After two years of preparatory classes (2007 to 2009) for entrance exams into French “Grandes Écoles”, Fabio joined the INP-ENSIACET in Toulouse in 2009 where he obtained a “Diplôme d’Ingénieur” in Chemistry (Master’s degree equivalent) in October 2013.
During his degree, he spent one year on an industrial placement at Novartis in Basel, Switzerland where he worked on the early phase development of continuous flow processes for API synthesis.
In parallel of his last year at INP-ENSIACET he also obtained a Research Master’s degree in Organic Chemistry from the Paul Sabatier University in Toulouse. For his Master’s thesis, he joined the Buchwald Group at MIT (5 months) where he developed and used alternative polar aprotic solvents to tackle solvent-switch problems in continuous manufacturing for API synthesis.
Fabio joined the Ley Group in October 2014 as a PhD student. His research is focused on using photoredox catalysis to enable efficient and scalable C–C cross-couplings. He is funded by Novartis in the Ley group (2014-2018).
Match-Making Reactors to Chemistry: A Continuous Manufacturing-Enabled Sequence to a Key Benzoxazole Pharmaceutical Intermediate F. Susanne, B. Martin, M. Aubry, J. Sedelmeier, F. Lima, S. Sevinc, L. Piccioni, J. Haber, B. Schenkel and F. Venturoni, Org. Process Res. Dev., 2017, 21, 1779–1793
A Lewis Base Catalysis Approach for the Photoredox Activation of Boronic Acids and Esters F. Lima, U.K. Sharma, L. Grunenberg, D. Saha, S. Johannsen, J. Sedelmeier, E.V. Van der Eycken and S.V. Ley, Angew. Chem. Int. Ed., 2017, 56, 15136-15140
Visible light activation of boronic esters enables efficient photoredox C(sp2)-C(sp3) cross-couplings in flow F. Lima, M.A. Kabeshov, D.N. Tran, C. Battilocchio, J. Sedelmeier, G. Sedelmeier, B. Schenkel, S.V. Ley, Angew. Chem. Int. Ed. 2016, 55, 14085-14089
Use of a “catalytic” cosolvent, N,N-dimethyl octanamide, allows the flow synthesis of imatinib with no solvent switch J.C. Yang, D. Niu, B.P. Karsten, F. Lima, S.L. Buchwald* Angew. Chem. Int. Ed. 2016, 55, 2531–2535
A multistep flow process for the synthesis of highly functionalized benzoxazoles J. Sedelmeier*, F. Lima, A. Litzler, B. Martin, F. Venturoni* Org.Lett. 2013, 15, 5546–5549.