Davir González-Calderón

dgonzalezIn 2012 Davir González obtained his Master degree in Organic Synthesis at the Universidad Autónoma del Estado de México (UAEM-Mexico) under the supervision of Prof. Carlos González-Romero working in the development of novel synthetic methodologies to carry out the cleavage of silyl ethers (see publications list below). At this stage (2010), he was appointed to a CONACyT fellowship to carry out a research project (Synthesis of L-Octaarginine through microencapsulated palladium-catalyzed allyl ester deprotection – see publications list below) at the University of Granada (Spain) under the supervision of Prof. Juan A. Tamayo-Torres and Prof. José Gómez-Vidal. In 2014, González started his PhD at the UAEM (under the supervision of Prof. Carlos González and Aydeé Fuentes) where his major efforts have been orientated towards the development of novel strategies to allow the obtaining of 1,2,3-triazole cores through azide-enolate (3+2) cycloadditions as well as its application in the synthesis of novel antifungal compounds (see publications list below). So far, he has published 14 articles (11 of these as first author).

In 2016, González was appointed to a CONACyT/SIEA-UAEM/COMECyT fellowship for a short stay (10/2016-03/2017) at the University of Cambridge to complete his doctoral thesis under the mentorship of Steve Ley on the discovery of new chemical reactivity of diazo intermediates and subsequent use as carbine precursor.

Current research: Discovery of new chemical reactivity of diazo intermediates and subsequent use as carbine precursor.


Antifungal activity of 1’-homo-N-1,2,3-triazol-bicyclic carbonucleosides: A novel type of compound afforded by azide-enolate (3+2) cycloaddition D. González-Calderón, M. G. Mejía-Dionicio, M. A. Morales-Reza, J. G. Aguirre-de Paz, A. Ramírez-Villalva, M. Morales-Rodríguez, A. Fuentes-Benítes, C. González-Romero.* Bioorg. Chem., 2016, 69, 1–6.

A straightforward and versatile protocol for the direct conversion of benzylic azides to ketones and aldehydes D. González-Calderón, M. A. Morales-Reza, E. Díaz-Torres, A. Fuentes-Benítes, C. González-Romero.* RSC Adv. 2016, 6, 83547-83550.

Azide–Enolate 1,3-Dipolar Cycloaddition as an Efficient Approach for the Synthesis of 1,5-Disubstituted 1,2,3-Triazoles from Alkyl/Aryl Azides and β-Ketophosphonates D. González-Calderón, A. Fuentes-Benítes, E. Díaz-Torres, C. A. González-González, C. González-Romero.* Eur. J. Org. Chem. 2016, 668–672.

Azide-enolate 1,3-dipolar cycloaddition in the synthesis of novel triazole-based miconazole analogues as promising anti fungal agents D. González-Calderón, A. Ramírez-Villalva, Carlos González-Romero, Aydeé Fuentes-Benítes.* Eur. J. Med. Chem. 2016, 112, 60-65.

A straightforward and versatile approach to the synthesis of 1,4,5-trisubstituted 1,2,3-triazoles from alkyl halides via a one-pot, three-component reaction D. González-Calderón, J. G. Aguirre-De Paz, C. A. Fuentes-Benítes, C. González-Romero.* Tetrahedron Lett. 2015, 56, 1713–1715.

A novel and facile synthesis of 1,4,5-trisubstituted 1,2,3-triazoles from benzylic alcohols through a one-pot, three-component system D. González-Calderón, I. Santillán-Iniesta, A. Fuentes-Benítes, C. González-Romero.* Tetrahedron Lett. 2015, 56, 514–516.

A facile synthesis of novel miconazole analogues and the evaluation of their anti fungal activity A. Ramírez-Villalva, D. González-Calderón, C. González-Romero, Aydeé Fuentes-Benítes.* Eur. J. Med. Chem. 2015, 97, 275-279.

Synthesis of caffeine from theobromine: Bringing back an old experiment in a new setting D. González-Calderón, C. A. González-González, A. Fuentes-Benítes, C. González-Romero.* Educ. Quím. 2015, 26, 9-12.

Aluminium Chloride Hexahydrate (AlCl3·6H2O): An Efficient, Facile, Mild, And Highly Chemoselective Catalytic Deprotection of Tert-Butyldimethylsilyl (TBS) Ethers D. González-Calderón, A. Fuentes-Benitez, C. González-Romero.* Synth. Commun. 2014, 44, 1258–1265.

Synthesis of l-Octaarginine through Microencapsulated Palladium-Catalyzed Allyl Ester Deprotection A. M. Pérez-López, D. González-Calderón, A. Occorso, J. Galindo-Ángel, J. F. Domínguez-Seglar, J. A. Tamayo, M. Díaz-Gavilán, J. A. Gómez-Vidal.* Synlett 2014, 25, 2319-2322.

A Novel Chemoselective Cleavage of (tert-Butyl)(dimethyl)silyl (TBS) Ethers Catalyzed by Ce(SO4)2·4H2O D. González-Calderón, C. A. Fuentes-Benitez, Carlos González-Romero.* Helv. Chim. Acta, 2014, 97, 965–972.

Cerium(IV) sulfate tetrahydrate: a catalytic and highly chemoselective deprotection of THP, MOM, and BOM ethers D. González-Calderón, Aydeé Fuentes-Benítez, Carlos González-Romero.* Tetrahedron Lett. 2013, 54, 7164–7166.

Selective deprotection of TBDMS alkyl ethers in the presence of TIPS or TBDPS phenyl ethers by catalytic CuSO45H2O in methanol D. González-Calderón, Aydeé Fuentes-Benítez, Carlos González-Romero.* Tetrahedron Lett. 2013, 54, 5130–5132.

Corey lactone as key precursor for a facile synthesis of novel 1,2,3-triazole carbocyclic nucleosides via Click Chemistry C. A. González-González, D. González-Calderón, A. Fuentes-Benítez, C. González-Romero.* Tetrahedron Lett. 2013, 54, 2726–2728.