ley, Org. Lett. 2013, 15, 2278-2281
Flow synthesis and biological studies of an analgesic adamantane derivative that inhibits P2X7-evoked glutamate release C. Battilocchio, L. Guetzoyan, C. Cervetto, L. Di Cesare Mannelli, D. Frattaroli, I. R. Baxendale, G. Maura, A. Rossi, L. Sautebin, M. Biava, C. Ghelardini, M. Marcoli, S.V. Ley, A.C.S. Med. Chem. Lett. 2013, 4, 704-709
Improving the solubility of a new class of antiinflammatory pharmacodynamic hybrids that release nitric oxide and inhibit cycloxygenase-2 isoenzyme M. Biava, C. Battilocchio, G. Poce, S. Alfonso, S. Consalvi, G. C. Porretta, S. Schenone, V. Calderone, A. Martelli, L. Testai, C. Ghelardini, L. Di Cesare Mannelli, L. Sautebin, A. Rossi, A. Giordani, P. Patrignani, M. Anzini Eur J. Med. Chem. 2012, 287–298
A flow-based synthesis to 2-aminoadamantane-2-carboxylic acid C. Battilocchio,* I.R. Baxendale, M. Biava, M.O. Kitching, S.V. Ley, Org. Process Res. Dev. 2012, 16, 798–810
Scale-up of flow assisted synthesis of C2-symmetric chiral PyBox-ligands C. Battilocchio, M. Baumann, I.R. Baxendale, M. Biava, M.O. Kitching, S.V. Ley, R.E. Martin,* S.A. Ohnmacht, N.D.C. Tappin, Synthesis 2012, 44, 635-647
MmpL3 is the cellular target of the antitubercular pyrrole derivative BM212 V. La Rosa, G. Poce, J. Ortiz Canseco, S. Buroni, M.R. Pasca, M. Biava, R.M. Raju, G.C. Porretta, S. Alfonso, C. Battilocchio, B. Javid, F. Sorrentino, T.R. Ioerger, J.C. Sacchettini, F. Manetti, M. Botta, A. De Logu,* E.J. Rubin* Antimicrob. Agents Chemother., 2012, 56, 324-331
Novel analgesic/anti-inflammatory agents: diarylpyrrole acetic esters endowed with nitric oxide releasing properties M. Biava,* G.C. Porretta, G. Poce, C. Battilocchio, S. Alfonso, M. Rovini, S. Valenti, G. Giorgi, V. Calderone, A. Martelli, L. Testai, L. Sautebin, A. Rossi, G. Papa, C. Ghelardini, L. Di Cesare Mannelli, A. Giordani, P. Anzellotti, A. Bruno, P. Patrignani, M. Anzini, J. Med. Chem., 2011, 54, 7759-7771
Enlarging the NSAIDs family: ether, ester and acid derivatives of the 1,5-diarylpyrrole scaffold as novel anti-inflammatory and analgesic agents M. Biava,* G.C. Porretta, G. Poce, C. Battilocchio, M. Botta, F. Manetti, M. Rovini, A. Cappelli, L. Sautebin, A. Rossi, C. Pergola, C. Ghelardini, N. Galeotti, F. Makovec, A. Giordani, P. Anzellotti, S. Tacconelli, P. Patrignani, M. Anzini, Curr. Med. Chem. 2011, 18, 1540-1554
Developing pyrrole-derived antimycobacterial agents: a rationallead optimization approach M. Biava,* G.C. Porretta, G. Poce, C. Battilocchio, S. Alfonso, A. de Logu, F. Manetti, M. Botta, Chem. Med. Chem, 2011, 6, 593-599
Novel ester and acid derivatives of the 1,5-diarylpyrrole scaffold as anti-inflammatory and analgesic agents. Synthesis, in vitro and in vivo biological evaluation M. Biava,*G.C. Porretta, G. Poce, C. Battilocchio, F. Manetti, M. Botta, L. Sautebin, A. Rossi, C. Pergola, C. Ghelardini, M. Norcini, F. Makovec, P. Anzellotti, R. Cirilli, R. Ferretti, P. Patrignani, M. Anzini, J. Med. Chem. 2010, 53, 723-733
Identification of a novel pyrrole derivative endowed with antimycobacterial activity and protection index comparable to that of the current antitubercular drugs streptomycin and rifampin M. Biava,* G.C. Porretta, G. Poce, C.Battilocchio, S. Alfonso, A. de Logu, N. Serra, F. Manetti, M. Botta, Bioorg. Med. Chem. 2010, 18, 8076–8084