Dr Mathieu Lesieur (UCB)

Mathieu is an industrial visitor from UCB. He graduated from the Chemical Engineering School of Mulhouse (ENSCMu, France) in organic and medicinal chemistry. In parallel, he obtained a master degree in organic and medicinal chemistry at the University of Mulhouse. During this period, Mathieu, dedicated one year of his time for an industrial placement in the pharmaceutical company Actelion located in Basel (Switzerland). He was involved in multi-steps synthesis of medicinal compounds and process development.

In 2011, Mathieu moved to the University of St Andrews (Scotland) to complete a PhD in organic and organometallic chemistry under the supervision of Dr Catherine Cazin. During the course of his PhD, Mathieu studied single and dual catalytic systems using Copper, Silver and Palladium N-Heterocyclic carbene complexes.

Currently, Mathieu is a post-doc research associate at UCB Biopharma (Braine l’alleud, Belgium). His research focused on the use of enabling technologies for the development of new methodologies for late-stage C-H oxidation.

Mathieu joined the Ley group in September 2017 for a period of 2 month as a post-doc research associate visitor to develop new methodologies for late-stage C-H oxidation.


1) Highly Active Well-Defined Palladium Precatalysts for the Efficient Amination of Aryls Chlorides. A. Chartoire, M. Lesieur, A. M. Z. Slawin, L. Cavallo, C. S. J. Cazin, S. P. Nolan, Organometallics, 2011, 30, 4432-4436.

2) [Pd(IPr*)(cinnamyl)Cl]: An Efficient Pre-catalyst for the Preparation of Tetra-ortho-substituted Biaryls by Suzuki-Miyaura Cross-Coupling. A. Chartoire, M. Lesieur, L. Falivene, A. M. Z. Slawin, L. Cavallo, C. S. J. Cazin, S. P. Nolan, Chem. Eur. J., 2012, 18, 4517-4521.

3) [Pd(µ-Cl)Cl(IPr*)]2: a highly hindered pre-catalyst for the synthesis of tetra-ortho-substituted biaryls via Grignard reagent cross-coupling. M. Lesieur, A. M. Z. Slawin, C. S. J. Cazin, Org. Biomol. Chem., 2014, 12, 5586-5589.

4) A cooperative Pd-Cu system for direct C-H bond arylation. M. Lesieur, F. Lazreg, C. S. J. Cazin, Chem. Commun., 2014, 50, 8927-8929.

5) A simple access to transition metal cyclopropenylidene complexes. Y. D. Bidal, M. Lesieur, M. Melaimi, D. B. Cordes, A. M. Z. Slawin, G. Bertrand, C. S. J. Cazin, Chem. Commun, 2015, 51, 4778-4781.

6) A straightforward metal-free synthesis of 2-substituted thiazolines in air. M. Trose, F. Lazreg, M. Lesieur, C. S. J. Cazin, Green Chem., 2015, 17, 3090-3092.

7) Palladium (0) NHC Complexes: A New Avenue to Highly Efficient Phosphorescence. A. F. Henwood, M. Lesieur, A. K. Bansal, D. G. Thompson, D. Graham, A. M. Z. Slawin, I. D. W. Samuel, C. S. J. Cazin, E. Zysman-Colman, Chem. Sci., 2015, 6, 3248-3261.  These authors contributed equally to the work.

8) Versatile relay and cooperative NHC-Pd(0)/NHC-Cu(I) catalysis for the synthesis of tri- and tetra-substituted alkenes M. Lesieur, Y. D. Bidal, F. Lazreg, F. Nahra, C. S. J. Cazin, ChemCatChem, 2015, 14, 2108-2112.

9) Copper(I) abnormal and remote NHC complexes: Synthesis and catalytic activity in “Click Chemistry”. Y. D. Bidal, M. Lesieur, M. Melaimi, F. Nahra, D. B. Cordes, K. S. Athukorala Arachchige, , A. M. Z. Slawin, G. Bertrand, C. S. J. Cazin, Adv. Synth. Catal. 2015, 14-15, 3155. 

10) Silver N-heterocyclic carbene complexes: efficient catalysts for the alkynylation of ketones. F. Lazreg, M. Lesieur, A. J. Samson, C. S. J. Cazin, ChemCatChem, 2016, 8, 209.

11) Copper N-heterocyclic carbene complexes as active catalysts for the synthesis of 2-substituted oxazolines from nitriles and aminoalcohols. M. Trose, F. Lazreg, M. Lesieur, C. S. J. Cazin, J. Org. Chem. 2015, 20, 9910